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Preparation method of soapberry saponin

A technology of Sapindus japonica saponins and Sapindus japonicas, which is applied in the field of preparing Sapindus japonica saponins, can solve the problems that the purity cannot meet higher-level requirements, the pretreatment is troublesome, and the performance of the ultrafiltration membrane is greatly affected, and the cost is low. , the effect of large processing capacity and short extraction time

Inactive Publication Date: 2011-05-04
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wei Fengyu et al. "Ultrafiltration Separation and Purification of Sapindus saponins" reported the method of water extraction and ultrafiltration to purify Sapindus saponins, but the performance of impurity ultrafiltration membranes is greatly affected, and the pretreatment is troublesome.
Wei Fengyu et al. "Extraction and separation of natural Sapindus saponins" studied the conditions of water extraction-macroporous resin adsorption and separation, and obtained relatively good results, but the purity could not meet the higher-level requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 1kg of Sapindus chinensis crushed into 50 meshes and input it from one end of the extraction tube, add 5L of 70% ethanol solution from the feeding device at the other end of the extraction tube as the extraction solvent, start the spiral stirring and ultrasonic generator, the ultrasonic power is 30kHz, and extract for 30min After the liquid residue is separated, the separated Sapindus sapindus medicinal residue is subjected to ultrasonic extraction for the second time, the two extracts are combined, the ethanol is concentrated and recovered, and the activated carbon diatomaceous earth mixing column is applied while it is hot, the impurities are washed with water, and the saturated n-butanol aqueous solution is used to The sapindus saponins were eluted, and stopped after detecting no saponin by ultraviolet-visible light spectrophotometry, and the saponin was eluted and concentrated to a high concentration, and spray-dried to obtain 6.64 g of sapindus saponin with a co...

Embodiment 2

[0017] Take 1 kg of Sapindus chinensis crushed into 60 meshes and input it from one end of the extraction tube, add 6L of 80% ethanol solution from the feeding device at the other end of the extraction tube as the extraction solvent, start the spiral stirring and ultrasonic generating device, the ultrasonic power is 40kHz, and extract for 40min After the liquid residue is separated, the separated Sapindus chinensis medicinal residue is ultrasonically extracted once again, and the extracts are combined twice, concentrated to recover ethanol, put on an activated carbon diatomite mixing column while hot, wash the impurities with water, and wash with saturated n-butanol aqueous solution. The sapindus saponin was eluted, stopped after detecting no saponin by ultraviolet-visible light spectrophotometry, the saponin was eluted and concentrated to a high concentration, and spray-dried to obtain 7.26 g of sapindus saponin with a content of 89%.

Embodiment 3

[0019] Take 1kg of Sapindus chinensis crushed into 70 meshes and input it from one end of the extraction tube, add 8L of 90% ethanol solution from the feeding device at the other end of the extraction tube as the extraction solvent, start the spiral stirring and ultrasonic generator, the ultrasonic power is 28kHz, and extract for 60min After the liquid residue is separated, the separated Sapindus chinensis medicinal residue is ultrasonically extracted once again, and the extracts are combined twice, concentrated to recover ethanol, put on an activated carbon diatomite mixing column while hot, wash the impurities with water, and wash with saturated n-butanol aqueous solution. Sapindus saponin was eluted, and stopped after detecting no saponin by ultraviolet-visible light spectrophotometry, saponin was eluted and concentrated to a high concentration, and spray-dried to obtain 7.10 g of sapindus saponin with a content of 86%.

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Abstract

The invention relates to the technical field of medicines, in particular to a preparation method of soapberry saponin. The method comprises the following steps of: pulverizing the soapberry medicine material, extracting by using the cavatition of ultrasonic waves to prepare a soapberry saponin extracting solution, absorbing through an active carbon and diatomite mixed column, washing with water, eluting by using a saturated water solution of n-butanol, concentrating, and carrying out spray drying to obtain high-purity soapberry saponin. The preparation method of soapberry saponin has high yield and great handling amount, the production process saves energy resources and can continuous operate, and the produced soapberry saponin has high purity.

Description

Technical field: [0001] The invention relates to a method for preparing sapindus saponin from sapindus chinensis, in particular to a method for preparing sapindus saponin by ultrasonic extraction and active carbon diatomaceous earth mixed column separation. Background technique: [0002] Sapindus was first recorded in "Compendium of Materia Medica". It has the functions of clearing away heat and eliminating phlegm, eliminating accumulation and killing insects. Sapindus saponin (Soapnut Saponin) is the extract of the peel of wild deciduous tree Sapindus mukorossi Gareth. Its main surface active ingredients are triterpene saponins (I), sesquiterpene glycosides (II), fatty oil and protein. It is a natural non-ionic surfactant, a pure natural product, without adding any synthetic detergent agents, flavors, colorings and preservatives. It has a strong effect of reducing surface tension. It is used for skin cleaning (bathing, face washing, hand washing, shampooing) and clothes w...

Claims

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Application Information

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IPC IPC(8): A61K36/77A61P1/16A61P17/00A61P31/02A61P31/04A61P31/10A61P35/00
Inventor 刘东锋张翼杨成东
Owner NANJING ZELANG MEDICAL TECH
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