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Luodwei dorjie granules and preparation method thereof

A technology for granules and preparations, applied in the field of Luodui Duoji granules and their preparation, can solve the problems of poor stability, affecting the clarity and appearance of preparations, and achieve the effects of convenient taking, small size and fast absorption

Inactive Publication Date: 2011-04-06
TIBET UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the pre-test, it was found that after the original prescription was extracted, after high-speed centrifugation and alcohol precipitation, it was placed for a certain period of time, and there were precipitates, which affected the clarity and appearance of the preparation.
In addition, the product made into oral liquid has a bitter taste and poor stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1) Take medicine: get 30 parts of Alpine Codonopsis pilosula, 30 parts of broad tendon rattan, 20 parts of woody fragrance, 18 parts of Saibei Corydalis and 20 parts of Gansong by mass parts;

[0018] 2) Add the medicinal material taken in step 1) into 60% ethanol solution with a concentration of 10 times its mass, reflux extraction twice, each reflux time is 1 hour, filter, combine ethanol liquid, reclaim ethanol, concentrate into Clear paste with a density of about 1.25g / ml;

[0019] 3) Dry the clear paste obtained in step 2) at 60°C under reduced pressure, crush it and pass it through a 100-mesh sieve to obtain a fine powder;

[0020] 4) Mix 30% fine powder with 70% auxiliary materials according to the mass percentage, make it into a soft material with 50% ethanol, pass it through a 14-mesh sieve, and dry the prepared granules at 50-80°C , whole grains, packaged, ready to be obtained;

[0021] The auxiliary materials are composed of 20 parts of dextrin, 40 parts of...

Embodiment 2

[0023] 1) Take medicine: get 25 parts of Alpine Codonopsis pilosula, 27 parts of broad tendon rattan, 15 parts of woody fragrance, 15 parts of Saibei Viola and 15 parts of Nardson by mass parts;

[0024] 2) Add the medicinal materials taken in step 1) into 55% ethanol solution with a concentration of 8 times its mass, reflux extraction twice, each reflux time is 0.5 hour, filter, combine ethanol liquid, reclaim ethanol, concentrate into Clear paste with a density of about 1.35g / ml;

[0025] 3) The clear paste obtained in step 2) is dried under reduced pressure at 80° C., crushed and sieved into a 100-mesh sieve to obtain a fine powder;

[0026] 4) Mix 25% fine powder with 75% auxiliary materials according to the mass percentage, make it into a soft material with 60% ethanol, pass it through a 14-mesh sieve to make granules, and dry the granules at 50-80°C , whole grains, packaged, ready to be obtained;

[0027] The auxiliary materials are composed of 15 parts of dextrin, 35 ...

Embodiment 3

[0029] 1) Take medicine: get 35 parts of Alpine Codonopsis pilosula, 27 parts of broad tendon rattan, 25 parts of Muxiang, 23 parts of Saibei Corydalis and 25 parts of Nardinus by mass parts;

[0030] 2) Add the medicinal materials taken in step 1) into 65% ethanol solution with a concentration of 12 times its mass, reflux and extract twice, each reflux time is 1 hour, filter, combine the ethanol liquid, reclaim the ethanol, and concentrate it into Clear paste with a density of about 1.3g / ml;

[0031] 3) The clear paste obtained in step 2) is dried under reduced pressure at 50° C., crushed and sieved into a 100-mesh sieve to obtain a fine powder;

[0032] 4) Mix 35% fine powder with 65% auxiliary materials according to the mass percentage, make it into a soft material with 40% ethanol, pass it through a 14-mesh sieve, and dry the prepared granules at 50-80°C , whole grains, packaged, ready to be obtained;

[0033] The auxiliary materials are composed of 25 parts of dextrin, ...

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PUM

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Abstract

The invention discloses luodwei dorjie granules and a preparation method thereof. The method comprises the following steps of: refluxing codonopsis alpine, tinospora sinensis, costustoot, corydalis impatiens and rhizoma nardostachyos by using ethanol, filtering, combining solution of ethanol, recovering the ethanol and concentrating into cream; drying the cream under reduced pressure and grinding to obtain fine powder; mixing the fine powder with auxiliary materials, preparing into soft materials by using the ethanol, and screening by using a 14-mesh screen to prepare granules; and drying, pelletizing and packaging the prepared granules so as to prepare the luodwei dorjie granules. The composition has the effects of clearing heat and releasing toxin, reducing swelling and easing pain and expelling wind and removing dampness, and is mainly used for treating gout. The decoction is inconvenient to decoct, carry and use; and oral liquid or an oral solid preparation stands for a certain time after high-speed centrifugation and alcohol precipitation, precipitates separate out, and the clarity and appearance of the preparation are influenced. In addition, the product is prepared into oral liquid, the oral liquid is bitter, and has low stability. Therefore, the granules in the oral solid preparations are adopted, the extracted medicaments are rapidly absorbed, and the product is small in volume, stable and is convenient to take.

Description

technical field [0001] The invention relates to the preparation of a traditional Chinese medicine, in particular to a Luodui Duoji granule with the function of treating gout and a preparation method thereof. Background technique [0002] Gout is a common civilized disease. In my country, more than 20% of people over the age of 30 have excessive uric acid, and 100% to 12% of people with excessive uric acid develop gout. As long as there are human beings on the earth, gout exists. [0003] There are many medicines for the treatment of gout at home and abroad at present, but most of them are western medicines, which can only treat the symptoms but not the root cause. The medicines are highly toxic and prone to relapse after treatment, and the overall effect of the treatment is not good. Tibet is one of the high-incidence areas of gout. With its unique theoretical system, Tibetan medicine has summed up a better drug for the treatment of gout in long-term application practice - ...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K9/16A61P19/06
Inventor 刘忠牛晓峰王聚乐李维凤顿珠袁瑞英卓玛东智张莉
Owner TIBET UNIV
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