High-efficiency acylation production method of L-methionine nonaqueous solution

A production method and a non-aqueous solution technology are applied in the field of high-efficiency production of L-methionine non-aqueous acylation, which can solve the problems that the traditional process cannot meet the requirements of economic indicators, the yield is low, the sewage discharge is large, and the comprehensive recycling process is reasonable and feasible. , the effect of purifying the environment and promoting ecological balance

Inactive Publication Date: 2011-05-11
SHANDONG YANGCHENG BIOLOGY TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 1. The yield is low, and the acylation yield is generally 120-122%;
[0008] 2. The amount of sewage discharge is large, generally about 5 tons of water per ton of product;
[0009]

Method used

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  • High-efficiency acylation production method of L-methionine nonaqueous solution

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0027] Example 1

[0028] (1) Take 50kg of DL-methionine and dissolve it in 200kg of acetic acid solution, add 55kg of acetic anhydride dropwise to carry out the acylation reaction to generate acylated DL-methionine; the temperature of the acylation reaction is 50°C and the time is 6 hours.

[0029] (2) The acylated DL-methionine solution is recovered by vacuum distillation of acetic acid. After recovering the acetic acid, add 1 / 6 volume of water to turn unreacted acetic anhydride into acetic acid. Continue to recover the acetic acid, and then add water to extract most of the remaining acetic acid to obtain The acylated DL-methionine solution was concentrated, and the content of acylated DL-methionine was 20% by weight.

[0030] (3) Concentrated acylated DL-methionine solution was added with 2kg aminoacylase Miqu enzyme (liquid), and the resolution reaction was carried out at a constant temperature (36°C). After the resolution reaction, the reaction solution was decolorized and conce...

Example Embodiment

[0033] Example 2

[0034] (1) Take 50kg of DL-methionine and dissolve it in 250kg of acetic acid solution, add 60kg of acetic anhydride dropwise to carry out the acylation reaction to generate acylated DL-methionine; the temperature of the acylation reaction is 60°C and the time is 5 hours.

[0035] (2) The acylated DL-methionine solution is recovered by vacuum distillation of acetic acid. After recovering the acetic acid, add 1 / 5 volume of water to turn unreacted acetic anhydride into acetic acid, continue to recover the acetic acid, and then add water to extract most of the remaining acetic acid to obtain Concentrate the acylated DL-methionine solution, the content of acylated DL-methionine is 25% by weight.

[0036] (3) Concentrated acylated DL-methionine solution was added with 2kg aminoacylase Miqu enzyme (liquid), and the resolution reaction was carried out at a constant temperature (38°C). After the resolution reaction was completed, the reaction solution was decolorized and c...

Example Embodiment

[0039] Example 3

[0040] (1) Take 50kg of DL-methionine and dissolve it in 280kg of acetic acid solution, add 65kg of acetic anhydride dropwise to carry out the acylation reaction to generate acylated DL-methionine; the temperature of the acylation reaction is 65°C and the time is 4 hours.

[0041] (2) The acylated DL-methionine solution is recovered by vacuum distillation of acetic acid. After recovering the acetic acid, add 1 / 4 volume of water to turn unreacted acetic anhydride into acetic acid. Continue to recover the acetic acid, and then add water to extract most of the remaining acetic acid to obtain Concentrate the acylated DL-methionine solution, and the content of acylated DL-methionine is 30% by weight.

[0042] (3) Concentrated acylated DL-methionine solution was added with 2kg aminoacylase Miquase (liquid), and the resolution reaction was carried out at a constant temperature (40°C). After the resolution reaction was completed, the reaction solution was decolorized and c...

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Abstract

The invention relates to a high-efficiency acylation production method of an L-methionine nonaqueous solution. The novel process is bold in innovation and is mainly a bold reformation to an acylation process. The method comprises the following steps of: directly dripping acetic anhydride into DL-methionine for carrying out an acylation reaction by using acetic acid as a reaction solution, and after the reaction ends, evaporating to recover the acetic acid; directly adding water to acetyl DL-methionine to regulate the pH value without crystallizing; adding biological catalysis enzyme, inorganic catalysis enzyme, and the like; and entering a split procedure. The method is characterized in that the yield of the L-methionine nonaqueous solution reaches 126-128 percent, the sewage discharge quantity is reduced by 2/3, and the total yield of the L-methionine nonaqueous solution is improved to 60 percent. The process has reasonable and feasible comprehensive cycle process, conforms to a green and environmental protection idea, purifies the environment, promotes the ecological balance, reduces the production cost and enhances the social and economic benefits.

Description

technical field [0001] The invention relates to a production method of L-methionine, an important intermediate of food and medical products, in particular to a high-efficiency production method of non-aqueous solution acylation of L-methionine. Background technique [0002] L-methionine: also known as L-formic acid; L-methionine, English name L-Methionine. L-methionine is white flake crystal or powder, L-methionine is soluble in water (5.6g / 100ml, 30 degrees), warm dilute ethanol, alkaline solution and dilute inorganic acid. Hardly soluble in ethanol, almost insoluble in ether, its molecular formula is C5H11N02S; molecular weight: 149.21; CAS NO.: 63-68-3, and its chemical structure is as follows: [0003] [0004] L-methionine is widely used in various fields such as medicine, food, biochemical reagents and daily life. L-methionine is used in biochemical research and nutritional supplements, and is also used in the adjuvant treatment of pneumonia, cirrhosis and fatty l...

Claims

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Application Information

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IPC IPC(8): C12P41/00C12P13/12
Inventor 王东阳闫汝东蔡传康
Owner SHANDONG YANGCHENG BIOLOGY TECH CO LTD
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