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Preparation method of carbonated silicon-containing HA (Hydroxyapatite) nano powder

A nano-powder and carbonation technology, which is applied in the field of medical biomaterials, can solve problems such as difficult to grasp, and achieve the effect of enhancing the alkalinity of the solution

Inactive Publication Date: 2011-05-04
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these silicon source materials are almost all organic compounds of silicon, which are easily hydrolyzed and floated, so the effective mixing of various liquids, that is, SiO 4 4- Effective alternative to PO 4 3- The problem is often difficult to grasp

Method used

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  • Preparation method of carbonated silicon-containing HA (Hydroxyapatite) nano powder
  • Preparation method of carbonated silicon-containing HA (Hydroxyapatite) nano powder
  • Preparation method of carbonated silicon-containing HA (Hydroxyapatite) nano powder

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Experimental program
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Effect test

Embodiment 1

[0030] 1) Weigh analytically pure Ca(OH) according to the stoichiometric Ca / (P+Si+C) molar ratio of 1.67 2 The powder is first dispersed with absolute ethanol, and then mixed with deionized water to prepare a 0.5mol / l solution under stirring, and ammonia water is added at the same time, and the pH value is adjusted to 10.8 to obtain a highly dispersed colloidal suspension a;

[0031] 2) According to the ratio of Si / (P+Si+C) molar percentage of 1.5% and C / (P+Si+C) molar percentage of 3%, respectively weigh Na 2 SiO 3 and Na 2 CO 3 , then Na 2 SiO 3 and Na 2 CO 3 Add deionized water to dissolve and prepare mixed solution b; meanwhile, prepare 0.3 mol / l of H with analytical reagents at a ratio of 95.5% by P / (P+Si+C) molar percentage 3 PO 4 solution c;

[0032] 3) Place the high-dispersion colloidal suspension liquid a in a temperature-regulated digitally controlled ultrasonic generator of the model KQ3200DDE. When the water temperature reaches 40°C, turn on the ultrasoni...

Embodiment 2

[0037] 1) Weigh analytically pure Ca(OH) according to the stoichiometric Ca / (P+Si+C) molar ratio of 1.67 2 The powder is first dispersed with absolute ethanol, and then mixed with deionized water to prepare a 0.5mol / l solution, and ammonia water is added at the same time to adjust the pH value to 11.0 to obtain a highly dispersed colloidal suspension a;

[0038] 2) According to the ratio of Si / (P+Si+C) molar percentage of 2% and C / (P+Si+C) molar percentage of 4%, respectively weigh Na 2 SiO 3 and Na 2 CO 3 , then Na 2 SiO 3 and Na 2 CO 3 Add deionized water to dissolve to prepare mixed solution b; at the same time, prepare 0.3 mol / l H with analytical reagents at a ratio of 94% P / (P+Si+C) molar percentage 3 PO 4 solution c;

[0039] 3) Put the high-dispersion colloidal suspension liquid a in a temperature-adjusted numerical control ultrasonic generator of the model KQ3200DDE. When the water temperature reaches 45°C, turn on the ultrasonic wave and stir it with a consta...

Embodiment 3

[0044] 1) Weigh analytically pure Ca(OH) according to the stoichiometric Ca / (P+Si+C) molar ratio of 1.67 2 The powder is first dispersed with absolute ethanol, and then mixed with deionized water to prepare a 0.5mol / l solution, and ammonia water is added at the same time, and the pH value is adjusted to 11.2 to obtain a highly dispersed colloidal suspension a;

[0045] 2) According to the ratio of Si / (P+Si+C) molar percentage of 4% and C / (P+Si+C) molar percentage of 8%, respectively weigh Na 2 SiO 3 and Na 2 CO 3 , then Na 2 SiO 3 and Na 2 CO 3 Add deionized water to dissolve and prepare mixed solution b, and prepare 0.3 mol / l of H with analytical reagents at a ratio of 88% according to the P / (P+Si+C) molar percentage. 3 PO 4 solution c;

[0046] 3) Put the high-dispersion colloidal suspension liquid a in a temperature-adjusted numerically controlled ultrasonic generator of the model KQ3200DDE. When the water temperature reaches 50°C, turn on the ultrasonic wave and s...

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Abstract

The invention relates to a preparation method of carbonated silicon-containing hydroxyapatite (CSi-HA) nano powder through ultrasonic coprecipitation, which comprises the following steps of: adjusting the pH value of a carbon source Ca(OH)2 to 10.5-11.5, maintaining stronger basicity and adding a phosphorus source, i.e. an H3PO4 solution, at constant temperature under the continuous action of ultrasonic waves to produce nascent state HA colloidal fluid with high purity and high dispersion degree; then, preparing a silicon source, i.e. Na2SiO3, and a carbon source, i.e. Na2CO3, in proportion into a mixed solution, continuing adding into the nascent state HA colloidal fluid at constant temperature under the continuous action of ultrasonic waves; and subsequently and continuously acting for certain time. The substitution of PO4<3-> with CO3<2-> and SiO4<4-> is effectively realized by using ultrasonic chemical action, and the carbonated silicon hydroxyapatite (CSi-HA) nano powder with high purity is obtained.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and in particular relates to an ultrasonic co-precipitation method for carbonated silicon-containing hydroxyapatite (CSi-HA) nanopowder. Background technique [0002] Hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 , Hydroxyapatite, referred to as HA] Compared with other biomaterials, its significant advantage is that its composition and structure are similar to the inorganic components of human bone tissue, containing calcium and phosphorus elements necessary for human tissue, and does not contain any harmful elements. After implanted into the human body, under the action of body fluids, calcium and phosphorus will be released from the surface of the material, absorbed by body tissues, and can form chemical bonds with human bone tissues to grow new tissues. Therefore, HA biomaterials have excellent bone tissue compatibility and bone tissue induction, and are widely recognized as hard tissue repair...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y40/00
Inventor 张超武王芬杨军肖玲段聪越
Owner SHAANXI UNIV OF SCI & TECH