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Preparation method of calcium phosphate nano medicament-carrying systems

A nano-loaded drug and calcium phosphate technology, which is applied in prosthesis, medical science, inorganic non-active ingredients, etc., can solve the problems of using organic reagents, obvious burst release phenomenon, deposition on the surface or in large holes, etc., to achieve non-toxic Harmful additives, simple process, large drug loading effect

Active Publication Date: 2011-02-23
江苏先进无机材料研究院
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AI Technical Summary

Problems solved by technology

[0004] However, the research of calcium phosphate micro-nano material drug carriers also faces problems such as low drug loading, serious burst release phenomenon, and the use of organic reagents in the synthesis process and drug loading process.
In the past, the loading strategy of calcium phosphate carriers for insoluble drugs is basically: the calcium phosphate carrier material is placed in the organic solvent solution of the drug for solvent evaporation, but most of the drugs are deposited on the surface or in large pores in this method, which is not effective with The sudden release phenomenon is obvious due to the combination of the carrier; or the drug is loaded through the adsorption of the calcium phosphate carrier material in the organic solvent, but there are disadvantages such as cumbersome synthesis process and the use of organic additives

Method used

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  • Preparation method of calcium phosphate nano medicament-carrying systems
  • Preparation method of calcium phosphate nano medicament-carrying systems
  • Preparation method of calcium phosphate nano medicament-carrying systems

Examples

Experimental program
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Effect test

Embodiment 1

[0039] 2.063g ibuprofen and 0.368g CaCl 2 2H 2 O was dissolved in 65 mL of absolute ethanol, and 7 mL of 1 mol / L NaOH aqueous solution and 3 mL of deionized water were added dropwise under magnetic stirring to form solution A. 0.537g Na 2 HPO 4 12H 2 O was dissolved in 25 mL of deionized water to form solution B. The solution B was poured into the solution A under magnetic stirring, and reacted for 1 minute. At this time, the pH value of the mixed solution was measured to be 6.6. The reaction product was collected by centrifugation, washed with water, dried under vacuum at 60°C and then ground. The product of this embodiment is measured by thermogravimetric analysis to have a drug loading of ibuprofen of about 0.47 gram of ibuprofen / gram of calcium phosphate. The drug release curve of the drug-loaded calcium phosphate in simulated body fluid obtained through detection is as follows: figure 1 As shown, it can be seen from the figure that the release behavior research in ...

Embodiment 2

[0042] 2.063g ibuprofen and 0.368g CaCl 2 2H 2 O was dissolved in 65 mL of absolute ethanol, and 10 mL of deionized water was added dropwise under magnetic stirring to form solution A. 0.537g Na 2 HPO 4 12H 2O was dissolved in 25 mL of deionized water to form solution B. The solution B was poured into the solution A under magnetic stirring, and reacted for 1 minute. At this time, the pH value of the mixed solution was measured to be 3.6. The reaction product was collected by centrifugation, washed with water, dried under vacuum at 60°C and then ground. The product of this example has a drug loading capacity of ibuprofen of about 0.35 grams of ibuprofen / gram of calcium phosphate measured by thermogravimetric analysis, and the release behavior in simulated body fluids shows that the product of this example has a good drug sustained release effect.

Embodiment 3

[0044] 2.063g ibuprofen and 0.368g CaCl 2 2H 2 O was dissolved in 65 mL of absolute ethanol, and 3 mL of 1 mol / L NaOH aqueous solution and 7 mL of deionized water were added dropwise under magnetic stirring to form solution A. 0.537g Na 2 HPO 4 12H 2 O was dissolved in 25 mL of deionized water to form solution B. The solution B was poured into the solution A under magnetic stirring, and reacted for 1 minute. At this time, the pH value of the mixed solution was measured to be 5.6. The reaction product was collected by centrifugation, washed with water, dried under vacuum at 60°C and then ground. The product of this example has a drug loading capacity of ibuprofen of about 0.68 grams of ibuprofen / gram of calcium phosphate as measured by thermogravimetric analysis, and the release behavior in simulated body fluids shows that the product of this example has a good drug sustained release effect.

[0045] The drug-loaded calcium phosphate obtained in Example 3 is subjected to ...

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Abstract

The invention relates to a preparation method of calcium phosphate nano medicament-carrying systems and belongs to the field of biomaterial material preparation and medicament sustained release. By the method, a calcium phosphate nano carrier is prepared in a mixed solvent and is synchronously loaded with water-insoluble medicaments. The method comprises the following steps of: dissolving soluble calcium salt and the water-insoluble medicaments into an organic solvent; adding aqueous solution of soluble phosphate; and synthesizing the calcium phosphate nano carrier, and synchronously carrying the medicaments at the same time. The carrying capacity of the medicaments can be regulated by changing pH value and the concentration of reactants. The prepared series of calcium phosphate nano medicament-carrying systems have different medicament carrying capacities and medicament sustained-release effects. The invention has the advantages that: the preparation method has a simple and fast process and low cost, is environmental friendly and easy to industrialize, and the like.

Description

technical field [0001] The invention relates to a preparation method of a calcium phosphate nano drug loading system, which is to prepare a calcium phosphate nano carrier in a mixed solvent and simultaneously load insoluble drugs in water, and belongs to the field of biological material preparation and drug sustained release. Background technique [0002] A large number of clinical drugs such as ibuprofen, atorvastatin calcium, and indomethacin are insoluble in water. How to improve the curative effect of these drugs is a key scientific problem that needs to be solved. The application of drug carriers, especially nanocarriers, can enable such drugs to achieve long-term stable release in the human body, thereby greatly improving drug efficacy. [0003] Calcium phosphate micro-nano materials, block polymers, liposomes, mesoporous materials, carbon nanotubes and fullerenes, and many composite materials are used in drug delivery systems. Different materials have different applic...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61K47/02
Inventor 朱英杰汤启立
Owner 江苏先进无机材料研究院
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