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Method for extracting panax notoginseng saponins by using continuous countercurrent ultrasonic extraction combined film technology

A technology of total Panax notoginseng saponins and countercurrent ultrasound, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problem of severe foaming of Panax notoginseng saponins, difficulty in forming a large concentration difference, and difficulty in ultrasonic waves being effective. problems such as conduction, to achieve the effect of shortening the extraction cycle, reducing energy consumption, and preventing hydrolysis

Active Publication Date: 2011-06-22
YUNNAN PHYTOPHARML +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the attenuation of ultrasonic waves in the ultrasonic extraction process of Panax notoginseng saponins in the prior art, and the defects that ultrasonic waves are difficult to effectively conduct, resulting in difficulty in realizing industrialization and forming a large concentration difference, and the extraction efficiency is not high. And the high vacuum and low temperature concentration has high requirements on equipment, the total saponins of Panax notoginseng foams violently, and is easy to flush, which leads to repeated concentration and other shortcomings.

Method used

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  • Method for extracting panax notoginseng saponins by using continuous countercurrent ultrasonic extraction combined film technology
  • Method for extracting panax notoginseng saponins by using continuous countercurrent ultrasonic extraction combined film technology
  • Method for extracting panax notoginseng saponins by using continuous countercurrent ultrasonic extraction combined film technology

Examples

Experimental program
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Effect test

Embodiment 1

[0058] Take 30 kg of Panax notoginseng cut coarse powder, feed it from the inlet of the continuous countercurrent ultrasonic extraction tube head, add 8 times the amount of 75% ethanol (240kg) from the solvent inlet at the tail of the continuous countercurrent ultrasonic extraction tube, and perform continuous countercurrent ultrasonic extraction , set the ultrasonic frequency to 40KHz, set the ultrasonic temperature to 20°C, conduct continuous countercurrent ultrasonic extraction for 20 minutes, collect the ethanol ultrasonic extract, filter, the filtrate temperature is 20°C, and the filtrate is concentrated with a nanofiltration membrane with a relative molecular weight cut-off of 100-400, and the operating pressure When it reaches 0.2MPa, the permeate flows out, and the flow rate is very slow. Increase the operating pressure to 2.9MPa, and the flow rate is stable until there is no permeate flow out. Add water to the membrane concentrate until the alcohol content reaches 15%, ...

Embodiment 2

[0060] Take 30 kg of Panax notoginseng coarse powder, feed it from the feed inlet at the head of the continuous countercurrent ultrasonic extraction tube, add 15 times the amount of 40% ethanol (450kg) from the solvent inlet at the tail of the continuous countercurrent ultrasonic extraction tube, and perform continuous countercurrent ultrasonic extraction. Set the ultrasonic frequency to 20KHz, set the ultrasonic temperature to 50°C, conduct continuous countercurrent ultrasonic extraction for 60 minutes, collect the ultrasonic extract, filter, the filtrate temperature is 50°C, and the filtrate is concentrated with an ultrafiltration membrane with a relative molecular weight cut-off of 1000, when the operating pressure reaches 0.1MPa , there is a permeate outflow, the flow rate is very slow, increase the operating pressure to 0.4MPa, the flow rate is stable, until the membrane is concentrated and there is no permeate outflow, the membrane concentrate is decompressed until it has ...

Embodiment 3

[0062] Take 30 kg of Panax notoginseng cut coarse powder after soaking and wetting with 20% ethanol, feed it from the inlet of the continuous countercurrent ultrasonic extraction tube head, and add 6 times the amount of 90% ethanol from the solvent inlet at the tail of the continuous countercurrent ultrasonic extraction tube ( 180kg), carry out continuous countercurrent ultrasonic extraction, set the ultrasonic frequency to 80KHz, set the ultrasonic temperature to 30°C, conduct continuous countercurrent ultrasonic extraction for 40min, collect the ultrasonic extract, filter, the filtrate temperature is 30°C, and the filtrate is ultrafiltered with a relative molecular weight cut-off of 25,000 Membrane concentration, when the operating pressure reaches 0.1MPa, the permeate flows out, and the flow rate is very slow. Increase the operating pressure to 0.7MPa, and the flow rate is stable. When the membrane is concentrated, there is no permeate flow out, and the membrane concentrate i...

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Abstract

The invention discloses a method for extracting panax notoginseng saponins by using a continuous countercurrent ultrasonic extraction combined film technology, belonging to the technical field of extraction and separation of plant effective components. The method mainly comprises the following steps of: adding 40-90 percent ethanol having 6-15 times by weight of the pseudo-ginseng crude powder and carrying out continuous countercurrent ultrasonic extraction for 20-120min at a temperature of 20-50 DEG C with the ultrasonic frequency of 20-80KHz; carrying out membrane concentration on filtering liquid by using 1,000-2,500 parts of ultrafiltration membrane or 100-800 parts of nanofiltration membrane at 20-50 DEG C under 0.4-4.1MPa; adding water into the liquid for diluting after the filtering liquid is subjected to pressure reduction and concentrating to be alcohol-free, or directly adding water for diluting; filtering macroporous adsorption resins and eluting with water, and eluting by using 50-90 percent ethanol; carrying out membrane concentration on peralkaline anion resins by using 100-800 parts of nanofiltration membrane under 0.4-4.1MPa; decoloring; carrying out pressure reduction and concentration; and spray-drying. With low-temperature extraction, high extraction ratio, continuous production and high purification ratio, the quality of the product is guaranteed and the method is simple.

Description

technical field [0001] The invention belongs to the technical field of extraction and separation of plant effective components, and in particular relates to a method for extracting total saponins of Panax notoginseng by continuous countercurrent ultrasonic extraction combined with membrane technology. Background technique [0002] Panax notoginseng is a plant of the genus Panax notoginseng of Araliaceae ( Panax notoginseng (Burk.) F. H. Chen) is a rare and precious Chinese medicinal material unique to China. Mainly produced in Wenshan, Yunnan, it is known as the "holy medicine for regulating blood", which can dispel blood stasis and stop bleeding, reduce swelling and relieve pain. For hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic bleeding, chest and abdomen stabbing pain, swelling and pain from falls. Panax notoginseng saponins are its main active ingredients. Modern pharmacological experiments have proved that panax notoginseng saponins can in...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P9/10A61P9/12A61P9/00A61P39/00A61P7/02A61P7/04A61P29/00A61K125/00
Inventor 武正才李文赵锋宁李明杰黄春球
Owner YUNNAN PHYTOPHARML
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