Rhubarb anthraquinones component extracting and separating method

A separation method, technology of rhubarb anthraquinone, applied in medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, organic active ingredients, etc., can solve problems that are difficult to adapt to large-scale production and growing market needs, Restricting product export, failing to achieve high purity and other issues, achieving the effect of saving extraction time and solvent consumption, stable product quality, and improving purity

Active Publication Date: 2013-01-02
南通东湖国际商务服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the extraction rate of these processes is very low, and the purity is not high, which is far from meeting the high-purity requirements of the domestic and international markets. This has a great impact on the export of Chinese medicine extracts in my country, making my country in the export trade of rhubarb anthraquinone extracts from beginning to end. are passive
Therefore, problems such as low efficiency and low purity have become the main obstacles restricting the export of this product at this stage. If things go on like this, it will be difficult to adapt to large-scale production and growing market needs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Extract and purify rhein from rhubarb:

[0021] Step (1) Put 50 g of rhubarb medicinal materials with a particle size of 20 mesh into a three-necked flask, add 1000 ml of an aqueous solution with a pH of 10, stir with air bubbling, and treat in a microwave device at 50±10°C for 80 seconds, cool down, and filter with suction , to obtain the extract.

[0022] The output power of the microwave oven is 650W, and the frequency is 2450MHz;

[0023] Step (2) adjust the pH of the product obtained in step (1) to 4 with hydrochloric acid.

[0024] Step (3) The product obtained in step (2) is continuously adsorbed and separated through the XDA-1 type macroporous resin chromatography column, so that the target component remains in the resin column;

[0025] The flow rate of the product obtained in step (2) in the macroporous resin chromatography column is 4BV / h;

[0026] The volume consumption of the product that step (2) obtains is 25 times of described macroporous resin weight...

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Abstract

The invention relates to a rhubarb anthraquinones component extracting and separating method which is characterized by comprising the following steps of putting raw materials containing rhubarb anthraquinone into a microwave extracting device, and adding a basic solvent, extracting microwaves; collecting and filtering an extracting solution, adjusting the pH value of the extracting solution to bein acidity, sampling through a macroporous adsorbent resin column, and decompressing, recovering and concentrating ethanol; adding a concentrated solution to a chromatographic column filled with activated carbon, eluting the chromatographic column with water; and collecting an eluent, concentrating the eluent with a reverse osmosis membrane and drying the eluent to obtain the rhubarb anthraquinones component. By adopting the method, the production cost can be reduced, and the product quality can be enhanced. The method is convenient for industrialization operation.

Description

technical field [0001] The invention relates to a method for extracting and separating anthraquinone components of rhubarb, in particular to a method for separating anthraquinone components by utilizing microwave alkaline solvent extraction and macroporous resin. technical background [0002] Rhubarb anthraquinones widely exist in Rheum palmatum (R. palmatum L.), Tanguticum rhubarb (R. tanguticum. Maxim. ex Regel) and medicinal rhubarb (R. Officinal.Baill) roots and foundations, studies have found that such active substances have a wide range of pharmacological activities, such as anti-tumor, anti-inflammatory, antibacterial and kidney function regulation. [0003] There are many anthraquinones in rhubarb, such as emodin, aloe-emodin, chrysophanol and emodin methyl ether. Therefore, the main extraction, purification and separation of anthraquinones is relatively difficult, and the price remains high. Regarding the extraction and separation of rhubarb anthraquinones, the mos...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61K36/708A61P35/00A61P29/00A61P31/04A61P13/12A61K125/00
Inventor 栗进才黄鹏汪电雷周光姣夏成凯
Owner 南通东湖国际商务服务有限公司
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