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Chinese and Western medicine compound injection emulsion used for treating bacterial disease of poultry and livestock and preparation method thereof

A Chinese and Western medicine, bacterial technology, applied in the field of veterinary medicine, can solve the problems of easy generation of drug resistance, poor efficacy of bacterial diseases of livestock and poultry, etc., to achieve the effects of improving bioavailability, reducing the number of drugs, and reducing residues

Inactive Publication Date: 2011-01-19
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a Chinese and Western medicine compound injection emulsion for treating bacterial diseases of livestock and poultry to solve the problems of poor curative effect and easy drug resistance in the treatment of bacterial diseases of livestock and poultry.

Method used

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  • Chinese and Western medicine compound injection emulsion used for treating bacterial disease of poultry and livestock and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A. The formula of Chinese and Western medicine compound injection emulsion is:

[0025] 25 grams of enrofloxacin, 5 grams of baicalin, 300 ml of soybean oil, 0.1 grams of sodium sulfite, 2 grams of glycerin, 7 grams of emulsifier, of which 7 grams are Tween-80 and Span-80, and the rest is water for injection .

[0026] B, the method for preparing Chinese and western medicine compound injection emulsion is as follows:

[0027] 1) Measure 300ml of soybean oil, mix, filter, autoclave and let cool for later use, and take another 1000ml of water for injection, autoclave and let cool for later use;

[0028] 2) Weigh 25 grams of enrofloxacin and 5 grams of baicalin, 2 grams of glycerin, 0.1 grams of sodium sulfite, and then weigh 2 grams of Tween-80, and dissolve the above substances in a container containing 200ml of sterilized water, Heat to 60°C and stir evenly with a magnetic stirrer to obtain an aqueous phase;

[0029] 3) Take 5 grams of Span-80, dissolve it in 300m...

Embodiment 2

[0033] A. The formula of Chinese and Western medicine compound injection emulsion is:

[0034] 30 grams of enrofloxacin, 10 grams of baicalin, 350 ml of corn oil, 0.8 grams of sodium bisulfite, 18 grams of emulsifier, of which the emulsifier is lecithin and Span-80, a total of 18 grams, 4 grams of isotonic regulator, The isotonic regulator is a mixture of fructose and glucose, and the rest is water for injection.

[0035] B, the method for preparing Chinese and western medicine compound injection emulsion is as follows:

[0036] 1) Measure 350ml of corn oil, filter, autoclave and let cool for later use, and take another 1000ml of water for injection, autoclave and let cool for later use;

[0037] 2) Weigh 30 grams of enrofloxacin and 10 grams of baicalin, 4 grams of fructose and glucose, 0.8 grams of sodium bisulfite, and then weigh 8 grams of lecithin, and dissolve the above substances in 200ml of sterile In a container of water, heat to 80°C and stir evenly with a magnetic...

Embodiment 3

[0042] A. Chinese and Western medicine compound injection emulsion is prepared from the following ingredients:

[0043] 14 grams of enrofloxacin, 2 grams of baicalin, 150 ml of coconut oil, 0.4 grams of sodium thiosulfate, 3 grams of xylitol, 10 grams of emulsifiers, of which 10 grams are cholesterol and poloxamer, and the rest are Water for Injection.

[0044] B, the method for preparing Chinese and western medicine compound injection emulsion is as follows:

[0045] 1) Measure 150ml of coconut oil for injection, filter, autoclave and let cool for later use, and take another 1000ml of water for injection, autoclave and let cool for later use;

[0046] 2) Weigh 14 grams of enrofloxacin, 2 grams of baicalin, 3 grams of xylitol, 0.4 grams of sodium thiosulfate, and 2 grams of cholesterol, and dissolve the above substances in a container containing 200ml of sterilized water medium, heated to 70°C, and stirred evenly with a magnetic stirrer to obtain an aqueous phase;

[0047] ...

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Abstract

The invention discloses Chinese and Western medicine compound injection emulsion used for treating bacterial disease of poultry and livestock and a preparation method thereof. Each 1,000ml of injection consists of the following components: 1o to 30g of enrofloxacin, 1 to 10g of baicalin, 100 to 350ml of medical vegetable oil for injection, 5 to 20g of emulsifier, 0.1 to 1g of antioxygen, 2 to 6g of isoosmotic adjusting agent and the balance of water for injection. The preparation method comprises the following steps of: respectively weighing the vegetable oil for injection and the water for injection, sterilizing, and naturally cooling; weighing the enrofloxacin, the baicalin, the emulsifier, the isoosmotic adjusting agent and the antioxygen, dissolving in the sterilized water for injection, and heating and stirring to obtain a water phase; dissolving the emulsifier in the vegetable oil, and heating and stirring to obtain an oil phase; adding the water phase into the oil phase with stirring, emulsifying to obtain protogala, and further homogenizing; and fixing the volume to 1,000ml by using the sterilized water for injection, filling, and sterilizing to obtain the injection emulsion. The product has the advantages of sustained-release effect, high bioavailability, low administration frequency, a little medicament residue in vivo, and cost conservation.

Description

technical field [0001] The invention belongs to veterinary medicine, in particular to Chinese and Western medicine compound injection emulsion for treating bacterial diseases of livestock and poultry, and also relates to a preparation method of the injection emulsion. Background technique [0002] Livestock and poultry bacterial diseases are mainly caused by Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, Erysipelas, Proteus, Serratia marcescens, suppurative rod Bacillus, Botella septica, Pseudomonas aeruginosa, Streptococcus, Staphylococcus aureus, Mycoplasma, Chlamydia, etc. At present, the treatment of bacterial diseases of livestock and poultry mostly adopts a single antibacterial drug or pure Chinese medicine, and its therapeutic effect needs to be improved. In the clinical application of veterinary drugs, in order to give full play to the efficacy of drugs, repeated administration in a short period of time is required,...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/107A61P31/04A61K31/496
Inventor 吴红云李建正李凤娟
Owner ZHENGZHOU HOUYI PHARMA
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