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Method for simultaneously detecting main component contents of quinapril hydrochloride and hydrochlorothiazide composition

A technology of quinapril hydrochloride and hydrochlorothiazide, which is applied in the direction of measuring devices, material separation, and analysis of materials, can solve problems such as difficulties and large polarity differences, and achieve the effects of simple operation, high precision, and good reproducibility

Active Publication Date: 2011-06-29
YANGZIJIANG PHARMA GROUP SHANGHAI HAINI PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the large difference in polarity between the two, it is difficult to simultaneously determine the content by isogradient elution

Method used

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  • Method for simultaneously detecting main component contents of quinapril hydrochloride and hydrochlorothiazide composition
  • Method for simultaneously detecting main component contents of quinapril hydrochloride and hydrochlorothiazide composition
  • Method for simultaneously detecting main component contents of quinapril hydrochloride and hydrochlorothiazide composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Chromatographic conditions: column Ultimate TM XB-CN (5μm, 4.6×250mm); column temperature: 40°C; mobile phase is acetonitrile: 0.05mol / L potassium dihydrogen phosphate solution (adjust pH 2.5 with phosphoric acid), 35:65; flow rate: 1ml / min ; Detection wavelength: 215nm; Injection volume: 20μl.

[0023] Under these chromatographic conditions, the peak eluting time of quinapril hydrochloride is 7.5 minutes, the peak eluting time of hydrochlorothiazide is 4.5 min, and the column efficiency is not less than 1000 based on the peak of quinapril hydrochloride.

[0024] Preparation of reference substance solution: Accurately weigh quinapril hydrochloride reference substance (approximately equivalent to 10 mg of quinapril), and appropriate amount of hydrochlorothiazide reference substance after drying at 105°C for 1 hour (corresponding to the prescription amount of hydrochlorothiazide for 10 mg of quinapril) , dissolved in mobile phase, diluted to make a solution containing ab...

Embodiment 2

[0030] Chromatographic conditions: chromatographic column ZORBAX XDB-C8 (5μm, 4.6×250mm); column temperature: 30°C; mobile phase is acetonitrile: 0.05mol / L potassium dihydrogen phosphate solution (adjust pH 3.0 with phosphoric acid), 40:60 ; Flow rate: 1ml / min Detection wavelength: 215nm; Injection volume: 20μl.

[0031] Under these chromatographic conditions, the peak eluting time of quinapril hydrochloride is 7.0 min, the peak eluting time of hydrochlorothiazide is 4.0 min, and the column efficiency is better than 1000 in terms of quinapril hydrochloride peak.

[0032] Preparation of reference substance solution: Accurately weigh quinapril hydrochloride reference substance (approximately equivalent to 10 mg of quinapril), and appropriate amount of hydrochlorothiazide reference substance after drying at 105°C for 1 hour (corresponding to the prescription amount of hydrochlorothiazide for 10 mg of quinapril) , dissolved in mobile phase, diluted to make a solution containing ab...

Embodiment 3

[0037] Chromatographic conditions: column Ultimate TM XB-CN (5μm, 4.6×250mm); Column temperature: 40°C; Mobile phase is acetonitrile: 0.05mol / L potassium dihydrogen phosphate solution (adjust pH3.5 with phosphoric acid), 35:65; Flow rate: 1.2ml / min; detection wavelength: 215nm; injection volume: 20μl.

[0038] Under these chromatographic conditions, the peak elution time of quinapril hydrochloride is about 7.5 minutes, and the peak elution time of hydrochlorothiazide is about 4.5 minutes, and the column efficiency is not less than 1000 based on the peak of quinapril hydrochloride.

[0039] Preparation of reference substance solution: Accurately weigh quinapril hydrochloride reference substance (approximately equivalent to 10 mg of quinapril), and appropriate amount of hydrochlorothiazide reference substance after drying at 105°C for 1 hour (corresponding to the prescription amount of hydrochlorothiazide for 10 mg of quinapril) , dissolved in mobile phase, diluted to make a s...

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Abstract

The invention provides a method for simultaneously detecting the main component contents of a quinapril hydrochloride and hydrochlorothiazide composition. The method adopts the high-efficiency liquid chromatography to simultaneously measure the contents of quinapril hydrochloride and hydrochlorothiazide at one time. The method comprises the following steps: adopting the high-efficiency liquid chromatography, using a cyano chromatographic column or a C8 chromatographic column, adopting a mobile phase composed of an organic phase and a water phase for isocratic elution, and introducing a sample at one time. Therefore, the detection effects of high precision and repeatability can be achieved. The method is simple, is easy and quick to operate, is stable and reliable, and has higher application value.

Description

technical field [0001] The invention relates to a method for detecting medicines, in particular to a method capable of simultaneously detecting the contents of two main components, quinapril hydrochloride and hydrochlorothiazide, contained in the composition of the medicine for treating hypertension, quinapril hydrochloride and hydrochlorothiazide. Background technique [0002] Hypertension is a common cardiovascular and cerebrovascular disease. There are 110 million hypertensive patients in China. With the improvement of living standards, changes in diet structure and increased work pressure, hypertensive patients are increasing by 350 per year. development at the speed of thousands of people. Clinically, cases of disability and death due to hypertension are not uncommon. In China alone, approximately 1.2 million people die each year due to hypertension. [0003] At present, the drugs for the treatment of hypertension are mainly divided into: 1. diuretics; 2. beta-receptor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/36
Inventor 郭晓静唐开勇谢雨礼安日明张静平
Owner YANGZIJIANG PHARMA GROUP SHANGHAI HAINI PHARMA
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