Copolycondensation synthesized polylactic acid-glycollic acid catalyzed by biomass creatinine

Abstract

The invention relates to a technological method for catalyzing lactic acid and glycollic acid into copolycondensation by a biomass creatinine so as to synthesize a medical biodegradable material polylactic acid-glycollic acid. With the arginine metabolite creatinine in human body as the catalyst, industrial lactic acid (LA, 85% aqueous solution) and glycollic acid (GA, 95%) as comonomers, the medical degradable material polylactic acid-glycollic acid of high biological safety can be obtained through solvent-free and two-step bulk copolycondensation. The invention has the characteristics of green technology, low raw material cost, simple operation and easy industrial implementation; the catalyst creatinine is of high biocompatibility and biological safety and is free of cytotoxicity, and the synthesized polylactic acid-glycollic acid contains no metal and other toxic residues; the synthesized polylactic acid-glycollic acid has a molecular weight adjustable in the range of 1.8-17.7*104; and the synthesized polylactic acid-glycollic acid of the invention is suitable to be used as implanted hard tissue repairing materials, surgical sutures, targeting and controlled release drug carriers.

Description

technical field [0001] The invention belongs to the technical field of medical biodegradable materials, and relates to the synthesis of high biosafety medical biodegradable polylactic acid by using biomass creatinine (the product of arginine metabolism in the human body) as a catalyst, and taking lactic acid and glycolic acid as raw materials through co-condensation reaction - Glycolic acid (lactic-co-glycolic acid) process. Background technique [0002] Polylactic acid-glycolic acid PLGA is an important medical biodegradable material with good biocompatibility, bioabsorbability and biodegradability. Since polylactic acid-glycolic acid is made by the copolymerization of lactic acid and glycolic acid, it has the advantages of two homopolymer polyester materials (polylactic acid PLA, polyglycolic acid PGA). Polylactic acid-glycolic acid not only has good biocompatibility, but also its material strength, degradation rate, and mechanical properties can be adjusted by changing ...

AI Technical Summary

Problems solved by technology

The purpose of the present invention is to solve the problem of potential safety hazards in the synthetic polylactic acid-glycolic acid material used in the field of human medical use by using stannous chloride as a catalyst in the synthesis of polylactic acid-glycolic acid by the existing polycondensation method, and to provide a biological Material creatinine catalyzed direct co-condensation method to synthesize polylactic acid-glycolic acid

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