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Traditional Chinese Medicine Shikimic Acid Powder Injection

A technology for powder injection and shikimic acid, which is applied to the powder injection of traditional Chinese medicine shikimic acid and its preparation field, can solve the problems of reduced drug concentration, easy decomposition, difficulty in preparing injection preparations, etc., and achieves the effects of saving production costs and avoiding safety problems.

Active Publication Date: 2012-02-08
倪健
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Isopropylidene shikimic acid is mainly used for the treatment of thrombotic diseases. In the treatment of thrombotic diseases, non-vascular drug administration has processes such as absorption, which reduces the concentration of drugs entering the blood. In addition, isopropylidene shikimic acid does not Stable, so when preparing oral preparations, there is still the problem of easy decomposition in the stomach
Due to the unstable characteristics of isopropylidene shikimic acid, there are greater difficulties in the preparation of injection preparations

Method used

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  • Traditional Chinese Medicine Shikimic Acid Powder Injection
  • Traditional Chinese Medicine Shikimic Acid Powder Injection
  • Traditional Chinese Medicine Shikimic Acid Powder Injection

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0031] Experimental Example 1 3,4-O-isopropylidene shikimic acid solution stability test under different pH conditions

[0032] (1) Experimental method

[0033] 1. Principle: In the drug stability test, not only H + or OH - For specific acid-base catalysis, the composition of the buffer must also be considered, that is, the effect of general acid-base catalysis on the hydrolysis rate of the drug. The combination of these two catalytic types can reduce the apparent hydrolysis rate K obs Described as follows:

[0034] K obs = K o + K H + [ H + ] + K OH [ O H - ] - + K ...

experiment example 2

[0148] Experimental example 2 Determination experiment of drying temperature

[0149] Samples were prepared according to the prescription in Example 1, put into a freeze dryer for pre-freezing, and then the vacuum pump was turned on to enter the sublimation stage. After the ice crystals have completely disappeared, start to raise the temperature. Every 5°C is a measurement range, and the moldability of the solid is used as a macroscopic index to observe the highest temperature of the preparation during the heating stage. The results are shown in the table.

[0150] Determination of drying temperature

[0151]

[0152] From the experimental results, it can be known that the temperature higher than 35°C has an influence on the formability of the preparation.

experiment example 3

[0153] The selection of experimental example 3 freeze-dried proppants

[0154] Using the appearance and reconstitution of the freeze-dried product as an index, the addition of mannitol as a proppant was compared with that of no proppant, and the results are shown in the table below.

[0155] Proppant Screening Experiment

[0156]

[0157] Conclusion: From the above experiments, it can be seen that the freeze-dried preparation with uniform appearance can be obtained by adding mannitol as a proppant and directly freeze-drying without proppant, and the solution is clear after reconstitution.

[0158] The following embodiments can all achieve the effects of the above experimental examples.

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Abstract

The invention discloses a powder injection of traditional Chinese medicine shikimic acid, which is prepared by the following method: 10 parts by weight of 3,4-O-isopropylidene shikimic acid is dissolved in water for injection, and sodium hydroxide, sodium dihydrogen phosphate and phosphoric acid are added. Sodium hydrogen disodium, 110-140 ℃ pressure condition is 0.2-1.4kg / cm2 Sterilization 20-50 minutes, ultrafiltration after microporous membrane filtration, ultrafiltrate freeze-drying system; The present invention solves the problem of 3,4-O - The stability of isopropylidene shikimic acid prepared into powder injections saves production costs and avoids safety problems that may be caused by the use of skeleton materials.

Description

[0001] This application is a divisional application of an invention patent application with an application date of September 16, 2008, an application number of 200810212048.3, and an invention title of "isopropylidene shikimic acid powder injection". technical field [0002] The invention relates to a powder injection of traditional Chinese medicine, in particular to a powder injection of traditional Chinese medicine shikimic acid and a preparation method thereof. Background technique [0003] Shikimic acid (Shikmicacid, SA-1,) is a medicinal ingredient contained in the fruits of various plants of the genus Illicium in the Chinese herbal medicine Magnoliaceae, and its source is the fruit of Illicium henrvivar. The fruit is extracted by solvents such as methanol and refined. Its molecular formula is C 7 h 10 o 5 , with a molecular weight of 174.15. In recent years, the research on the mechanism of thrombosis and the development of antithrombotic drugs have attracted the a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K9/19A61K31/357A61P7/02A61P9/10
Inventor 倪健孙建宁郭亚建
Owner 倪健