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Transition metal complex with papaverine oxide as a ligand, its synthesis method and application

A technology of transition metal and sea papaverine, applied in copper organic compounds, zinc organic compounds, iron organic compounds, etc., can solve the problems such as the blank of chemical research, and achieve the effect of strong antitumor activity and good medicinal value.

Inactive Publication Date: 2011-11-30
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the chemical research of transition metal complexes based on papaverine oxide is still blank

Method used

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  • Transition metal complex with papaverine oxide as a ligand, its synthesis method and application
  • Transition metal complex with papaverine oxide as a ligand, its synthesis method and application
  • Transition metal complex with papaverine oxide as a ligand, its synthesis method and application

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Experimental program
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Effect test

Embodiment 1

[0025] Embodiment 1: OGC-Mn is synthesized with high-pressure solvothermal method II Complex

[0026] Weigh 0.1mmol OGC and add it to a 25cm Pyrex thick-walled glass tube with one end closed, add 2.0mL CH 3 OH and 1.0 mL H 2 O, then weigh 0.1mmol of Mn(ClO 4 ) 2 ·6H 2 O was added to the glass tube, and after being frozen in liquid nitrogen, the open end was melted and sealed under vacuum conditions. After mixing evenly, it was placed in an oven at 110°C. After 12 hours, red blocky crystals were formed in the glass tube (yield: 56%). The product was determined to be the target complex [Mn(OGC) 2 (H 2 O) 2 ](ClO 4 ) 2 .

Embodiment 2

[0027] Embodiment 2: OGC-Fe is synthesized with normal pressure solution method II Complex

[0028] 1mmol Fe(ClO 4 ) 2 .6H 2 O was dissolved in 10 mL of water; 2 mmol of OGC was heated and dissolved in 40 mL of ethanol. The two solutions were mixed and reacted at 80°C (reflux) for 1 hour. After the reaction, the solvent was properly concentrated to obtain a red suspension. A large number of complex solids were formed; filtered, washed with water, ethanol, and ether in sequence, and finally dried in vacuum at room temperature 25°C to obtain a red powdery solid product (yield: 50%). The product was determined to be the target complex [Fe(OGC) 2 (H 2 O) 2 ](ClO 4 ) 2 .

Embodiment 3

[0029] Embodiment 3: OGC-Co is synthesized by high-pressure solvothermal method II Complex

[0030] Weigh 0.1mmol OGC and add it to a 25cm Pyrex thick-walled glass tube with one end closed, add 0.4mL CH 3 OH and 0.1 mL CHCl 3 , and then weighed 0.1mmol of Co(ClO 4 ) 2 ·6H 2 O was added to the glass tube, and after freezing with liquid nitrogen, the open end was melted and sealed under vacuum conditions. After mixing evenly, it was placed in an oven at 80°C. After 48 hours, dark red blocky crystals were formed in the glass tube (yield: 65%). The product was determined to be the target complex [Co(OGC) 2 (H 2 O) 2 ](ClO 4 ) 2 .

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Abstract

The invention discloses transition metal coordination compounds with oxoglaucine as a ligand. The structural formula of the coordination compounds is represented by a formula (I), wherein M represents a bivalent metal cation which is selected from transition metal elements in the fourth period of the elements periodic table; X represents an anion of a metal salt when the metal cation is subject to a reaction in a form of metal salt, and X is nitrate or perchlorate. The coordination compounds can be synthesized with a normal-pressure solution method or a high-pressure solvent heating method. According to the invention, the inhibition effects of the transition metal coordination compounds upon various tumor cell strains are detected. As a result, a plurality of transition metal coordinationcompounds show stronger anti-tumor activities than oxoglaucine ligand. Therefore, the transition metal coordination compounds have good potential medicinal value, and can be used in preparations of various anti-tumor medicines.

Description

technical field [0001] The present invention relates to a metal complex, in particular to a transition metal complex with sea papaverine oxide as a ligand, a synthesis method and an application thereof. Background technique [0002] Oxoglaucine (OGC) is a typical oxidized aporphine, which is widely found in traditional Chinese medicine plants such as Magnoliaceae, Anemonaceae, Papaveraceae, and Fangjiaceae. Oxidized aporphine alkaloids are a series of alkaloids with significant pharmacological activity. It is generally believed that the planar hyperdelocalized conjugated structure of most oxidized aporphine bases and the different substituent groups (such as methylenedioxy group (-O-CH 2 -O-), Methoxy (-OCH 3 )) has a significant relationship with its antitumor activity. The current research on papaverine mainly includes three aspects: one is to find and purify from plants of different families and genera as mentioned above (especially in medicinal plants) based on the ch...

Claims

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Application Information

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IPC IPC(8): C07F13/00C07F15/02C07F15/04C07F15/06C07F1/08C07F3/06A61K31/555A61P35/00
Inventor 梁宏陈振锋刘延成史艳芳
Owner GUANGXI NORMAL UNIV
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