Method for purifying and recycling feed liquid from erythromycin produced by fermentation method

A technology of erythromycin and fermentation method is applied in the field of purifying and recycling fermentation method to produce erythromycin feed liquid, which can solve the problems of environmental protection, resource waste, waste and the like that are not fundamentally solved, and achieves convenient operation and resource saving. , the effect of low operating cost

Active Publication Date: 2013-09-11
四川金本科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For decades, the industry has not used this type of wastewater as a resource, and the huge waste is shocking
However, all the previous research work on the feed solution focused on the oxidation of wastewater and the adjustment of pH value, which did not fundamentally solve the environmental protection problem and caused a huge waste of resources.

Method used

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  • Method for purifying and recycling feed liquid from erythromycin produced by fermentation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 A method for purifying and recycling erythromycin feed liquid by fermentation, characterized in that: XDA-1 resin is used to absorb α-erythromycin in the feed liquid, and acetone is added to analytically pure acetone After the eluent eluting described resin of volume 15% distilled water preparation, the pH value of adjusting eluent is 8 and the water content of adjusting eluent is 18%wt, then adjusts the pH value of eluent to 9.5, will The eluate was heated to 45°C and kept for 3 hours to precipitate and crystallize erythromycin. Finally, it was washed with 50°C distilled water and centrifuged, and the solid obtained by centrifugation was dried in a vacuum dryer at 50°C to obtain erythromycin Prime alkali.

[0018] In view of the purity and hygienic requirements of the product, the extraction wastewater from the production of erythromycin by fermentation is transported from the extraction process (extraction tank) of the pharmaceutical factory to the feed li...

Embodiment 2

[0019] Example 2 A method for purifying and recycling erythromycin feed liquid by fermentation, characterized in that: D-4020 resin is used to absorb α-erythromycin in the feed liquid, and acetone is added to analytically pure acetone After the eluent eluting described resin of volume 10% distilled water preparation, adjust the pH value of eluent at 7 and adjust the water content of eluent at 15%wt, then adjust the pH value of eluent to 9, will The eluate is heated to 50°C and kept for 2 hours to precipitate and crystallize erythromycin, and finally to perform secondary washing and centrifugation with 50°C distilled water, and dry the solid obtained by centrifugation at no higher than 50°C to obtain erythromycin alkali.

[0020] In view of the purity and hygienic requirements of the product, the extraction wastewater from the production of erythromycin by fermentation is transported from the extraction process (extraction tank) of the pharmaceutical factory to the feed liqui...

Embodiment 3

[0021] Example 3 A method for purifying and recycling erythromycin feed liquid by fermentation, characterized in that: D-1300 resin is used to absorb α-erythromycin in the feed liquid, and acetone is added to analytically pure acetone After the eluent eluting described resin of volume 20% distilled water preparation, adjust the pH value of eluent at 10 and adjust the water content of eluent at 20%wt, then adjust the pH value of eluent to 10.5, will The eluate is heated to 40°C and kept for 4 hours to precipitate and crystallize erythromycin. Finally, it is washed with 50°C distilled water and centrifuged, and the solid obtained by centrifugation is dried in a vacuum dryer at no higher than 50°C to obtain Erythromycin base.

[0022] In view of the purity and hygienic requirements of the product, the extraction wastewater from the production of erythromycin by fermentation is transported from the extraction process (extraction tank) of the pharmaceutical factory to the feed li...

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Abstract

The invention belongs to the field of purifying and recycling pharmaceutical wastewater and specifically relates to a method for purifying and recycling a feed liquid from erythromycin produced by the fermentation method. The method provided by the invention is characterized by adsorbing Alpha-erythromycin in the feed liquid by using multistage resin; eluting the resin by using an eluant; adjusting the eluate with its pH value being from 7 to 10 and its water content being less than or equal to 20 wt%; precipitating and crystallizing erythromycin by using a precipitating agent or the hydrolysis control method, followed by cleaning and centrifugation; and drying the solid substance produced by the centrifugation step at a low temperature to obtain erythromycin. The method provided by the invention has advantages of low operation cost, convenient operation, reliable and flexible technology control, accomplishes the purpose of effectively obtaining the target substance by the solid phase extraction (adsorption) principle, effectively separates drug residuals in pharmaceutical factory wastewater from other contained substances to highly purify the wastewater, wherein the erythromycin content is lower than 1ppm and superior to national wastewater discharge standards, is friendly to environment, and produces no second pollution.

Description

technical field [0001] The invention belongs to the field of purification and recycling of pharmaceutical waste water, and in particular relates to a method for purifying and recycling a fermentation method for producing erythromycin feed liquid. Background technique [0002] In the process of producing erythromycin API by fermentation, the extraction of fermentation feed liquid is an essential process, and the remaining fresh feed liquid (waste water) in this process contains erythromycin with a residual amount of about 0.1~0.3%wt Elements, amino acids with a comprehensive content of up to 1~3%wt, and solvents (butyl acetate) with a solubility saturation level of 0.7%wt. In the industry that produces erythromycin raw materials by fermentation, based on the annual production of 3 million tons of such wastewater, the loss of solvent (butyl acetate) is nearly 20,000 tons, and the annual loss of amino acids is as high as 100,000 tons. For decades, the industry has not used thi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/08C07H1/06C02F1/28C02F1/58
Inventor 韩志范高继轩王利娅杨舒涵
Owner 四川金本科技有限公司
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