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Nanometer pore hydroxyl calcium phosphate/aquogel materials

A technology of calcium hydroxyphosphate and hydrogel, which is applied in the field of biomedicine and can solve problems such as ignoring the role of water-soluble proteins

Active Publication Date: 2011-09-21
CHANGZHOU KANGWEI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional theoretical concepts ignore the role of water-soluble proteins

Method used

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  • Nanometer pore hydroxyl calcium phosphate/aquogel materials
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  • Nanometer pore hydroxyl calcium phosphate/aquogel materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] The preparation method of the nanoporous calcium hydroxyphosphate / hydrogel material provided by the invention comprises the following steps:

[0073] (1) preparation mass concentration is the hydrogel aqueous solution of 1%, preparation mass concentration is the glutaraldehyde aqueous solution of 3%, preparation concentration is the polypeptide aqueous solution of 10ug / mL,

[0074] The hydrogel is collagen; the polypeptide is osteopontin (OPN) contained in bones; the hydrogel material is added with a mass percentage of 0.0001% of a small molecular compound that promotes the proliferation of osteoblasts.

[0075] (2) Preparation of hydrogel substrate: the three aqueous solutions prepared in step (1) were mixed according to the volume ratio of 1:1:1, stirred at room temperature for 0.5 minutes, and then the mixture was placed on the carrier, The hydrogel substrate was prepared by phase separation technique, and the prepared hydrogel substrate was soaked with 0.1M glycine ...

Embodiment 2

[0080] The preparation method of the nanoporous calcium hydroxyphosphate / hydrogel material provided by the invention comprises the following steps:

[0081] (1) preparation mass concentration is the hydrogel aqueous solution of 5%, preparation mass concentration is the glutaraldehyde aqueous solution of 8%, preparation concentration is the polypeptide aqueous solution of 300ug / mL,

[0082] The above-mentioned hydrogel is gelatin; the above-mentioned polypeptide is phosphophoryn or its fragments contained in teeth; the above-mentioned hydrogel material is added with a mass percentage of 5% small molecular compound that promotes the proliferation of osteoblasts.

[0083] (2) Preparation of hydrogel substrate: the three aqueous solutions prepared in step (1) were mixed according to the volume ratio of 1:1:1, stirred at room temperature for 10 minutes, and then the mixture was placed on the carrier, The hydrogel substrate was prepared by phase separation technique, and the prepare...

Embodiment 3

[0088] The preparation method of the nanoporous calcium hydroxyphosphate / hydrogel material provided by the invention comprises the following steps:

[0089] (1) preparation mass concentration is the hydrogel aqueous solution of 3%, preparation mass concentration is the glutaraldehyde aqueous solution of 6%, preparation concentration is the polypeptide aqueous solution of 150ug / mL,

[0090] The above-mentioned hydrogel is a composition of collagen and gelatin, and the weight ratio of collagen and gelatin is 1:3; the above-mentioned polypeptide is a polypeptide rich in aspartic acid, wherein the sum of the aspartic acid accounts for the weight of the polypeptide The percentage is 10%; the hydrogel material is added with a mass percentage of 2.5% of a small molecular compound that promotes the proliferation of osteoblasts.

[0091] (2) Preparation of hydrogel substrate: the three aqueous solutions prepared in step (1) were mixed according to the volume ratio of 1:1:1, stirred at ...

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Abstract

The invention belongs to the field of biological medicines, and particularly relates to hydroxyl calcium phosphate / aquogel materials which are used as repair and implanting materials for bones or teeth. In order to solve the problems that high bonding interfaces are not formed between tooth implants and dental bones and the like during tooth or bone repair in the prior art, the invention providesnanometer pore hydroxyl calcium phosphate / aquogel materials, which are characterized in that an aquogel surface is modified by polypeptides, and hydroxyl calcium phosphate is deposited on aquogel by the bionic mineralization process. The nanometer pore hydroxyl calcium phosphate / aquogel materials are materials which are highly close to or consistent with materials of human bodies in aspects of macroscopic forms and microstructures and are used for orthopedics and dentistry, are high in biocompatibility, and can be used as repair materials, filling materials and biological support materials for the teeth or the bones.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a calcium hydroxyphosphate / hydrogel material used as bone or tooth repair and implant material. Background technique [0002] According to relevant statistics, the incidence rate of dental caries in the population of our country is 37%, with an average of 2.47 dental caries per person. There is a great demand for filling materials for repairing dental caries, and the estimated annual demand is about 1 ton. However, none of the currently used dental filling materials can promote rapid restoration of tooth tissue. [0003] For lost carious teeth, an artificial tooth root is usually installed. Artificial tooth root, also known as dental implant, is a device that is surgically implanted into the jawbone of the missing tooth of the human body and repaired on its upper part after healing. Dental implants can be roughly divided into five types according to their materials, namel...

Claims

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Application Information

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IPC IPC(8): A61L27/52A61L27/32A61L27/22A23L1/29A61K6/033A23L33/00A61K6/838
Inventor 戴立军
Owner CHANGZHOU KANGWEI BIOTECH
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