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Vitexin glucoside injection and preparation method thereof

A technology of vitexin glucoside and glucoside injection, which is applied in the fields of medical formula, medical preparations containing active ingredients, drug delivery, etc., and can solve the problems of low bioavailability, difficult control of product quality, and slow onset of hawthorn leaf preparations and other issues, to achieve the effect of high bioavailability, easy industrial production and application, and fast onset of action

Inactive Publication Date: 2011-11-02
HEBEI SHINEWAY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problems of slow onset of action, low bioavailability, and difficult control of product quality in the existing hawthorn leaf preparation, thereby providing a kind of vitexin glucoside injection for clinical use, and simultaneously providing a kind of the preparation preparation method

Method used

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  • Vitexin glucoside injection and preparation method thereof
  • Vitexin glucoside injection and preparation method thereof
  • Vitexin glucoside injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 10 grams of vitexin glucoside, 0.5 grams of sodium bisulfite, add 8 liters of water for injection to dissolve, adjust the pH to 6.5 with 10% sodium hydroxide solution, add 8 grams of activated carbon, stir well, decarbonize and filter, and filter the filtrate. 0.22 micron filter membrane, add water for injection to 10 liters, potting, and sterilize in a water bath at 100°C for 30 minutes to obtain 1000 vials of vitexin glucoside injection with a specification of 10ml: 10mg.

Embodiment 2

[0016] Take 50 grams of vitexin glucoside, 2.5 grams of sodium bisulfite, add 8 liters of water for injection to dissolve, adjust the pH to 6.5 with 10% sodium hydroxide solution, add 8 grams of activated carbon, stir well, decarbonize and filter, and filter the filtrate. 0.22 micron filter membrane, add water for injection to 10 liters, potting, and sterilize in a water bath at 100°C for 30 minutes to obtain 1000 vials of vitexin glucoside injection with a specification of 10ml: 50mg.

Embodiment 3

[0018] Take 50 grams of vitexin glucoside, 2.5 grams of sodium pyrosulfite, add 8 liters of water for injection to dissolve, adjust the pH to 6.5 with 10% sodium hydroxide solution, add 8 grams of activated carbon, stir well, decarbonize and filter, and the filtrate passes through 0.22 microns add water for injection to 10 liters, potting, and sterilize in a water bath at 100°C for 30 minutes to obtain 1000 vials of vitexin glucoside injection with a specification of 10ml: 50mg.

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Abstract

The invention discloses a vitexin glucoside injection and a preparation method thereof. The injection employs vitexin glucoside as an active ingredient and water for injection as a solvent, wherein the effective dose of the active ingredient is 1-10 mg vitexin glucoside per 1 ml injection. The preparation method comprises the following steps of: weighing the vitexin glucoside and antioxidant according to the prescription quantities thereof, and adding the water for injection, which accounts for 80% of the prescription quantity, to the mixture of the vitexin glucoside and the antioxidant so that the mixture is dissolved; regulating the pH to a range of 5.5 to 7.5 by using 10% of sodium hydroxide solution; next, adding 0.1% of active carbon to the solution obtained in the previous step, stirring the solution evenly, decarbonizing and filtering the solution, leading the filtrate to flow through a filter membrane of 0.22 microns; adding the water for injection to the full quantity, and then performing filling and sealing; and finally, sterilizing the product in a water bath at 100 DEG C for 30 minutes. The vitexin glucoside injection solves the problems of taking effect slowly, low bioavailability and great difficulty in control of product quality in the existing hawthorn leaf preparation, and provides a new medicine for treating ischemic heart diseases for clinical therapy.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to a pharmaceutical preparation for treating ischemic heart disease and a preparation method thereof. Background technique [0002] Cardiovascular disease is one of the most serious diseases that threaten human beings in the world today. Its morbidity and mortality have surpassed tumor diseases and ranked first in the world. The World Health Organization's 2004 Global Burden of Disease report pointed out that in 2004, there were 1700 people in the world. Ten thousand people die from cardiovascular disease, and by 2030, the number of deaths is expected to exceed 23 million. In recent years, with the gradual improvement of people's living standards in our country, the acceleration of population aging, the accelerated pace of life, and the development of eating habits towards high fever and hyperlipidemia, coronary heart disease, hypertension, hyperlipide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7048A61P9/10
Inventor 张纲姜海
Owner HEBEI SHINEWAY PHARMA
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