Method for preparing artificial bone with three-dimensional bone-like structure and product prepared by method

A three-dimensional structure and three-dimensional technology, applied in the field of artificial bone, can solve problems such as low biological activity, lack of support, and poor strength

Active Publication Date: 2011-06-29
北京惠方医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to overcome the problems of low bioactivity, poor strength and lack of support in the initial stage of implantation in existing bone-like materials, and to provide a three-dimensional bone-like structure with high bioactivity and high strength artificial bone

Method used

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  • Method for preparing artificial bone with three-dimensional bone-like structure and product prepared by method
  • Method for preparing artificial bone with three-dimensional bone-like structure and product prepared by method
  • Method for preparing artificial bone with three-dimensional bone-like structure and product prepared by method

Examples

Experimental program
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Effect test

Embodiment 1

[0023] (1) Add 30vol% HA hydroxyapatite, 0.3 gram of sodium lauryl sulfate and 0.3 gram of lauryl alcohol per 100 ml of deionized water, and stir evenly to obtain a ceramic mixed slurry; The 5wt% sodium alginate of 8vol% of the total volume of the mixture is used as the curing agent, and then the 3M CaCl that accounts for 8vol% of the total volume of the mixture is added 2 As an initiator, a green body of a three-dimensional bone-like structure is made by using a three-dimensional stacked assembly method;

[0024] The specific preparation process of the stent material green body is as follows:

[0025] In order to reproduce the complex external contour and internal aperture of the three-dimensional structure of natural bone, the three-dimensional gel laminate molding system disclosed in the authorized announcement CN 98124402.5C (Patent No. ZL 98124402.5) is automatically formed to obtain the blank of the scaffold material, and the internal The pore size can be produced by fo...

Embodiment 2

[0047] (1) Add 30vol% hydroxyapatite, 0.1 gram of sodium lauryl sulfate and 0.5 gram of lauryl alcohol per 100 ml of deionized water, and stir evenly to obtain a ceramic mixed slurry; then add the mixture to the above ceramic mixed slurry The 5wt% sodium alginate of total volume 5vol% is used as curing agent, then adds the 3M CaCl that accounts for 5vol% of total mixture volume 2 As an initiator, a green body of a three-dimensional bone-like structure is made by using a three-dimensional stacked assembly method;

[0048] The specific preparation process of the stent material green body is shown in Example 1.

[0049] (2) Step (1) is made into a three-dimensional bone-like structure green body, dried at 37°C for 48 hours, and then sintered at 900°C for 6 hours to obtain a HA three-dimensional structure scaffold with a pore size of 300-600 μm; made into a 10mm x 10mm 10 x 2mm samples, 5 of which are used to test the compressive strength, and 5 are used to test the activity of a...

Embodiment 3

[0056] (1) Add 30vol% hydroxyapatite, 0.5 gram of sodium lauryl sulfate and 0.1 gram of lauryl alcohol per 100 ml of deionized water, and stir evenly to obtain a ceramic mixed slurry; then add the mixture to the above ceramic mixed slurry The 5wt% sodium alginate of total volume 10vol% is used as curing agent, then adds the 3M CaCl that accounts for the total volume of mixture 10vol% 2 As an initiator, a green body of a three-dimensional bone-like structure is made by using a three-dimensional stacked assembly method;

[0057] The specific preparation process of the stent material green body is shown in Example 1.

[0058] (2) Step (1) is made into a three-dimensional bone-like structure green body, dried at 37°C for 48 hours, and then sintered at 1000°C for 5 hours to obtain a HA three-dimensional structure scaffold with a pore size of 300-600 μm; made into a 10mm x 10mm 10 x 2mm samples, 5 of which are used to test the compressive strength, and 5 are used to test the activi...

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Abstract

The invention discloses a method for preparing an artificial bone with a three-dimensional bone-like structure and a product prepared by the method. The method comprises the following steps of: preparing a green body with a three-dimensional bone-like structure by a three-dimensional laminated assembly molding process; drying and sintering the green body to obtain a high-strength hydroxyapatite (HA) scaffold with a three-dimensional structure or a high-strength beta-tricalcium phosphate (TCP) scaffold with a three-dimensional structure; and then compounding the high-strength HA scaffold or the high-strength beta-TCP scaffold with imitation bone solution with high bioactivity to obtain a HA or beta-TCP scaffold with a three-dimensional structure which has high bioactivity and high strength, wherein the HA or beta-TCP scaffold has high bioactivity, the compressive strength is more than 5Mpa, the porosity is 70 to 75 percent, and the aperture is 100 to 600mu m. The artificial bone with the three-dimensional bone-like structure which has high bioactivity and high strength can repair various bone defects and induce the bone defects into bones.

Description

technical field [0001] The invention relates to an artificial bone and a preparation method thereof, in particular to a preparation method of a three-dimensional bone-like structure artificial bone with high biological activity and a product prepared by the method, belonging to the field of artificial bones. Background technique [0002] At present, there are many patents on artificial bone and its preparation methods, including not only HA, β-TCP materials but also a large number of composite materials. Patents for HA or Nano-HA combined with collagen, such as US 7229971, US20170255422, US 200220018797, and JP 2003073304, etc., although they have bone fusion ability, their initial strength is poor and they cannot play a supporting role. They are useful for repairing some bone defects. difficulty. Contents of the invention [0003] The technical problem to be solved by the present invention is to overcome the problems of low bioactivity, poor strength and lack of support ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/50A61F2/28
Inventor 温宁田杰谟
Owner 北京惠方医疗科技有限公司
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