4-(4-(3-trifluoro methyl) benzamido phenoxyl)-2-(methyl carbamyl) pyridine salt, its preparation method and application

A technology of benzamidophenoxy and methylcarbamoyl, applied in the field of chemical medicine, can solve the problems of low solubility, hinder the timely absorption of drugs, and low absolute bioavailability of oral administration, and achieve high solubility and bioavailability. high effect
CN102199121AInactive Publication Date: 2011-09-28SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SICHUAN UNIV
Publication Date
2011-09-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to 4-(4-(3-trifluoro methyl) benzamido phenoxyl)-2-(methyl carbamyl) pyridine salt, its preparation method and an application, which belongs to the chemical medicine field. The structure of 4-(4-(3-trifluoro methyl) benzamido phenoxyl)-2-(methyl carbamyl) pyridine salt is shown as a formula I, X can be one of hydrochloric acid, acetic acid, benzoic acid, benzene sulfonic acid, citric acid, fumaric acid, glucurnic acid, malic acid, maleate, C1-C8 alkyl substituted sulfonic acid, naphthoic acid, nitric acid, oleic acid, oxalic acid, phosphoric acid, succinic acid, tartrate, sulfuric acid, C1-C8 alkyl substituted benzene sulfonic acid, ethanolamine, trifluoroacetic acid, lactic acid, dinaphthyl salicylic acid or asccharin. 4-(4-(3-trifluoro methyl) benzamido phenoxyl)-2-(methyl carbamyl) pyridine salt of the present invention has the advantages of high solubility and high bioavailability, which can be used for preparing medicines to treat cancer.
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Description

technical field

[0001] The invention relates to 4-(4-(3-trifluoromethyl)benzamidophenoxy)-2-(methylcarbamoyl)pyridinium salt and its preparation method and application, belonging to the field of chemical medicine. Background technique

[0002] Malignant tumors have become the second leading cause of human death, seriously threatening human health. In my country, according to the latest statistics, tumors have become the number one cause of death for our people. According to the latest epidemiological survey data, there are more than 3 million cancer patients in my country, and about 1.3 million patients die of malignant tumors every year. Every year, there are 1.6 to 2 million new cases of malignant tumors, and they are increasing at a rate of 3%, which poses a huge threat to the life and health of our people and brings huge pressure to society and families. To a certain extent, it restricts the sustainable economic development of our country. Traditional tumor treatment met...

Claims

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