A kind of subcutaneous soft tissue filling localized fibrin compound that can be used for facial beauty and its preparation method

A fibrin and soft tissue technology, applied in the fields of beauty care and medical biology, can solve the problems that hinder the wide application of non-biological materials, poor control of safety standards, and affect the balance of skin appearance, etc., to achieve good filling effect, high strength, good protection effect

Active Publication Date: 2011-12-21
董萍 +1
View PDF5 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many defects and deficiencies have hindered the widespread application of non-biological materials, their direct effects have been prompting people to look for more ideal non-biological materials.
Although in recent years, autologous tissues have been used as fillers without rejection and side effects, but the safety standards of the process and laboratory qualifications of autologous tissues are not easy to control, expensive, and slow to take effect. It takes more than half a year to see results, and the course of treatment is relatively long
[0039] In addition, although non-biological sources of materials have obvious filling effects, "immediate results" and long-lasting time, the use of non-b

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of subcutaneous soft tissue filling localized fibrin compound that can be used for facial beauty and its preparation method
  • A kind of subcutaneous soft tissue filling localized fibrin compound that can be used for facial beauty and its preparation method
  • A kind of subcutaneous soft tissue filling localized fibrin compound that can be used for facial beauty and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] Example 1: Preparation steps of aminosilylated triferromagnetic particles

[0089] (1) The liquid phase co-precipitation method was used to separate a certain concentration of FeCl 3 ·H 2 O and FeCl 2 ·4H 2 O was co-precipitated in ammonia solution. After static stratification and removal of supernatant, tetramethylammonium hydroxide solution with a concentration of 20-30% was added immediately, and then dispersed by ultrasonic method, and the larger magnetic particles were removed by filtration. , a solution with a gray-brown color and uniform particle size can be obtained;

[0090] (2) Take a certain dose of magnetic particle solution and add it to 100-200ml isopropanol solution; disperse the magnetic nanoparticles by ultrasonic method; at the same time, add 3-6g polyethylene glycol (PEG- 4000), continue to stir for 10-20min, add an appropriate amount of distilled water, and then add 0.1-0.3ml of ethyl orthosilicate (TESO) to hydrolyze to form a silicon shell laye...

Embodiment 2

[0091] Embodiment 2: A kind of preparation method of subcutaneous soft tissue filling and positioning fibrin complex that can be used for facial beauty

[0092] A subcutaneous soft tissue filling and positioning fibrin complex that can be used for facial beauty is composed of the following raw materials with a preferred weight ratio:

[0093]

[0094] A specific preparation method of subcutaneous soft tissue filling and positioning fibrin complex that can be used for facial beauty (taking preparation of 100ml as an example):

[0095] (1) In strict accordance with the standardized requirements of human blood drawing, quickly collect blood from the middle cubital vein of the recipient, and collect it into a sterile dry blood collection tube containing anticoagulant at the same time; gently invert and mix 6 to 8 times to remove 4000rpm·min -1 Centrifuge for 10 min at a high speed; at this time, the blood in the centrifuged blood collection tube can be seen to the naked eye ha...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a facial fibrous protein composite filled and positioned in subcutaneous soft tissues, and a preparation method thereof. The composite comprises the following raw materials by weight: 10.0 to 95.0g of five-time autogenous concentrated plasma, 0.001 to 0.10g of calcium chloride, 1.0 to 15.0g of sodium sulfite, 0.005 to 0.5g of recombinant human vascular endothelial growth factor freeze-dried powder, 0.005 to 0.5g of recombinant human basic fibroblast growth factor freeze-fried powder, 0.1 to 10.0g of amino-silanized ferroferric oxide magnetic particle, and 5.0 to 90.0g of 0.1mol/L phosphate buffered saline injection. The autogenous concentrated plasma can form a stable composite fibrous protein scaffold in several hours under the double actions of calcium chloride and sodium sulfite to meet the requirement of plastic surgery; meanwhile, the composite can achieve the accurate positioning and filling effect under the action of an external magnetic field; moreover, the composite does not have irritability, and is high in safety and easy to prepare, has a good filling effect, promotes the proliferation of surrounding cells in which the composite is filled, restores tissues of the depression part and achieves the strengthening, filling and restoration effects.

Description

technical field [0001] The invention belongs to the technical fields of beauty care and medicine and biology, and relates to a subcutaneous soft tissue filling and positioning fibrin compound that can be used for facial beauty and a preparation method thereof. Background technique [0002] Human aging is a ubiquitous process of physiological changes, and the skin is the most exposed organ in the aging process. A series of skin physiological function and histological structure changes and clinical symptoms produced under the skin, mainly manifested as the appearance of pigment spots, the production of wrinkles, the relaxation of the skin and the absorption and atrophy of local tissues to produce depressions. At present, people have carried out research on gene regulation and genetic engineering based on various theories of aging mechanisms, starting from the internal and external incentives of skin aging, and developed a series of external preparations, beauty and skin care p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L27/22A61L27/50
Inventor 杨永鹏董萍丁克祥左夏林丁宇罗迎霞黄学忠丁振华
Owner 董萍
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap