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Pharmaceutical composition of antibiotics and prebiotics for preventing and treating dysbiosis during antibacterial therapy

A technology of dysbiosis and composition, applied in the field of medicine, can solve problems such as losing clinical significance, and achieve the effect of improving blood components

Inactive Publication Date: 2011-03-30
亚历山大·弗拉基米罗维奇·季科夫斯基
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these antibiotics (tetracyclines and penicillins) have been identified for more than fifty years and have largely lost their clinical significance, consistent with widespread bacterial resistance to penicillins (which produce β-lactamase) and resistance to tetracyclines (R plasmid with Tc gene), but they are causing more and more allergic reactions

Method used

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no. 2 approach

[0023] According to a second embodiment, the essence of the invention, with regard to the oral application of the pharmaceutical composition, is that it contains a sulfonamide preparation and lactulose, the sulfonamide preparation having a particle size from 40 to 150 μm, the lactulose having a particle size of up to 0.3 mm and a purity of at least 97 %, the weight ratio of sulfonamide preparation and lactulose is 1:12.

[0024] Preferably, it includes sulfadimezine (sulfadimezine) / sulfadiazine (sulfazine) as a sulfonamide preparation and additionally includes a pharmaceutically acceptable amount of adjuvants selected from fillers, flavoring agents, flavoring agents and fragrances, and is prepared as a suitable Oral dosage forms selected from capsules, tablets, powders, pills, sugar-coated pills, granules, sachets, gels, pastes, syrups, emulsions, suspensions and solutions; pharmaceutical compositions orally 2-3 times.

no. 1 approach

[0025] According to a first embodiment, the pharmaceutical composition is prepared by mixing antibiotics and lactulose in powder form, said pharmaceutical composition comprising antibiotics and lactulose, antibiotics having a particle size of from 20 to 160 μm, and lactulose having a particle size of up to 0.3mm and a purity of at least 97%, the ratio of antibiotics and lactulose from 1:0.1 to 1:100; in addition antibiotics are in powder form, particle size from 20 to 160 μm, lactulose powder up to 0.3mm and a purity of at least 97%, antibiotics and The weight ratio of lactulose is from 1:0.1 to 1:100. Preferably, the method further includes mixing auxiliary materials selected from fillers, flavoring agents, flavoring agents and aromatic substances.

[0026] According to the first embodiment, the preparation method of the pharmaceutical composition is realized by mixing the sulfonamide preparation and lactulose in powder form, the pharmaceutical composition comprises the sulfo...

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Abstract

The invention relates to medicine and pharmacology, in particular to pharmaceutical compositions containing the following antimicrobial preparations: antibiotics and sulphanylamides combined with prebiotic in the form of a lactulose. The composition is used for preventing enteral dysbiosis arising during antibiotic therapy using the wide range of preparations. The inventive pharmaceutical composition contains antibiotic or a sulphanylamide preparation and lactulose, wherein the antibiotic particle size ranges from 20 to 160 mkm, the sulphanylamide preparation particle size ranges from 40 to 150 mkm and the lactulose has a particle size equal to or less than 0.3 mm and the purity of at least 97%, with the ratio of the antibiotic and lactulose ranging from 1:0.1 to 1:100, and the ratio of the sulphanylamide preparation and lactulose of 1:12, said composition being internally administered. The inventive preparations contribute to the preservation of antibiotic-damaged intestinal flora by producing selective prebiotic action on the growth of dominant types of microflora of the large intestine, such as lactobacilli and bifidobacteria.

Description

technical field [0001] This group of inventions relates to medicine, that is, pharmacy and the research progress of pharmaceutical preparation compositions containing antibiotics and prebiotics, which are used to improve the composition of intestinal microecology in antibiotic treatment. Background technique [0002] The use of broad-spectrum antibiotics to treat infections and other diseases is often associated with gastrointestinal side effects, which are mainly related to the negative effects of antibiotic preparations on the intestinal tract and other lumens. When taken orally, antibiotics eliminate not only pathogens, but also the resident microorganisms of the digestive tract, leading to a disturbance of homeostasis and contributing to the development of dysbiosis and allergic reactions. Imbalances in the gut microflora lead in many cases to a disordered state of the immune system, as well as to the active proliferation of unicellular fungi that colonize the mucosa of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7016A61K45/06A61K9/20A61P1/00A61K9/14A61K9/10A61K9/08
CPCA61K9/145A61K9/14A61K31/7016A61K47/26A61K45/06A61P1/00A61P31/00A61K2300/00
Inventor 奥列格·瓦连京诺维奇·多罗日科鲍里施·阿纳托利耶维奇·鲁多伊亚历山大·弗拉基米罗维奇·季科夫斯基
Owner 亚历山大·弗拉基米罗维奇·季科夫斯基
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