Compound valeriana amurensis composition for treating senile dementia, and preparation method and application thereof

Abstract

The invention relates to a compound valeriana amurensis composition for treating senile dementia, and a preparation method and application thereof. The composition can be used for treating neurodegenerative diseases such as the senile dementia and the like. The preparation method comprises the following steps of: crushing valeriana amurensis into coarse powder, collecting by a steam distillation method to obtain volatile oil, heating dregs of decoction for refluxing by using 75 percent ethanol to obtain ethanol extract, after dissolving the ethanol extract in water, extracting by using petroleum ether, concentrating aqueous layer extract liquor, adsorbing by using AB-8 macroporous resin, eluting by using water, 50 percent ethanol and 95 percent ethanol respectively, collecting eluent of 50 percent ethanol, concentrating, drying, and mixing with part of volatile oil uniformly to prepare an active ingredient extract of valeriana amurensis; heating polygalae for refluxing by using 85 percent ethanol and extracting to obtain ethanol extract, mixing and suspending the ethanol extract in the water, adsorbing by using D101 macroporous resin, eluting by using the water, 50 percent ethanol and 95 percent ethanol respectively, collecting eluent of 50 percent ethanol, concentrating and drying to prepare an active ingredient extract of polygalae; and mixing the active ingredient extract of the valeriana amurensis and the active ingredient extract of the polygalae according to a ratio to prepare various oral administration preparations such as capsules, tablets, granules, pills or oral liquid and the like.

Description

technical field [0001] The invention relates to a composition, in particular to a traditional Chinese medicine composition for treating senile dementia. The composition is composed of an active ingredient extract of Valerian officinalis and an active ingredient extract of Polygala, which can be used for treating senile dementia. Background technique [0002] Senile dementia, also known as Alzheimer's disease, is a common clinical disease and a heterogeneous disease with a variety of pathogenesis, with characteristic neuropathological and neurochemical changes. There are obstacles in judgment, spatial recognition, emotion, etc. With the aggravation of the disease, the symptoms deteriorate from initial amnesia, cognitive impairment, and calculation ability impairment to aphasia, thinking and emotional disorders, and even muscle rigidity, incontinence, and inability to take care of themselves . It not only brings great pain to patients physically and mentally, but also creates...

AI Technical Summary

Problems solved by technology

It not only brings great pain to the patient physically and mentally, but also creates a lot of pressure and burden on the family and society.

There are many drugs used to treat senile dementia, mainly divided into cholinergic drugs, drugs that interfere with the formation and deposition of Aβ, estrogen drugs, and drugs that promote brain metabolism. Most of the traditional Chinese medicine preparations used in clinical practice have many flavors, insignificant curative effect, rough preparations, difficult to control quality, and high side effects. Poor stability, etc., so that it cannot be used clinically for a long time, and pure Chinese medicine preparations with definite curative effect and less toxic side effects in the treatment of senile dementia in the true sense are still in a relative shortage

Both black water valerian and polygala come from traditional Chinese medicine, both of which have the effects of invigorating the mind, invigorating the spleen, and calming the nerves. The combination of the two can play a synergistic effect, and can comprehensively improve various indications of senile dementia in multiple ways and links. The active ingredients of the two Compositions for the treatment of senile dementia have not yet been reported

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