Cefoperazone sodium and tazobactam sodium medicinal composition microsphere injection

Abstract

The invention discloses cefoperazone sodium and tazobactam sodium medicinal composition microsphere injection, which is characterized by comprising 4 to 8 weight parts of cefoperazone sodium, 1 to 2 weight parts of tazobactam sodium, 2.5 to 5 weight parts of PLA, 1.25 to 2.5 weight parts of Span60, 1 to 2 weight parts of glycerol monostearate and 1 to 2 weight parts of glucose. Compared with the prior art, the cefoperazone sodium and tazobactam sodium medicinal composition microsphere injection of the invention has the advantages of high stability, high entrapment rate, high-repeatability preparation process suitable for industrial production, uniform particle distribution, little solvent residue, high injectability and good sustained-release property.

Description

technical field The invention relates to a cefoperazone sodium tazobactam sodium pharmaceutical composition microsphere injection, which belongs to the technical field of medicine. Background technique Cefoperazone is a third-generation cephalosporin antibiotic that achieves bactericidal effect by inhibiting the biosynthesis of sensitive bacterial cell walls. Tazobactam has no antibacterial activity against other bacteria except Neisseriaceae and Acinetobacter, but tazobactam has activity against most important β-lactamases produced by β-lactam antibiotic-resistant strains Irreversible inhibition. Tazobactam can prevent drug-resistant bacteria from destroying penicillins and cephalosporins, and tazobactam has obvious synergistic effects with penicillins and cephalosporins. The compound preparation of cefoperazone sodium and tazobactam sodium has been sold in China at present, and all of them are directly packaged as aseptic powder. The common defect is that the preparatio...

AI Technical Summary

Problems solved by technology

The microsphere preparation of cefoperazone sodium sulbactam sodium is not disclosed in the prior art, and the pharmaceutical composition of excellent cefoperazone sodium sulbactam sodium is still needed in this field, which has excellent slow-release characteristics and stability. The present invention adopts microsphere technology to prepare Cefoperazone sodium and sulbactam sodium microspheres provide microsphere injections of cefoperazone sodium and sulbactam sodium with excellent sustained-release properties and stability

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