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Anti-platelet adhesion material

An adhesive material, anti-platelet technology, applied in catheters, coatings, etc., can solve problems such as platelet adhesion

Inactive Publication Date: 2013-07-17
FAR EASTERN NEW CENTURY COPRRATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although PU has higher biocompatibility than other polymer materials, it still causes platelets to adhere to form thrombus

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0035] synthetic chemicals

[0036] Diphenylmethane 4,4'-diisocyanate (MDI, 98%), hydrogenated diphenylmethane diisocyanate (H 12 MDI, 90%), isophorone diisocyanate (IPDI, 98%), polyethylene glycol (PEG; Avg.Mn about 2000), 1,4-butanediol (1,4-Butanediol, BD, 99 %), urea (urea, 99.0-100.5%), polyethyleneimine (Polyethyleneimine, PEI) were purchased from Sigma (Sigma); Eastman (Eastman) 58245 was purchased from Noveon; dimethyl Acetamide (Dimethyl acetamide, DMAC, reagent grade) was purchased from TEDIA, and fresh DMAC was obtained by distillation before the reaction, and then the reaction was carried out.

[0037] Synthetic preparation of PTU

preparation example 1

[0038] Preparation Example 1: Synthetic PTU containing 15% urea (PTU1)

[0039] Take 1 equivalent of polyethylene glycol in a 500mL four-necked reaction bottle, put it in a vacuum oven and heat it to 100°C before the reaction, remove water under a vacuum of 1 torr for 8 hours, add 30mL of fresh DMAC, and again at 60°C , to remove water for 2 hours under a vacuum of 1 Torr. Add 2.4 equivalents of 1,4-butanediol, raise the temperature to 80°C, and reach temperature equilibrium in about half an hour, then add 0.6 equivalents of urea, and then add 4 equivalents of MDI to carry out the polymerization reaction. MDI must be added in portions, each time The amount added is 0.02 to 0.05 equivalent. In addition, when MDI is added, the viscosity will rise. At this time, DMAC must be added to dilute to prevent gel (gel). Repeat the cycle step of "adding MDI, waiting for the viscosity of the polymer to rise, and diluting". After rising again, methanol was added to stop the reaction, and ...

preparation example 2

[0040] Preparation Example 2: Synthetic PTU containing 25% urea (PTU2)

[0041] Take 1 equivalent of polyethylene glycol in a 500mL four-neck reaction bottle, put it in a vacuum oven and heat it to 100°C before the reaction, remove water under a vacuum of 1 torr for 8 hours, add 30mL of fresh DMAC, and again at 60°C , to remove water for 2 hours under a vacuum of 1 Torr. Add 2 equivalents of 1,4-butanediol, raise the temperature to 80°C, and reach temperature equilibrium in about half an hour, then add 1 equivalent of urea, and then add 4 equivalents of MDI to carry out the polymerization reaction. MDI must be added in portions, each time The amount added is 0.02 to 0.05 equivalent. In addition, when MDI is added, the viscosity will rise. At this time, DMAC must be added to dilute to prevent gel (gel). Repeat the cycle step of "adding MDI, waiting for the viscosity of the polymer to rise, and diluting". After rising again, methanol was added to stop the reaction, and the pro...

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PUM

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Abstract

The invention provides an anti-platelet adhesion material, which essentially comprises triuret polyurethane randomly composed of constitutional repeating units shown as formulas (I), (II), and (III). When the total number of the three constitutional repeating units is 100, the proportion of the constitutional repeating unit (I) is about 5 to 50, wherein every R is independently an alkylene of C2 to C16, an aromatic group of C6-C30, or an alicyclic group of C6-C30; n is an integer from 2 to 16; and p is an integer from 3 to 150.

Description

technical field [0001] The present invention relates to a novel anti-platelet adhesion polyurethane material, which can be applied in the technical field of medical equipment, especially as the main body material of medical catheter or the surface treatment resin of medical catheter, so as to achieve the effect of anti-platelet adhesion . Background technique [0002] Under normal conditions in the human body, blood will not coagulate or block. However, when foreign objects such as medical polymer materials invade the human body, the flow state of the blood and the properties of the blood vessel walls will change. In addition, if the material itself has dissolved substances (such as acidic and alkaline substances) entering the blood, it will also change the properties of the blood. These factors are very likely to trigger the formation of blood clots and blockage of blood vessels. This phenomenon often occurs during the treatment of patients, which will also bring great hid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/06A61L29/08C08G18/66
Inventor 蔡英男张根源纪法成陈柏仰吴政达
Owner FAR EASTERN NEW CENTURY COPRRATION