Application and blood-sugar lowering effective part of trapa acornis nakano shell as well as extraction method of blood-sugar lowering effective part

A technology of effective parts and extraction method, which is applied to the effective parts of Nanhuling for hypoglycemic and its extraction, can solve the problems of high cost, few manufacturers, intestinal side effects, etc.

Inactive Publication Date: 2011-05-25
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the cost of existing drugs of this type is high, there are f

Method used

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  • Application and blood-sugar lowering effective part of trapa acornis nakano shell as well as extraction method of blood-sugar lowering effective part
  • Application and blood-sugar lowering effective part of trapa acornis nakano shell as well as extraction method of blood-sugar lowering effective part
  • Application and blood-sugar lowering effective part of trapa acornis nakano shell as well as extraction method of blood-sugar lowering effective part

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The effective part of Nanhu water chestnut shell with hypoglycemic effect is selected from the petroleum ether part, ethyl acetate part or n-butanol part of the methanol extract of Nanhu water chestnut shell.

[0022] The method for extracting the effective part of the above-mentioned Nanhu water chestnut shell comprises the following steps: take 1000 g of dried Nanhu water chestnut shell and crush, add 5 times of methanol aqueous solution (80% volume fraction) to soak and extract 3 times, each time for 3 days, combine the immersion liquid and Concentrate into an extract; sequentially extract the extract with petroleum ether (3000ml), ethyl acetate (3000ml), and n-butanol (3000ml), each for three times; evaporate the solvent to obtain the petroleum ether part of Nanhu water chestnut shell ( TAPE), ethyl acetate site (TAEA) or n-butanol site (TABU). The corresponding yields of different solvents are shown in the table 1 .

[0023] The application of Nanhu water chestnu...

Embodiment 2

[0025] The effective part of Nanhu water chestnut shell with hypoglycemic effect is selected from the petroleum ether part, ethyl acetate part or n-butanol part of the ethanol extract of Nanhu water chestnut shell.

[0026] The method for extracting the effective parts of the above-mentioned Nanhu water chestnut shell includes the following steps: take 3000 g of dried Nanhu water chestnut shell and crush it, add 6 times of ethanol aqueous solution (70% volume fraction) to soak and extract twice, each time for 3 days, combine the infusion and concentrate into an extract; the extract is divided into three parts, and the extract is extracted with petroleum ether (3200ml), ethyl acetate (3200ml), and n-butanol (3200ml) respectively, and each extraction is performed three times; the solvent is evaporated to obtain Nanhu Petroleum ether part (TAPE), ethyl acetate part (TAEA) or n-butanol part (TABU ) of diamond shell.

[0027] The application of Nanhu water chestnut shell in the pre...

Embodiment 3

[0029] The effective part of Nanhu water chestnut shell with hypoglycemic effect is selected from the petroleum ether part, ethyl acetate part or n-butanol part of the methanol extract of Nanhu water chestnut shell.

[0030]The method for extracting the effective part of the above-mentioned Nanhu water chestnut shell includes the following steps: take 1000 g of dried Nanhu water chestnut shell and crush it, add 5 times of methanol aqueous solution (60% volume fraction) to soak and extract 4 times, each time for 3 days, combine the infusion and concentrate into an extract; sequentially extract the extract with petroleum ether (3000ml), ethyl acetate (3000ml), and n-butanol (3000ml), each extracting three times; evaporate the solvent to obtain the petroleum ether part of Nanhu water chestnut shell (TAPE ), ethyl acetate site (TAEA) or n-butanol site (TABU ).

[0031] Application of Nanhu water chestnut shell in the preparation of hypoglycemic drugs: Take 334 g of Nanhu water che...

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Abstract

The invention provides application and blood-sugar lowering effective part of trapa acornis nakano shell as well as an extraction method of the blood-sugar lowering effective part, belonging to the technical field of traditional Chinese medicine. The new application of the trapa acornis nakano shell is to prepare a blood-sugar lowering medicine. The blood-sugar lowering effective part of the trapa acornis nakano shell is selected from one or any composite of petroleum ether part (TAPE), ethyl acetate part (TAEA) and n-butyl alcohol part (TABU) of the alcohol extract of trapa acornis nakano shell. The extraction method of the effective part comprises the following steps: grinding the dried trapa acornis nakano shell, carrying out digestion on the trapa acornis nakano shell powder with the aqueous solution of methyl alcohol or ethanol, and concentrating the immersion liquid to obtain extract; extracting the extract with petroleum ether, ethyl acetate or n-butyl alcohol for three times respectively; and volatilizing the dissolvent to obtain the TAPE, the TAEA or the TABU of the trapa acornis Nakai shell. Each effective part has good activity in inhibiting alpha-glucuroide. In vitro tests prove that TAEA and TABU have relatively good therapeutic effect on mice suffering from diabetic induced by mesoxyalyurea.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, relates to a new application of the plant Nanhu water chestnut, and also relates to an effective hypoglycemic part of the Nanhu water chestnut and an extraction method thereof. Background technique [0002] Nanhu Ling ( Trapa acornis Nakano) is a plant of the genus Lingaceae, which is a special aquatic vegetable in my country. It is named after it is produced in Nanhu Lake, Jiaxing, Zhejiang. Nanhu water chestnut is different from other water chestnuts. It has the characteristics of no edges and corners, thin shell, tender texture, and high water content. It tastes sweet and juicy, cool and thirst-quenching, and contains a variety of amino acids, vitamins and minerals. [0003] At home and abroad, there are many studies on Nanhu water chestnut, which belongs to water chestnut, but there are few studies on Nanhu water chestnut. Domestic research mainly focuses on biology, re...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P3/10A61K131/00
Inventor 康文艺魏金凤黄嬛李园园
Owner HENAN UNIVERSITY
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