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Application of Discarded 99Mo-99m Technetium Generator in Cerebral Blood Flow Diagnosis

A technology of technetium generator and cerebral blood flow map, which is applied in the application field of 99molybdenum-99m technetium generator in the detection of cerebral blood flow map, can solve the problems of high radioactive intensity, long retention time, and affecting sensitivity, etc. Achieve the effects of low radioactive intensity, short half-life and high sensitivity

Inactive Publication Date: 2011-12-28
周莉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the process of using the above-mentioned technology, there are many defects: 113m indium as a tracer, although 113 Indium is pure gamma-ray, half-life (T 1 / 2 ) is short (6.02 hours), it is an ideal tracer, but the radioactivity is high, and it will pollute the environment, so protection needs to be strengthened; in addition, the eluent of the generator is 0.05mol / L hydrochloric acid (HCl), and hydrochloric acid is Strong acid, the volume of its injection must be strictly controlled; the above two points have become serious constraints for the development of cerebral blood flow mapping; the tracer using iodine-131 as brain mapping has more defects, and it mainly emits β rays when it decays, and γ - There are very few rays, which greatly affects the sensitivity of detection, and the half-life is long (8.04 days), so it stays in the body for a long time, which is harmful to the body; its radioactivity is high and pollutes the environment; it is effective for hypothyroidism and thyroiditis Patients do not adapt, etc., so it is not an ideal tracer

Method used

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  • Application of Discarded 99Mo-99m Technetium Generator in Cerebral Blood Flow Diagnosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: The selected subjects are normal healthy young people.

[0031] 1, 99 Mo— 99m Tc( 99 molybdenum-- 99m technetium) generator (referred to as 99m technetium generator) (Beijing Atomic Hi-Tech Co., Ltd.); eluent: 0.9 % NaCl.

[0032] 2. Will 99m The technetium generator was rinsed with 0.9% NaCl solution as eluent. The specific operation method is to insert the vial containing 0.9% NaCl (5 ml) upside down 99m At the entrance of the technetium generator, insert the negative pressure bottle into the outlet of the generator. Using the principle of negative pressure, 0.9% NaCl liquid flows into the negative pressure bottle through the generator, and the tracer Na 99m TcO4 (ie 99m TcO4). Remove the negative pressure bottle for later use.

[0033] 3. The above eluted 99m TcO4 tracer uses activity meter to take 75uCi / 0.1ml (microcurie milliliter) for cerebral blood flow detection.

[0034]The specific methods are as follows: (1) Prepare the patient. The ...

Embodiment 2

[0037] The implementation object, selected materials and process are the same as Example 1.

[0038] 99m TcO4 tracer injection dose and injection volume. Choose 100uCi / 0.1ml and 113m indium and 131 The results measured by I-OIH as a tracer are basically similar. The results are as follows: The time to pass through the left and right hemispheres of the brain is 7.0 seconds and 6.5 seconds, respectively. It shows that the blood supply to the brain is generally normal.

Embodiment 3

[0040] The implementation object, selected materials and process are the same as Example 1.

[0041] 99m TcO4 tracer injection dose and injection volume. Choose 50uCi / 0.3ml and 113m indium and 131 The results measured by I-OIH as a tracer are the most approximate. The results are as follows: the time to pass through the left and right hemispheres of the brain is 6.5 seconds and 6.8 seconds, respectively. It shows that the blood supply to the brain is generally normal.

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Abstract

The invention relates to the application of discarded 99molybdenum-99m technetium generator after imaging, in particular to the application of discarded 99molybdenum-99m technetium generator in cerebral blood flow diagram detection. The method mainly solves the problems that the tracer in the prior art has a large amount of radiation to patients, pollutes the environment, has a short half-life, has low detection sensitivity, has large toxic and side effects on the human body, is easy to obtain, is cheap, and has strict requirements on the volume of the eluent. The technical scheme is (1) leaching the 99molybdenum-99m technetium generator with 0.9% NaCl as the eluent to obtain the tracer 99mTcO4; (2) intravenously Injection; the injection dose and injection volume of the 99mTcO4 tracer intravenous injection are: 99mTcO4 tracer injection dose 50uCi (microcurie) to 100uCi; injection volume is 0.1m1 ~ 1.0ml; (3) after intravenous injection Data point collection; (4) After data collection and smoothing, the relevant parameters are calculated by a microcomputer to obtain a cerebral blood flow map. The invention has the advantages of scientific method, high sensitivity, low radioactive energy, less radiation received by patients, no environmental pollution, short half-life, short residence time in the body, repeated inspection in a short time, no chemical reaction in the body, and no harm to the human body. The toxic and side effects are small, easy to obtain and cheap; the eluent of the generator is cheap and has no toxic and side effects.

Description

[0001] technical field [0002] The present invention relates to discarded 99 molybdenum-- 99m Use of technetium generators, specifically discarded after imaging 99 molybdenum-- 99m The application of a technetium generator in the detection of cerebral blood flow diagram belongs to the field of medical equipment. Background technique [0003] The brain is an important organ of the human body, and its oxygen consumption is relatively large: the weight of the brain accounts for only about 2% of the body weight, but its oxygen consumption accounts for 20% of the whole body's oxygen consumption. All the oxygen needed by the brain is supplied by the blood, so there must be enough blood supply to the brain to function normally. The standard to measure the blood supply to the brain is the cerebral blood flow. Once the cerebral blood flow decreases, the oxygen and energy supply to the brain cells will also decrease. As long as the brain tissue is ischemic for more than 10 second...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61B5/0275
Inventor 周莉于周涛于徽钦
Owner 周莉