Polyethylene oxide and matrix type surfactant in suppository composition

A polyoxyethylene and polyoxyethylene technology, which is applied in the directions of suppository delivery, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as unsatisfactory effects and the like

Inactive Publication Date: 2011-04-06
钟术光
View PDF3 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although surfactants are blended into suppositories based on fatty acid glycerides, the occurrence of the above process can be delayed to a certain extent, but the effect is often unsatisfactory

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Polyethylene oxide and matrix type surfactant in suppository composition
  • Polyethylene oxide and matrix type surfactant in suppository composition
  • Polyethylene oxide and matrix type surfactant in suppository composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The above-mentioned suppository composition will be described in detail below.

[0018] The fatty acid glyceride matrix used in the present invention can be, for example, fatty acid monoglyceride, fatty acid diglyceride, fatty acid triglyceride and their mixtures, where the fatty acid is usually pure or mixed with carbon atoms of C10-C18 Fatty acid, preferably pure or mixed fatty acid with carbon number of C14-C18, such as vegetable fatty acid obtained from coconut oil, olive oil. The melting point of these fatty acid glycerides is usually not lower than 25°C, preferably not lower than 37°C, but preferably not higher than 45°C, more preferably not higher than 42°C. Examples of fatty acid glycerides useful in the present invention are (manufactured by Gattefosse Co., Ltd), (manufactured by Dynamic Nobel Chemicals Co.Ltd), Pharmasol (manufactured by Nippon Oils and Fats), (manufactured by Aarhus), or (manufactured by Karlshamns) (manufactured by Cognis), (M...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a polyethylene oxide and application of a suppository matrix of which the molecular structure contains polyoxyethylene groups and C8-C24 alkyl in improving the stability of a suppository composition containing a fatty glyceride matrix. The invention also discloses a suppository composition of which the stability and the intracavity administration reservation functions are improved. The suppository composition comprises a fatty glyceride matrix, polyethylene oxide, a suppository matrix of which the molecular structure contains polyoxyethylene groups and C8-C24 alkyl anda suppository medicine, wherein the polyethylene oxide content is not lower than 1%, and the suppository matrix content is not lower than 10%.

Description

technical field [0001] The present invention relates to polyoxyethylene and its molecular structure containing polyoxyethylene (-(CH 2 CH 2 O) n -) and the suppository base of C8-C24 alkyl in the purposes of suppository composition. It also relates to a suppository composition with improved or improved stability and "intraluminal drug retention", more specifically, the suppository composition comprises a fatty acid glyceride matrix, and the content is not less than 1% of polyethylene oxide, The molecular structure with a content of not less than 10% contains polyoxyethylene (-(CH 2 CH 2 O) n -) and a suppository base of C8-C24 alkyl and a suppository drug. technical background [0002] Fatty acid glycerides are a common base for suppositories. However, suppositories based on fatty acid glycerides have "aging" characteristics, that is, the melting point often rises after a long-term storage period, and the melting properties change, such as not melting at body temperat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/34A61K9/02A61K45/00A61K47/10
Inventor 钟术光
Owner 钟术光
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap