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Improved intravenously dripped multi-vitamin injection

An intravenous infusion and vitamin technology, applied in the field of medicine, can solve the problems of different ingredients, reduce patient tolerance and compliance, and limit clinical application

Inactive Publication Date: 2011-11-16
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Another 13 kinds of vitamin powder for injection has been launched in Japan. This drug has the same indications as the 13 kinds of vitamin injections listed in the United States, but the ingredients are different. The dosage of vitamin D2 and vitamin K is appropriately increased, and the adjustment The content of other vitamins makes its effect more comprehensive and effective, but this powder injection needs to be mixed and dissolved with high-calorie parenteral nutrients, adjusted to isotonicity and isotonicity, and administered through central vein drip, which greatly limits It improves its clinical application and reduces the patient's tolerance and compliance

Method used

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  • Improved intravenously dripped multi-vitamin injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1 13 kinds of compound vitamin freeze-dried powders

[0008]

[0009]

[0010] Preparation:

[0011] 1. Dissolving fat-soluble vitamins

[0012] 1) Take the prescribed amount of Tween-80, heat it in a water bath to 50°C and keep stirring, put carbon dioxide on top of the Tween-80, turn vitamin A (palmitate), vitamin E, vitamin K, vitamin D2, and heat in a water bath Stir at 50°C to dissolve completely, keep stirring and keep warm.

[0013] 2) Take 500ml of water for injection at the same temperature, and inject carbon dioxide gas from the bottom to keep the temperature. After 5 minutes, slowly add it to the Tween liquid, and keep stirring until a clear solution is obtained.

[0014] 2. Take 2000ml of freshly prepared water for injection, and inject carbon dioxide from the bottom for 30 minutes. Add the prescribed amount of vitamin C, adjust the pH value to 4.3 with 2M NaOH, add the prescribed amount of vitamin B2, niacinamide, dexpanthenol, TPP, and ...

Embodiment 2

[0022] Comparative experiment of drug efficacy and adverse reactions of different routes of administration

[0023] 24 healthy adult rabbits, half male and half male, weighing (2.45±0.40) kg. They were randomly divided into two groups: Group A was sham operation group (6 rats), and Group B was total gastrectomy group (18 rats). Inject (intravenously) 20% urethane 5ml / kg through ear vein, finish the injection within 15min, and fix the animal after successful anesthesia. After opening the abdominal cavity of the rabbits in group A, the internal organs were covered with saline gauze, and the abdominal cavity was closed after 1 hour. Rabbits in group B underwent total gastrectomy (the resection range was from the cardia to about 0.5 cm proximal to the pylorus), and then the esophagus was pulled down and anastomosed end-to-side with the proximal duodenum. The postoperative rabbits in group B were randomly divided into 3 groups, with 6 rabbits in each group. Group B1 was the model...

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Abstract

The invention relates to an improved intravenously dripped multi-vitamin injection. The injection can be mixed with high-calorie parenteral nutrients to be dissolved and adjusted to have isotonicity and isostension and then can be administrated through peripheral intravenous drip, wherein the intravenously dripping time is 6 to 12 hours; and dripping is performed at constant speed and for one time per day.

Description

technical field [0001] The invention relates to an improved multivitamin injection which can be infused intravenously, and belongs to the technical field of medicine. Background technique [0002] Nutrition is the material basis for the body to grow and develop, repair tissues, generate resistance, and maintain normal physiological functions. It is the source of normal growth and activities of organisms and an indispensable condition for patients to recover. When people are healthy, various nutrients are naturally maintained in balance. Malnutrition is often caused by insufficient nutrient intake or increased demand when the body is sick. Despite rapid medical advances in recent years, malnutrition among hospitalized patients remains a widespread problem worldwide. Domestic clinical epidemiological surveys show that 30%-70% of inpatients in our country are currently malnourished when they are admitted to the hospital or during their hospitalization. The incidence of malnu...

Claims

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Application Information

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IPC IPC(8): A61K31/714A61K31/592A61K31/375A61K31/07A61K31/51A61K9/19A61K31/525A61K31/4415A61K31/455A61K31/355A61K31/122A61K31/4188A61K31/519A61K31/164A61P3/02
Inventor 不公告发明人
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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