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Annonaceous acetogenin extract, preparation method thereof and use thereof in cancer resistance and relief of cancerous pain

A technology of extract and lychee, which is applied in the medical field, can solve problems such as difficulty in achieving large-scale production, unfavorable preparation requirements, and loss of active ingredients, and achieve the effects of low cost, shortened production cycle, and human health and safety

Inactive Publication Date: 2011-02-23
广西正鑫生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The components of total lactones and extracts are too complex, and the quality of the drug is difficult to control, which is not conducive to the preparation requirements; only a single component is selected for burataxin and anemone, which not only causes the loss of another high active component, but also does not Facilitate separation and purification, resulting in very high production costs, making it difficult to achieve large-scale production
In addition, almost all patented studies focus solely on extracting the active ingredient from the seeds

Method used

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  • Annonaceous acetogenin extract, preparation method thereof and use thereof in cancer resistance and relief of cancerous pain
  • Annonaceous acetogenin extract, preparation method thereof and use thereof in cancer resistance and relief of cancerous pain
  • Annonaceous acetogenin extract, preparation method thereof and use thereof in cancer resistance and relief of cancerous pain

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Embodiment 1: get through cleaning and drying custard apple seed, leaf, bark, according to cinnamon apple seed: leaf: the weight ratio of bark is the ratio preparation raw material of 6: 2: 2, totally 8.0kg, will mix after The raw materials are crushed and passed through a 40-mesh sieve, and 12 kg of 95% alcohol is added according to the weight ratio of the raw materials and alcohol at a ratio of 2:3, soaked and extracted for 48 hours, soaked and extracted repeatedly for 3 times, concentrated under reduced pressure to recover the alcohol, and the concentrated solution is combined to obtain the alcohol extract Add sherwood oil and 1000ml of water to the alcohol extract and shake fully, discard the water layer after standing for stratification to get the sherwood oil extract; add 80% alcohol to the extract for back extraction, repeat back extraction 5 times, each time Add 1000ml of 80% alcohol, after static layering, collect 5700ml of alcohol layer stripping solution, conc...

Embodiment 2

[0024]Embodiment 2: get through washing and drying the custard apple seed, leaf, bark according to the cinnamon apple seed: the weight ratio of leaf: bark is the ratio preparation raw material of 6: 2: 2, totally 8.0kg, pulverize and pass through 60 orders Sieve, add 12kg of 95% alcohol according to the ratio of raw material to alcohol weight ratio of 2:3, soak and extract for 56 hours, repeat soaking and extraction for 3 times, concentrate under reduced pressure to recover alcohol and combine the concentrated solution to obtain alcohol extract; add 1000ml of petroleum ether and 1000ml of water were fully shaken, and the water layer was discarded after standing for stratification to obtain petroleum ether extract; 80% alcohol was added to the extract for back extraction, and the back extraction was repeated 5 times, adding 1000ml of 80% alcohol each time, After standing for stratification, collect 6000ml of the alcohol layer stripping solution in total, concentrate under reduce...

Embodiment 3

[0025] Embodiment 3: get through cleaning and drying custard apple seed, leaf, bark, according to cinnamon apple seed: leaf: the weight ratio of bark is the ratio preparation raw material of 6: 2: 2, altogether 8.0kg, pulverizes and 80 order Sieve, add 12kg of 90% alcohol according to the ratio of raw material to alcohol weight ratio of 2:3, soak and extract for 72 hours, repeat soaking and extracting for 3 times, concentrate under reduced pressure to recover alcohol and combine the concentrated solution to obtain alcohol extract; Add 1000ml of petroleum ether and 1000ml of water, shake fully, and discard the water layer after standing for stratification to obtain petroleum ether extract; add 80% alcohol to the extract for back extraction, repeat the back extraction 5 times, add 1000ml of 80% alcohol each time , after standing for stratification, the alcohol layer stripping solution was collected to be 5800ml in total, concentrated under reduced pressure and removed 80% alcohol...

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Abstract

The invention provides an annonaceous acetogenin extract extracted from seeds, leaves and barks of Annona squamosa L., a preparation method thereof, an external preparation taking the annonaceous acetogenin extract as an active ingredient, and medicinal use of the external preparation in cancer resistance and relief of cancerous pain. The preparation method for the annonaceous acetogenin extract has a simple process, common, low-price and low-toxicity reagents are adopted and are environment-friendly and relatively safe for human health, the production cost is lower, and the whole preparation method is easy to implement, can effectively shorten the production cycle and is suitable for mass production. An external patch comprising the annonaceous acetogenin extract serving as the active ingredient is easy to use, and has prominent curative effect on cancerous pain and no side effect.

Description

technical field [0001] The invention belongs to the medical field, and in particular relates to an anemone lactone extract, a preparation method thereof and an application in anticancer and alleviating cancer pain. Background technique [0002] Annonaceae is a plant group that grows in tropical and subtropical regions. It is native to tropical America and is now cultivated in tropical regions all over the world. In my country, it is mainly cultivated in Hainan, Guangdong, Taiwan, Fujian, Guangxi, Yunnan and other places, and especially Shantou and Dongguan in Guangdong have the best quality. The leaves, fruit seeds, stem bark and bark of this family of plants contain a variety of biologically active components, such as alkaloids, terpenes, flavonoids, annona lactones, etc. Among them, the most widely studied is annonaceous acetogenins, a new type of natural product first discovered by American scientists from Annonaceae plants in 1982. Anemone lactone has a wide range of p...

Claims

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Application Information

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IPC IPC(8): A61P35/00A61K31/473A61K31/7048A61P29/00A61K36/185A61K31/365
Inventor 杨正强周显勇王琪袁胜伟
Owner 广西正鑫生物科技有限公司
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