Unlock instant, AI-driven research and patent intelligence for your innovation.

Pharmaceutical composition and preparation method thereof

A technology of composition and medicine, which is applied in the field of pharmaceutical composition and its preparation, can solve problems such as not having much practical value, being unable to be used in the human body, and having poor stability

Active Publication Date: 2013-04-03
SICHUAN KELUN PHARMA RES INST CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solve the problem of poor stability of the existing soft capsules due to ethanol
However, at present, isopropyl myristate cannot be used in the human body at home, and it is mainly used in cosmetics and a small amount of topical preparations abroad, so in fact, this invention does not have much practical value
In the document "Research on the Phase Diagram of Etoposide Microemulsion", Isopropyl myristate is also used, which has the same problem; and etoposide has poor stability and is not suitable for long-term placement in an aqueous solution environment, so The practicality of the invention is debatable
[0006] In addition, the existing etoposide soft capsules also have a very obvious disadvantage - large individual differences and low bioavailability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition and preparation method thereof
  • Pharmaceutical composition and preparation method thereof
  • Pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] Caprylic acid triglyceride 1g Macrogol 400 2.5g

[0096] Malic acid 0.1g Polyoxyethylene ether (35) castor oil 2.7g

[0097] Etoposide 0.4g

[0098] Weigh caprylic acid triglyceride, polyethylene glycol 400, polyoxyethylene ether (35) castor oil and malic acid, mix well, add etoposide, stir and dissolve in a water bath at 60°C to obtain etoposide pre-emulsified concentrated liquid.

Embodiment 2

[0100] Linoleoyl macrogol glyceride 0.7g Tween60 6g

[0101] Etoposide 0.41g Macrogol 400 3g

[0102] Tartaric acid 0.1g

[0103] Weigh linoleoyl macrogol glyceride, polyethylene glycol 400, Tween60 and tartaric acid, mix well, add etoposide, stir and dissolve in a water bath at 50°C, and obtain the etoposide pre-emulsion concentrate.

Embodiment 3

[0105] Linoleic acid macrogol glycerides 1g a-tocopheryl palmitate 3.6g

[0106] Etoposide 0.5g Macrogol 400 4.8g

[0107] Citric acid 0.1g

[0108] Weigh linoleic acid macrogol glyceride, polyethylene glycol 400, α-tocopherol palmitate and citric acid, mix well, add etoposide, stir and dissolve in a water bath at 40°C to obtain etoposide pre-emulsified Concentrate.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a pharmaceutical composition and a preparation method thereof. Based on a large amount of experimental screening, a prescription composition of a etoposide self (micro) emulsification system (ie, pre-emulsification concentrate) is found, wherein the concentrate is clear, transparent, and unlayered, and has the characteristics of high drug content, low adjuvant toxicity, low adjuvant amount, high emulsification speed, and uniform particle size. The preparation method of the invention provides a better curative effect of etoposide, improves the solubility of etoposide, increases the bioavailability, and improves the stability of etoposide; based on the advantages of high efficiency and low toxicity of the new formulation, the antitumor activity of etoposide is fullyexerted and the toxic and side effects are reduced, which can undoubtedly promote the clinical applications of etoposide.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to etoposide and a preparation method thereof. Background technique [0002] Etoposide is a mitosis inhibitor and is now one of the most commonly used antineoplastic drugs in the world. The molecular weight of etoposide is 588, and it is extremely difficult to dissolve in water, normal saline and other physiological solutions. Unopened ampoules of etopodophylloside for intravenous injection are stable at room temperature for 24 months, and have the same stability in normal saline or dextran solution. The aqueous solution of etoposide has poor chemical stability and is easily affected by pH. In the solution of pH 1.3 and 10, etoposide degrades rapidly, and the degradation half-life is 2.88 and 3.83h respectively; 63 days and 49.5 days. Except for etoposide in oral soft capsules, inactive ingredients include: citrate, Tween 80, polyvinyl alcohol 400,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/107A61P35/00
Inventor 蔡勤
Owner SICHUAN KELUN PHARMA RES INST CO LTD