Applications of compound salvia tablet in inhibiting smooth muscle cell proliferation and preventing and treating vessel restenosis

A compound danshen tablet and restenosis technology, applied in the field of compound danshen tablet, can solve the problems of vascular restenosis, limit the long-term curative effect, etc., and achieve the effects of inhibiting proliferation, improving the quality of life, and improving the long-term curative effect.

Inactive Publication Date: 2011-05-25
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, about 30% to 50% of patients will experience vascular restenosis 3 to 6 months after percutaneous transluminal coronary angioplasty (PTCA), which greatly limits its long-term efficacy.

Method used

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  • Applications of compound salvia tablet in inhibiting smooth muscle cell proliferation and preventing and treating vessel restenosis
  • Applications of compound salvia tablet in inhibiting smooth muscle cell proliferation and preventing and treating vessel restenosis
  • Applications of compound salvia tablet in inhibiting smooth muscle cell proliferation and preventing and treating vessel restenosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] [Example 1] The effect of continuous administration of Compound Danshen Tablets of different concentrations for 7 days on vascular intimal hyperplasia

[0017] 1. SD rat culture

[0018] Thirty-six healthy adult male SD rats, weighing 220±20 g, were selected and purchased from the Animal Experiment Center of the Academy of Military Medical Sciences. Rats were kept in an SPF grade experimental environment.

[0019] 2. Effects of different concentrations of Compound Danshen Tablets on vascular intimal hyperplasia

[0020] Preparation of animal model: intraperitoneal injection of 2% pentobarbital sodium 40mg / kg for anesthesia, after anesthesia, rats were fixed on a surgical fixation board, a median neck incision was made, the left artery was exposed layer by layer, and the external carotid artery was ligated Insert the 2F (0.16mm) balloon catheter into the common carotid artery through the left external carotid artery to the starting part, inject air into the balloon, an...

Embodiment 2

[0028] [Example 2] Effects of different concentrations of compound danshen tablets administered continuously for 14 days on vascular intimal hyperplasia

[0029] 1. SD rat culture

[0030] Thirty-eight healthy adult male SD rats, weighing 220±20 g, were purchased from the Animal Experiment Center of the Academy of Military Medical Sciences. Rats were kept in an SPF grade experimental environment.

[0031] 2. The effect of giving different concentrations of Compound Danshen Tablets on vascular intimal hyperplasia

[0032] Preparation of animal model: intraperitoneal injection of 2% pentobarbital sodium 40mg / kg for anesthesia, after anesthesia, rats were fixed on a surgical fixation board, a median neck incision was made, the left artery was exposed layer by layer, and the external carotid artery was ligated Insert the 2F (0.16mm) balloon catheter into the common carotid artery through the left external carotid artery to the starting part, inject air into the balloon, and pull...

Embodiment 3

[0040] [Example three] Improve the impact of the content of ginsenoside Rg1, ginsenoside Rb1, tanshinone II A sodium sulfonate monomer on vascular intimal hyperplasia in Compound Danshen Tablets

[0041] 1. SD rat culture

[0042] Forty-two healthy adult male SD rats, weighing 220±20 g, were selected and purchased from the Animal Experiment Center of the Academy of Military Medical Sciences. Rats were kept in an SPF grade experimental environment.

[0043]2. Effects of ginsenoside Rg1, ginsenoside Rb1, and tanshinone IIA sodium sulfonate monomers added to Compound Danshen Tablets on vascular intimal hyperplasia

[0044] Preparation of animal model: intraperitoneal injection of 2% pentobarbital sodium 40mg / kg for anesthesia, after anesthesia, rats were fixed on a surgical fixation board, a median neck incision was made, the left artery was exposed layer by layer, and the external carotid artery was ligated Insert the 2F (0.16mm) balloon catheter into the common carotid artery...

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Abstract

The invention relates to a compound salvia tablet and applications thereof in inhibiting vascular smooth muscle cell proliferation and preventing and treating restenosis after coronary angioplasty by increasing contents of monomers (ginsenoside Rg1 and sodium tanshinone IIA sulfonate) in the compound salvia tablet. The experiment proves that the compound salvia tablet can effectively inhibit vascular smooth muscle cell proliferation, prevent and treat intimal proliferation after angioplasty, increase the contents of the monomers (sodium tanshinone IIA sulfonate and ginsenoside Rg1) in the compound salvia tablet, and effectively inhibit intimal proliferation. The effect of the compound salvia tablet is superior to the effect of the same dose of the compound salvia tablet in the prior art.

Description

technical field [0001] The invention relates to Compound Danshen Tablets and the use of increasing the content of two monomers, ginsenoside Rg1 and sodium tanshinone IIA sulfonate in Compound Danshen Tablets, to inhibit the proliferation of smooth muscle cells and prevent restenosis after coronary angioplasty (PTCA) . Background technique [0002] Compound Danshen Tablets are made of three traditional Chinese medicines, Danshen, Panax notoginseng, and Borneol. It has the functions of promoting blood circulation and removing blood stasis, regulating qi and relieving pain. Tanshinone IIA is the fat-soluble component of Salvia miltiorrhiza, and its sodium sulfonate salt has been used to make injections for clinical use in China. Ginsenoside Rg1 and Ginsenoside Rb1 are the main active ingredients in Panax notoginseng saponins, which are extracted from the tap root of Panax notoginseng, which can increase cerebral blood flow, improve microcirculation, and reduce blood viscosity....

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P9/00A61P9/10A61K31/045
Inventor 王升启赵海峰崔向君潘从泽王云飞
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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