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Powdery mixture containing phytosterol and oryzanol and preparation method thereof

A technology of phytosterols and mixtures, which is applied in the direction of medical preparations containing active ingredients, food preparation, drug combinations, etc., can solve the problem of limited solubility or dispersibility, cannot significantly improve bioavailability, and poor solubility of phytosterol powder To achieve the effect of improving bioavailability, lowering the level of total cholesterol in the human body, and lowering the level of total serum cholesterol

Inactive Publication Date: 2011-03-30
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Early clinical trials of phytosterols confirmed that untreated phytosterol powders have poor solubility and low bioavailability. Simply mixing phytosterols with emulsifiers has limited effect on improving the solubility or dispersibility of phytosterols, and cannot significantly improve Bioavailability, the effect of lowering blood lipids is not ideal

Method used

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  • Powdery mixture containing phytosterol and oryzanol and preparation method thereof
  • Powdery mixture containing phytosterol and oryzanol and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] In a 200 mL container, 10 g of sitosterol, 10 g of oryzanol, and 5 g of polyglyceryl stearate (HLB12) were mixed, and then the mixture was melted at 140° C. under stirring. After complete melting, the mixture was stored at -10°C for rapid cooling. After the obtained solid was preliminarily crushed, it was further crushed with a ball mill (the grinding medium was zirconia beads). After grinding, the grinding medium was sieved to remove the grinding medium. After pulverization, the sample was sampled for measurement. The diameter of the powder was less than 100 μm. The data are shown in Table 1.

[0023] Table 1

[0024] Particle size (μm)

[0025] 18.86

Embodiment 2

[0027] In a 200 mL container, 10 g of campesterol, 10 g of oryzanol, and 5 g of sucrose stearate (HLB13) were mixed, and then the mixture was melted at 140° C. under stirring. After complete melting, the mixture was stored at -10°C for rapid cooling. After the obtained solid was preliminarily pulverized, it was further pulverized with a ball mill (the grinding medium was zirconia beads), and after grinding, it was sieved to remove the grinding medium. After pulverization, the sample was sampled and measured. The diameter of the powder was less than 100 μm, and the data was similar to that of Example 1.

Embodiment 3

[0029] In a 200 mL container, 15 g of sitosterol, 5 g of oryzanol, 2.5 g of polyglyceryl stearate (HLB12) and 2.5 g of sucrose stearate (HLB 13) were mixed, and then the mixture was melted at 140° C. under stirring. After complete melting, the mixture was stored at -10°C for rapid cooling. The obtained solid was preliminarily pulverized and then pulverized by a jet mill. The diameter of the pulverized sample powder was less than 20 μm. The data are shown in Table 2.

[0030] Table 2

[0031] Particle size (μm)

[0032] 3.519

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Abstract

The invention provides a powdery mixture containing phytosterol and oryzanol and a preparation method thereof. The powdery mixture contains the phytosterol, the oryzanol and at least one emulsifier. The granular diameter of the powdery mixture ranges from 0.04 micrometer to 100 micrometers. The powdery mixture maximizes the lipid-reducing effects of the phytosterol and the oryzanol by utilizing the synergistic effect of the phytosterol and the oryzanol. According to the preparation method, the dimension of the powdery mixture is controlled by first congruent melting and then cooling solidification, the obtained granular diameter ranges from 0.04 micrometer to 100 micrometers, and the bioavailability of the powdery mixture is greatly improved; and the powdery mixture can reduce the serum total cholesterol, the low density lipoprotein cholesterol and the triglyceride after being eaten and also be used for various foods taking no matter any food as bases and has outstanding dispersion stabilization.

Description

technical field [0001] The invention relates to a powdery mixture and a preparation method thereof, in particular to a powdery mixture containing phytosterol and oryzanol and a preparation method thereof. Background technique [0002] Phytosterol is the general term for various sterols in plants. There are currently more than 40 known species, of which the main component is sitosterol, which is about 50%; followed by campesterol, which is about 33%; seed sterol, etc. Phytosterols are steroidal compounds with a hydroxyl group at the 3-position. According to their chemical structures, they can be divided into three categories: 4-non-methyl sterols, 4-monomethyl sterols and 4,4’-dimethyl sterols. Phytosterols are usually flaky or powdery white solids with relatively high melting points, such as stigmasterol with a melting point of 167-170°C. The relative density of sterol is slightly higher than water, insoluble in water, soluble in ether, benzene, chloroform, petroleum ether...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/30A61K31/575A61P3/06A61P9/00A23L33/11A23L33/15
Inventor 郝国防任广智
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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