Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Methylprednisolone aceponate cream preparation

A technology of methylprednisolone acetate and cream, applied in the field of medicine, can solve the problems that are not conducive to drug absorption, and the effect of emulsifiers is not fully considered.

Inactive Publication Date: 2013-05-22
PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent (application number 200710060219.0) discloses a kind of methylprednisolone acetate emulsifiable paste, this patent does not fully consider the effect of emulsifying agent, and insoluble methylprednisolone acetate is prepared into suspension by solubilizer, dissolves in In the matrix of water phase and oil phase, methylprednisolone acetone does not become a molecular state in the matrix, which is not conducive to the absorption of drugs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Methylprednisolone aceponate cream preparation
  • Methylprednisolone aceponate cream preparation
  • Methylprednisolone aceponate cream preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] A kind of methylprednisolone acetate emulsifiable paste, it is made up of emulsifiable paste by methylprednisolone acetate, oil phase base, oil phase emulsifier, water phase base and water phase emulsifier, wherein oil phase emulsifier HLB value 1.0, oil phase The phase emulsifier accounts for 2% of the cream weight, the water phase emulsifier HLB value is 15, and the water phase emulsifier accounts for 3% of the cream weight.

Embodiment 2

[0084] A kind of methylprednisolone acetate cream, it is made up of methylprednisolone acetate, oil phase base, oil phase emulsifier, water phase base and water phase emulsifier to form emulsifiable paste, wherein oil phase emulsifier HLB value 4.0, oil phase Phase emulsifier accounts for 8% of cream weight, and water phase emulsifier HLB value is 18, and water phase emulsifier accounts for 9% of cream weight.

Embodiment 3

[0086] A kind of methylprednisolone acetate cream, it is made up of methylprednisolone acetate, oil phase base, oil phase emulsifier, water phase base and water phase emulsifier to form emulsifiable paste, wherein oil phase emulsifier HLB value 2.7, oil phase The phase emulsifier accounts for 4.5% of the weight of the cream, the HLB value of the water phase emulsifier is 15.3, and the water phase emulsifier accounts for 5.0% of the weight of the cream.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a methylprednisolone aceponate cream preparation, which is characterized by consisting of methylprednisolone aceponate, oil phase matrix, oil phase emulsifier, aqueous phase matrix and aqueous phase emulsifier, wherein the HLB (hydrophile-lipophile balance) value of the oil phase emulsifier is 1.0 to 4.0, the oil phase emulsifier accounts for 2 to 8 percent of the weight of the cream, the HLB value of the aqueous phase emulsifier is 15 to 18, and the aqueous phase emulsifier accounts for 3 to 9 percent of the weight of the cream. The cream preparation has good stability and release degree.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a methylprednisolone acetate cream preparation. Background technique [0002] Methylprednisolone acetate, chemical name: 21-acetoxy-11β-hydroxy-6α-methyl-17-propionyloxy-1,4-pregnadiene-3,20-dione, clinically used Treatment Treats eczema and psoriasis in adults and children. [0003] Eczema is a common inflammatory allergic skin disease, and the main symptom of eczema is severe itching. The damage of acute eczema is erythema, papule, vesicle, exudate etc., conscious burning hot and pruritus. After a long period of time or after treatment, the acute inflammation is relieved, and the skin lesions are dry and scabbed, entering the subacute stage. Chronic eczema can be caused by repeated attacks in the acute and subacute stages, or it can be chronic at the beginning, and the damage is mainly manifested as skin thickening, rough surface, and pigmentation. It is especially common ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/573A61P17/00A61P17/06
Inventor 顾群金治刚孙学伟徐春霞孙德杰
Owner PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com