Immature bitter orange or bitter orange total flavonoids extract prepared by ethanol reflux and extraction and application thereof

Abstract

The invention relates to an immature bitter orange or bitter orange total flavonoids extract, which is prepared by the following steps of: cutting bitter orange or bitter orange into slices or crushing bitter orange or bitter orange, adding 30 to 90 percent ethanol of 5 to 16 times volume for reflux and extraction for 1 to 3 times and 1 to 3 hours every time, and filtering; and combining the filtrate, reclaiming the ethanol from the filtrate, filling the aqueous solution into the treated non-polar macroporous resin, diluting in turn by using water and less than 20 percent ethanol to remove impurities, diluting by using 25 to 90 percent ethanol and 0.5 to 2 percent sodium hydroxide, collecting ethanol eluent, concentrating the ethanol eluent under reduced pressure to obtain fluid extract with relative density of about 1.20 to 1.40 (50 to 70 DEG C), drying the fluid extract under the reduced pressure at the temperature of between 60 and 80 DEG C, and crushing to obtain the immature bitter orange or bitter orange total flavonoids extract. The extract can be used for preparing medicaments for gastrointestinal motility disorder type functional indigestion, epigastric pain, abdominal distention, asitia, belching, nausea, sickness and chemotherapy or sickness caused by other reasons.

Description

technical field [0001] The invention relates to a total flavonoid extract of Fructus aurantium or Fructus aurantii extracted by ethanol reflux and use thereof. Background technique [0002] Functional dyspepsia (FD) is a common and frequently-occurring disease. Also known as gastric hypomotility, or gastric motility disorder. Is a common clinical syndrome, foreign statistics show that 1 / 3 of the population suffered from FD, accounting for 20% to 30% of outpatients. Domestically, it accounts for about 50% of digestive system outpatients, and occurs in 20% to 40% of normal people. In addition, more than 80% of cancer patients will cause vomiting after chemotherapy. The main anti-vomiting drugs are Metoclon and Zofran, but chemical drugs are accompanied by fatigue, dizziness, headache, and even neck and back muscle pain. Cramp symptoms. [0003] At present, Western medicine mainly treats modinline, cisapride, mosapride, etc.; however, with the extensive use of them, it is...

AI Technical Summary

Problems solved by technology

However, Citrus aurantium and Fructus aurantium are only used in a small amount in clinical formulas and Chinese patent medicine preparations, and a large amount of resources have not been widely used. Their natural effects of breaking Qi and eliminating stagnation may not be fully exploited in the similarity with modern gastric motility-promoting drugs.

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