Method for measuring kin physiology parameters and optical property parameters based on reflective spectral measurement

A technology of optical characteristic parameters and physiological parameters, which is applied in the field of spectral technology application and biomedical engineering, and can solve the problems of unsatisfactory tissue uniformity, poor implementability, and complex structure of skin tissue

Active Publication Date: 2012-10-31
HUAZHONG UNIV OF SCI & TECH
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  • Application Information

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Problems solved by technology

(See F. Bevilacqua, D. Piguet, etc., "In vivolocal determination of tissue optical properties: applications to human brain". Applied Optics, 1999) In order to obtain better absorption and scattering resolution, a larger measurement range is required, but The complexity of skin tissue structure makes large-scale measurements unable to meet the conditions of tissue homogeneity
Therefore, it is difficult to apply on skin tissue
The time-domain method for measuring tissue optical properties requires the use of a pulsed laser and a detector with a time-resolution capability on the order of picoseconds, (see B.J.Tromberg, N.Shah, etc., "Non-Invasive In Vivo Characterization of Breast Tumors Using Photon Migration Spectroscopy" , Neoplasia, 2000) The equipment is expensive and the implementability is poor

Method used

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  • Method for measuring kin physiology parameters and optical property parameters based on reflective spectral measurement
  • Method for measuring kin physiology parameters and optical property parameters based on reflective spectral measurement
  • Method for measuring kin physiology parameters and optical property parameters based on reflective spectral measurement

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Experimental program
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Effect test

Embodiment 1

[0128] Embodiment 1: Composition of reflection spectrum measurement system

[0129] see figure 1 , introducing the structural composition of the system for measuring skin physiological parameters and optical characteristic parameters based on reflectance spectroscopy:

[0130] The measurement system of the skin reflection spectrum includes a measurement device of the skin reflection spectrum and a calculation and display device, wherein the measurement device of the skin reflection spectrum includes 1, a wide-spectrum light source; 2, a spectrum detector; 3, an incident optical fiber; 4, a reflection probe; 5 , receiving optical fiber; 6, reflection probe bracket; 7, data transmission line; the calculation and display device is composed of an analog-to-digital conversion module, a calculation module, a memory, a display processing module, a display, and a data bus. Since the light intensity fluctuation of the halogen tungsten lamp under the stable voltage is small and the co...

Embodiment 2

[0132] Embodiment 2: Measurement process of skin physiological parameters and optical characteristic parameters

[0133] In actual application, the reflected light intensity optimization data T including a large amount of experimental and Monte Carlo simulation data has been recorded and stored in the storage unit of the computing and display device. The process of using the device to measure tissue physiological parameters and optical characteristic parameters is as follows:

[0134] 1) Connect the components of the device, place the reflection probe vertically on the clean and flat surface of the skin to be tested, and record the skin reflection light intensity M(λ);

[0135] 2) Place the reflection probe vertically at a fixed distance d above the reflection standard sheet, and record the reflection light intensity M of the standard sheet std (λ);

[0136] 3) Then the normalized measured skin reflectance spectrum is mSPR ( λ ...

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Abstract

The invention provides a method and system for measuring skin physiology parameters and optical property parameters based on reflective spectral measurement. The measuring system is composed of measuring equipment for a skin reflection spectrum and a computation and display device. By utilizing an analysis method of combining experimental data with the Monte Carlo simulation, the measuring systemprovides more accurate corresponding data of reflection light intensity and skin optical property; during the practical measurement of sample skin, on the basis of a practically measured reflection spectrum, the data and more physiology parameters are calculated and fit to obtain the skin physiology parameters and the optical property parameters based on reflective spectral measurement; finally, the optical property parameters of the skin adsorption coefficient mu a, a reduction scattering coefficient mu s' and the like as well as physiological information, such as melanin content, deoxygenated haemoglobin content, oxygenated haemoglobin content, moisture content and the like are also measured are measured in real time in a non-invasive and lossless mode.

Description

technical field [0001] The invention belongs to the fields of spectral technology application and biomedical engineering, and relates to a method for measuring skin physiological parameters and optical characteristic parameters based on reflection spectrum measurement. Background technique [0002] In recent years, the use of optical means for medical diagnosis and treatment has gradually attracted widespread attention of biomedical researchers. Compared with other medical detection technologies such as X-ray, CT, and nuclear magnetic resonance, optical technology can implement non-invasive structure and function detection of tissues in a non-invasive manner, and has the advantages of wide application range, high portability, and low cost. The parameters of tissue optical properties describe the response of biological tissue to incident light of different wavelengths by evaluating the optical properties of tissue such as absorption and scattering. Quantitative evaluation of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00
Inventor 骆清铭闻翔
Owner HUAZHONG UNIV OF SCI & TECH
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