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A kind of genistein dropping pill and preparation method thereof

A technology of genistein and dripping pills, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., to achieve the effects of convenient administration, high bioavailability, and low price

Inactive Publication Date: 2011-12-21
李荣立
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no genistein drop pill preparation with high drug content, rapid drug release, rapid effect, stable quality and high bioavailability in clinical practice.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 100g polyethylene glycol 4000 according to the prescription, place it in a water bath at 80°C and heat it to melt, add 50g genistein under stirring, stir at 80°C to make it evenly dispersed, transfer the liquid medicine to the dripping pill machine for constant temperature storage In the container, the dripping rate is 60 drops / min, the coolant is liquid paraffin, and the coolant temperature is 15℃. Adjust the weight of the dripping pill to 60 mg to make a dripping pill. Remove the coolant on the surface of the dripping pill. .

Embodiment 2

[0030] Take 150g polyethylene glycol 6000 according to the prescription, heat and melt it in a water bath at 80°C, add 50g genistein under stirring, stir at 80°C to make it evenly dispersed, and transfer the liquid medicine to the dripping pill machine for constant temperature storage In the container, the dripping rate is 60 drops / min, the coolant is liquid paraffin, and the coolant temperature is 5℃. Adjust the weight of the dripping pill to 50 mg to make a dripping pill. Remove the surface cooling agent of the dripping pill. .

Embodiment 3

[0032] Take 200g of polyethylene glycol 2000 according to the prescription, heat and melt it in a water bath at 80°C, add 50g of the drug under stirring, stir at 80°C to make it evenly dispersed, and transfer the drug solution to the constant temperature storage tank of the dropping pill machine. The dripping rate is 60 drops / min, the coolant is dimethyl silicone oil, and the coolant temperature is 10°C. Adjust the weight of the dripping pill to 65 mg to make a dripping pill, remove the surface coolant of the dripping pill, and pack it separately.

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PUM

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Abstract

The invention discloses a genistein drop pill preparation and a preparation method thereof. The genistein dropping pill provided by the invention is prepared from the main drug genistein and a matrix. The weight ratio of genistein to substrate is preferably 1:2-6. The genistein dripping pill preparation provided by the invention has the advantages of high drug content, rapid drug release, rapid effect, stable quality, high bioavailability, convenient administration, low price, convenient production, carrying and storage, and the like.

Description

Technical field [0001] The invention relates to a genistein dripping pill preparation and a preparation method thereof, and belongs to the field of medicine. Background technique [0002] Genistein (also known as genistein, 4',5,7-trihydroxyisoflavone, genistein, genistein), soluble in DMSO and ethanol, almost insoluble in water, the structure is as follows: [0003] [0004] Genistein is an isoflavone compound derived from legumes and dentate plants, and its chemical name is 4',5,7-trihydroxyisoflavone. It is the main active ingredient of soybean isoflavones, which has an estrogen-like effect in body metabolism, and is called a phytoestrogens. Genistein has a variety of pharmacological effects and biological activities such as preventing early atherosclerosis and chronic vascular disease, anti-tumor, and women's menopausal syndrome. Genistein is a potent inhibitor of tyrosine protein kinase and topoisomerase, which can inhibit tumor growth and metastasis in multiple ways by regu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/352A61K47/34A61P9/10A61P15/12A61P35/00
Inventor 李荣立赵素芬
Owner 李荣立
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