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Thickening and stable animal iron-supplement composition

A composition and stable technology, applied in the directions of drug combinations, plant raw materials, medical preparations containing active ingredients, etc., can solve the problems of decreased carcass quality, troublesome methods, low absorption rate, etc., and achieve appropriate and easily acceptable routes of administration. , good stability

Inactive Publication Date: 2011-03-23
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method of adding iron supplementation preparations in water has the disadvantages of adhesion in the reservoir, high cost, and unsatisfactory effect; the iron supplementation method of feeding bottles and breast milk smearing method have the problems of cumbersome methods and low absorption rate; Red soil is easily polluted by piglet feces and urine, which increases the chance of piglets being infected with parasites, and the relative biological potency of iron oxide in red soil is only 12% of ferrous sulfate, and the absorption rate is lower; the method of adding iron preparations to feed exists The feed intake of piglets is very small, and some even do not feed. The effect of iron supplementation for piglets a few days after birth is very unsatisfactory; Contaminated needles with pathogens and reduced carcass quality due to spotting at the injection site

Method used

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  • Thickening and stable animal iron-supplement composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1. Preparation of a thickened and stable animal iron supplement composition

[0019] Unless otherwise specified, the sample contains 10% iron methionine, 2% hypromellose, 1% aspartame, 5% atractylodes extract, 5% angelica extract, 0.5% water lemon essence, and the solvent is purified water.

[0020] The preparation method of the composition is as follows: mix hypromellose with purified water, stir thoroughly, after the liquid is stable, slowly add iron methionine while stirring; also add 1% aspartame, 5% under stirring Atractylodes Rhizome extract, 5% angelica extract and 0.5% water lemon essence are then used to make the volume with purified water, and the thickened organic iron composition is obtained after thorough stirring.

Embodiment 2

[0021] Example 2. Stability investigation and evaluation method and stability investigation result of thickening organic iron composition

[0022] Unless otherwise specified, the following steps are used for stability evaluation. The sample in Example 1 is placed in a constant temperature and humidity box with a temperature of 60°C±2°C and a humidity of 75%±5%. During the stability investigation, the appearance properties and viscosity of the composition were measured, and in some cases the free iron content in the composition was measured, and compared with the initially formulated composition. Use the SYD-04 type automatic kinematic viscosity tester (produced by Jilin Dongfang Weian Technology (Instrument) Co., Ltd.) to determine the viscosity of the composition. The viscosity unit is cP. The free iron content is measured by a combination of titration and spectrophotometry. .

[0023] After the composition in Example 1 was placed under the above conditions for 6 months, there w...

Embodiment 3

[0024] Example 3. Determination of clinical iron supplement effect and cost accounting of thickening organic iron

[0025] Carry out the following clinical experiments on the samples in the above example 1

[0026] 1Materials and methods

[0027] 1.1 Test materials

[0028] The control drug is iron methionine (Fe 2 Met) purchased from a domestic company, the iron content is 15%, and the test drug is the sample obtained in Example 1.

[0029] 1.2 Feeding and management of experimental pigs and experimental animals

[0030] The test animals were 34 two-day-old, three-way hybrid piglets, randomly divided into two groups, each with 17 piglets, all provided by a pig farm in Dongli Development Zone. The test period was 1 month. The first group is the test group, the composition in Example 1 is supplemented with iron at 100 mg / head in the oral backlog; the second group is the control group, with iron methionine taken orally, with iron supplement at 100 mg / head. The feeding management and star...

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Abstract

The invention provides a thickening and stable animal iron-supplement composition which contains the following components: 0.01% to 30% weight ratio of organic irons, 0.01% to 15% weight ratio of thickeners, 0.05% to 5% weight ratio of sweeteners, 0.1% to 20% of refined Chinese traditional medicine extractives and 0.01% to 5% weight radio of aromatics. With the composition, not only the problem that an oral iron-supplement medicine has the disadvantages of odour small, lower absorption rate, inaccurate quantitation, and the like can be effectively solved, but also the problem of how to repair atrophy gastric mucosa caused by iron deficiency can be solved through a complex traditional medicine extractive.

Description

Technical field [0001] The present invention belongs to the technical field of veterinary medicine, and particularly relates to a stabilized thickening iron supplement composition. The composition not only solves the problems of oral iron supplementation such as peculiar smell, low absorption rate, and inaccurate quantification, etc. The compound extract of traditional Chinese medicine solves the problem of repairing atrophic gastric mucosa caused by iron deficiency. In clinical use, it has the advantages of convenient administration, high drug utilization, long residence time in the body, and no stress to animals. Background technique [0002] Although iron is low in animals, its physiological and biochemical functions are very important. It is a component of many enzymes such as hemoglobin, myoglobin, cytochrome C, cytochrome oxidase, catalase, and peroxidase. Iron deficiency can cause iron deficiency anemia, especially in piglets. Iron-deficiency anemia in piglets is also c...

Claims

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Application Information

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IPC IPC(8): A61K36/284A61K36/232A61K36/752A61K38/02A61P3/02A61K31/191A61K31/194A61K31/198
Inventor 刘桂兰
Owner TIANJIN RINGPU BIO TECH
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