A kind of subcutaneous soft tissue filling localized fibrin compound that can be used for facial beauty and its preparation method

Abstract

The invention relates to a facial fibrous protein composite filled and positioned in subcutaneous soft tissues, and a preparation method thereof. The composite comprises the following raw materials by weight: 10.0 to 95.0g of five-time autogenous concentrated plasma, 0.001 to 0.10g of calcium chloride, 1.0 to 15.0g of sodium sulfite, 0.005 to 0.5g of recombinant human vascular endothelial growth factor freeze-dried powder, 0.005 to 0.5g of recombinant human basic fibroblast growth factor freeze-fried powder, 0.1 to 10.0g of amino-silanized ferroferric oxide magnetic particle, and 5.0 to 90.0g of 0.1mol / L phosphate buffered saline injection. The autogenous concentrated plasma can form a stable composite fibrous protein scaffold in several hours under the double actions of calcium chloride and sodium sulfite to meet the requirement of plastic surgery; meanwhile, the composite can achieve the accurate positioning and filling effect under the action of an external magnetic field; moreover, the composite does not have irritability, and is high in safety and easy to prepare, has a good filling effect, promotes the proliferation of surrounding cells in which the composite is filled, restores tissues of the depression part and achieves the strengthening, filling and restoration effects.

Description

technical field [0001] The invention belongs to the technical fields of beauty care and medicine and biology, and relates to a subcutaneous soft tissue filling and positioning fibrin compound that can be used for facial beauty and a preparation method thereof. Background technique [0002] Human aging is a ubiquitous process of physiological changes, and the skin is the most exposed organ in the aging process. A series of skin physiological function and histological structure changes and clinical symptoms produced under the skin, mainly manifested as the appearance of pigment spots, the production of wrinkles, the relaxation of the skin and the absorption and atrophy of local tissues to produce depressions. At present, people have carried out research on gene regulation and genetic engineering based on various theories of aging mechanisms, starting from the internal and external incentives of skin aging, and developed a series of external preparations, beauty and skin care p...

AI Technical Summary

Problems solved by technology

Although many defects and deficiencies have hindered the widespread application of non-biological materials, their direct effects have been prompting people to look for more ideal non-biological materials.

Although in recent years, autologous tissues have been used as fillers without rejection and side effects, but the safety standards of the process and laboratory qualifications of autologous tissues are not easy to control, expensive, and slow to take effect. It takes more than half a year to see results, and the course of treatment is relatively long

[0039] In addition, although non-biological sources of materials have obvious filling effects, "immediate results" and long-lasting time, the use of non-biological materials for filling has low safety, and the facial contour will change with age, and fillers will become new defects. The cosmetic doctor must make new repairs for the filling site; moreover, if there is any problem with the permanent filling, it cannot be degraded and can only be removed together with the original tissue of the human body

In addition, for some self-filling materials with good effects, there is no rejection reaction, the effect is obvious, and the duration is longer. However, due to its migration in the skin, the skin after filling is unnatural, which affects the appearance of the skin. Balance, The sensory effect is not ideal, and various reasons lead to limited application

Images