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Medicinal composition for high-androgen polycystic ovary syndrome

A high androgen, polycystic ovary technology, applied in drug combinations, medical raw materials derived from arthropods, pharmaceutical formulations, etc., can solve problems such as fetal harm, pelvic adhesions, and ovarian damage.

Active Publication Date: 2013-05-08
上海泰坤堂中医医院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs not only cannot effectively treat all PCOS, but also have defects such as low pregnancy rate and high miscarriage rate
Surgical puncture techniques are also used in the treatment of PCOS, which may cause damage to the ovaries, or cause pelvic adhesions and potential harm to the fetus

Method used

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  • Medicinal composition for high-androgen polycystic ovary syndrome
  • Medicinal composition for high-androgen polycystic ovary syndrome
  • Medicinal composition for high-androgen polycystic ovary syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The preparation of embodiment 1 decoction

[0050] Take 0.6g of hippocampus, 15g of fairy spleen, 12g of fritillaria, 15g of psoralen, 12g of tortoise shell, 12g of antler slices, 15g of saponin thorn and 15g of calamus, rinse with water, soak in the container for more than 2 hours, and then fry And the following traditional decocting process, decocting at normal pressure for 20 minutes to filter out the medicinal liquid.

Embodiment 2

[0051] The preparation of embodiment 2 ointment

[0052] Take 6g of hippocampus, 150g of fairy spleen, 120g of fritillaria, 150g of psoralen, 120g of tortoise shell, 120g of antler slices, 150g of saponin thorn and 150g of calamus, rinse with water, soak in the container for more than 2 hours, and then fry and mix The following traditional decoction process, after decocting under normal pressure, filter out the liquid medicine and concentrate the liquid medicine under reduced pressure. During the concentration process of the liquid medicine, add rock sugar, maltose and rice wine and other required sugars and necessary auxiliary materials, and stir to collect the paste .

Embodiment 3

[0053] Embodiment 3 clinical observation

[0054] Patient entry criteria: 1) Basal body temperature (BBT) continued monophasic 2 years after menarche, oligomenorrhea or amenorrhea; 2) Blood androgen increased: blood testosterone (T) increased or testosterone / estradiol logarithmic ratio (logT / E 2 )>0.97; can be combined with increased 17α-hydroxyprogesterone (17α-OHP) and androstenedione; 3) B-ultrasound examination shows that the ovarian volume increases (≥6ml), and the number of follicles with a diameter of 2-9mm on a plane in the cortex> 10; 4) No response to clomiphene treatment, and the hormone therapy used has been stopped for more than 3 months; 5) Congenital adrenal hyperplasia, small follicle syndrome, Cushing's syndrome, androgen-secreting ovarian and adrenal tumors, etc. were excluded disease; 6) aged 18 to 40 years old. All patients have been treated by traditional Chinese medicine and Western medicine for more than half a year, but no ovulation or pregnancy occu...

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Abstract

The invention relates to a medicinal composition for a high-androgen polycystic ovary syndrome. The medicinal composition comprises a Chinese medicinal composition and a chemical medicament, wherein the Chinese medicinal composition comprises the following medicinal materials: epimedium, caladium, fructus psoraleae, sliced deerhorn, sea horse, tortoise plastron and the like, and does not contain rhubarb and Chinese angelica. The medicinal composition can reduce the level of androgen and androgen receptors of polycystic ovary syndrome (PCOS) patients, improve the level of sex hormone binding globulin, reduce the level of free testosterone, improve the level of in-vivo estrogen further, improve the growth and development of follicles, and improve the ovulation rate and pregnancy rate of thepatients.

Description

technical field [0001] The present invention relates to a pharmaceutical composition for treating polycystic ovary syndrome, in particular to a Chinese medicinal composition which is compatible with various Chinese medicinal materials according to the phases of monarch, minister, adjuvant, and make, and a pharmaceutical combination in which chemical drugs are used in conjunction. For the treatment of hyperandrogen polycystic ovary syndrome. Background technique [0002] Polycystic ovary syndrome (Polycystic Ovary Syndrome, PCOS) was proposed by Stein and Leventhal in 1935. A type of disease manifested. This disease is a common endocrine disease in women and mostly causes reproductive disorders, and its incidence rate accounts for 5%-10% of women of childbearing age. Studies in recent years have widely recognized that women with PCOS have different degrees of insulin resistance, and insulin resistance accompanied by hyperinsulinemia can cause many clinical symptoms, such as...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8966A61K36/899A61K36/90A61K36/902A61K36/9064A61K36/9066A61K45/00A61P15/08A61P5/28A61K31/565A61K31/567A61K31/573A61K31/585A61K33/26A61K35/32A61K35/56A61K35/62A61K35/64A61K35/586A61K35/60
Inventor 俞谨潘芳武大圣
Owner 上海泰坤堂中医医院有限公司
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