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Medical antibacterial sponge dressing and preparation method thereof

A sponge and solution technology, which is applied in the field of antibacterial medical sponge and its preparation, can solve the problems of unsuitable wounds, insufficient water absorption, insufficient water absorption capacity, and insufficient antibacterial properties, and achieve the effects of soft texture, good water absorption capacity, and excellent antibacterial performance

Active Publication Date: 2013-08-14
SHENZHEN QIKANG MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the embodiments of the present invention is to provide an antibacterial medical sponge dressing to solve the problems of existing medical sponges such as insufficient water absorption, insufficient water absorption capacity, insufficient antibacterial properties, and unsuitable for susceptibility to infection or infected wounds.

Method used

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  • Medical antibacterial sponge dressing and preparation method thereof
  • Medical antibacterial sponge dressing and preparation method thereof
  • Medical antibacterial sponge dressing and preparation method thereof

Examples

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Effect test

example 1

[0064] Mechanical foaming combines a small amount of foaming agent method to prepare antibacterial medical PVA sponge dressing, comprising the steps:

[0065] (1) Mix 20g of PVA with 200g of deionized water, stir mechanically to gradually dissolve the PVA to prepare a mixed solution, then add 3ml of 1% silk fibroin solution, and add 0.01g of foaming agent per 100ml of the solution, After stirring evenly and slowly heating to 60°C, adjust the mechanical stirring speed to 800 rpm, and after stirring for 6 minutes, add 3 grams of OP to every 100ml of the mixture;

[0066] (2) After stirring for 5 minutes, add 37% formaldehyde solution, the amount added is 11ml formaldehyde solution per 100ml solution, continue stirring for 5 minutes, and then add sulfuric acid solution with a concentration of 50%, the amount of acid added is 100ml Add 12ml of acid solution to the solution;

[0067] (3) Start to reduce the stirring speed after stirring for 8 minutes, and reduce the stirring speed...

example 2

[0073] Mechanical foaming combines a small amount of foaming agent method to prepare antibacterial medical PVA sponge dressing, comprising the steps:

[0074] (1) Mix 25g of PVA with 220g of deionized water, stir mechanically to gradually dissolve the PVA to prepare a mixed solution, then add 2ml of 4% silk fibroin solution, and add 0.05g of foaming agent per 100ml of solution , stir evenly and slowly heat to 50°C, adjust the mechanical stirring speed to 1000 rpm, stir for 5 minutes, add 1 gram of OP to every 100ml of the mixture;

[0075] (2) After stirring for 4 minutes, add 37% formaldehyde solution, the addition amount is 10ml formaldehyde solution per 100ml solution, continue stirring for 4 minutes, then add 37% hydrochloric acid solution, the acid addition amount is 100ml solution Add 50ml acid solution;

[0076] (3) After stirring for 6 minutes, start to reduce the stirring speed, within 5 minutes, the stirring speed will drop to 200r / min, and stop stirring after 1 min...

example 3

[0082] Mechanical foaming combines a small amount of foaming agent method to prepare antibacterial medical PVA sponge dressing, comprising the steps:

[0083] (1) Mix 17g of PVA with 200g of deionized water, stir mechanically, gradually dissolve the PVA, and prepare a mixed solution, then add 1 ml of 5% silk fibroin solution, and add 0.1g of foaming agent per 100 ml of the solution, After stirring evenly and slowly heating to 70°C, adjust the mechanical stirring speed to 1400 rpm, and after stirring for 9 minutes, add 3 grams of OP to every 100ml of the mixture;

[0084] (2) After stirring for 15 minutes, add 37% formaldehyde solution, the amount added is 25ml formaldehyde solution for every 100ml solution, continue stirring for 8 minutes, then add 20% phosphoric acid solution, the amount of acid added is 100ml solution Add 20ml acid solution;

[0085] (3) After stirring for 10 minutes, start to reduce the stirring speed, within 5 minutes, the stirring speed will drop to 200r...

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Abstract

The invention relates to a medical antibacterial sponge dressing. Mainly based on the condensation polymerization of polyvinyl alcohol (PVA), nano silver, formaldehyde, acid, silk fibroin and a foaming agent in water solution, the medical antibacterial sponge dressing is prepared by the following steps of: preparing a specified amount of the PVA, the foaming agent and the silk fibroin, mixing with de-ionized water, mechanically stirring to prepare a mixed solution, uniformly stirring and heating gradually; stirring for a while and adding methanal water solution; stirring for a while again and adding an acid solution; carrying out aldolization of the PVA and the silk fibroin through under the action of the methanal in the acidic condition; adjusting the stirring speed till the end of the aldolization; curing and shaping the product; demolding and washingt; extruding and dewatering; and then socking into the nano silver solution for shaking for a period of time; and freeze drying and shaping. The prepared sponge has a uniform aperture of about 0.2-2mm, good water absorbing power and big water absorbing capacity, and has a water absorption rate of 1200% and an antibacterial rate of 99.9%.

Description

technical field [0001] The invention relates to a medical dressing, in particular to an antibacterial medical sponge and a preparation method thereof. Background technique [0002] Polyvinyl alcohol PVA foam sponge has excellent water absorption, soft texture after absorbing water and good heat resistance and wear resistance, so it can be used in filter materials, sound insulation and heat insulation materials, wiping cloths, medical and sanitary materials, etc. . When PVA sponge is used as a medical material, especially when in contact with susceptible or infected wounds, it is not only required to have good water absorption, but the material should also have antibacterial properties. There have been some reports on antibacterial materials, such as Chinese Invention Patent Publication No. CN101187089A, using silk fibroin, silver elemental ions and PVA for electrospinning to prepare a blended fiber mat, which is mainly used for tissue engineering scaffolds . Chinese Paten...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/24A61L15/18A61L15/44A61L15/60C08L29/04C08L89/00C08K13/02C08K3/08C08K5/07C08J9/08C08J3/24
Inventor 佘振定谭荣伟王明波
Owner SHENZHEN QIKANG MEDICAL DEVICES