Extraction method of effective components of Morinda officinalis leaves

A technology of Morinda citrifolia leaves and active ingredients, which is applied in the field of extraction of active ingredients of Morinda officinalis leaves, can solve problems such as patent reports of no extraction process, and achieve large-scale production operations, large sample volume, and high product purity Effect

Inactive Publication Date: 2011-12-07
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The research on the leaves of Morinda officinalis is still in

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Crush Morinda officinalis leaves, take 2kg, use 60% ethanol solution as solvent, carry out multi-tank dynamic countercurrent extraction, take 3 tanks as a cycle unit, extract 3 times in each tank, the second and third times in each tank The extract is used as the solvent for the first and second extractions of the next tank respectively. The first extract of each tank is put into the liquid storage tank, and the extract is obtained after filtration. The extract is concentrated by rotation, and water is added to a certain volume, filtered, and the filtrate is HPD -400 type macroporous resin, first eluted with 5BV water, then eluted with 5BV65% ethanol solution, collected the ethanol eluate, concentrated to a relative density of 1.05, spray-dried the supernatant, dried the precipitate under reduced pressure, and mixed evenly. 33 g of extract were obtained.

Embodiment 2

[0021] Grind Morinda officinalis leaves, take 2kg, use 65% ethanol solution as solvent, carry out multi-tank dynamic countercurrent extraction, take 3 tanks as a cycle unit, extract 3 times in each tank, the second and third times in each tank The extract is used as the solvent for the first and second extraction in the next tank respectively. The first extract of each tank is put into the liquid storage tank, and the extract is obtained after filtration, concentrated by rotation, added water to a certain volume, filtered, and the filtrate is placed on D101 Type macroporous resin, first eluted with 3BV water, followed by 4BV65% ethanol solution, collected the ethanol eluate, concentrated to a relative density of 1.05, spray-dried the supernatant, dried the precipitate under reduced pressure, mixed evenly, and obtained the extracted Material 50g.

Embodiment 3

[0023] Grind Morinda officinalis leaves, take 5kg, use 70% ethanol solution as solvent, carry out multi-tank dynamic countercurrent extraction, take 4 tanks as a cycle unit, extract 3 times in each tank, the second and third times in each tank The extract is used as the solvent for the first and second extractions of the next tank respectively. The first extract of each tank is put into the liquid storage tank, and the extract is obtained after filtration. The extract is concentrated by rotation, and water is added to a certain volume, filtered, and the filtrate is HPD -400 type macroporous resin, first eluted with 3BV water, then eluted with 6BV65% ethanol solution, collected the ethanol eluate, concentrated to a relative density of 1.1, spray-dried the supernatant, dried the precipitate under reduced pressure, and mixed evenly. 173 g of extract was obtained.

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PUM

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Abstract

The invention relates to a method for extracting effective components of Morinda officinalis leaves. The specific steps include: pulverizing Morinda officinalis leaves, performing multi-tank dynamic countercurrent extraction, filtering the extract, rotating and concentrating, adding water to the concentrate to a certain volume, filtering, and filtering the filtrate. The macroporous resin is firstly eluted with water, followed by elution with ethanol solution, the ethanol eluate is concentrated, the supernatant is spray-dried, the precipitate is dried under reduced pressure, and the extract is obtained by mixing evenly. The invention has a high extraction rate and is easy to realize industrial scale-up.

Description

technical field [0001] The invention relates to an extraction method of active ingredients of medicinal plants, in particular to an extraction method of active ingredients of Morinda officinalis leaves. Background technique [0002] Morinda officinalis ( Morinda citrifolia L.) Also known as Morinda officinalis and Morinda officinalis, commonly known as noni and wax gourd, it is a plant of the genus Morinda officinalis in the Rubiaceae family. Its leaves, roots, bark and fruits can treat diseases. Morinda citrifolia has been used as a health and medicinal drink in the folk for two thousand years, especially in the southern Pacific islands, such as Polynia in Tahiti, among the indigenous peoples of Malaysia, Australia, and Hawaii. It is an essential daily health care product. The comprehensive results of clinical pharmacological research show that Morinda officinalis can maintain the normal function of human cell tissue, enhance human immunity, change the ecology of bacteri...

Claims

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Application Information

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IPC IPC(8): A61K36/746A61P1/02A61P11/04A61P11/00A61P31/12A61P25/00A61P19/08A61P19/04A61P17/00A61P39/06A61P17/16A61K127/00
Inventor 刘东锋万冬梅
Owner NANJING ZELANG MEDICAL TECH
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