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Method for extracting and purifying glycyrrhizic acid by ion-exchange fibers

A technology of ion exchange fiber and glycyrrhizic acid, applied in the field of ion exchange fiber extraction and purification of glycyrrhizic acid, can solve the problems of unfavorable large-scale production of glycyrrhizic acid, many production links, high production cost, etc., and achieve controllable product quality standards, improve purity and Yield, the effect of simple production equipment

Inactive Publication Date: 2012-01-04
BEIJING INST OF CLOTHING TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] But the efficiency of these methods is low, the purity of the isolated glycyrrhizic acid is low, the repeatability is poor, the production links are many, the material consumption is large, causing serious environmental pollution, the production cost is high, and the cycle is long.
Make the indicators in the separation process difficult to monitor
Unfavorable large-scale production of glycyrrhizic acid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Wash, dry and pulverize licorice, weigh 20g of powder, adjust its pH to 7 with 160mL of ethanol aqueous solution with a volume ratio of 70%, decoct at 70°C for 5.0 hours, then decoct with 150mL of water for 4.0 hours, combine Decoction and cooling, adjust the pH value of the solution to 11.0, at a flow rate of 1.5BV h -1 , through a strongly basic ion-exchange fiber column with a weight of 1.0 g and a bed volume of 10 mL for adsorption. Then at a flow rate of 4.0BV·h -1 , 3 times the column volume of water for elution, followed by 5 times the column volume of 65% ethanol and hydrochloric acid (65% ethanol: 3mol L -1 The mixture of hydrochloric acid (volume ratio 4:1) was eluted, and ethanol was recovered to obtain glycyrrhizic acid extract, wherein the content of glycyrrhizic acid was 63.17%, and the yield was 4.54%.

Embodiment 2

[0032] Wash, dry and pulverize licorice, weigh 200g of powder, use distilled water with pH=7 and ethanol to make 1800mL aqueous solution with a volume ratio of 70% ethanol, extract at 75°C for 5.0 hours, and decoct with 1600mL of the mixed solution for 3.0 hours . The yield of crude glycyrrhizic acid obtained was 11.53%, and the purity was 32.61%. The pH value of the upper column chemical solution is 9.0, and the flow rate is 2.0BV·h -1 , the liquid concentration is 0.3mg·mL -1 Under the conditions of 12.0g and 120mL bed volume, the strong alkaline ion exchange fiber column is used for adsorption. The desorbent is 60% ethanol and 3mol L -1 Hydrochloric acid mixture (volume ratio 4:1) 7BV, elution flow rate 3.0BV h -1 Perform elution. The ethanol was recovered to obtain a purified glycyrrhizic acid extract, wherein the content of glycyrrhizic acid was 61.21%, and the yield was 4.32%.

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Abstract

The invention provides a method for extracting and purifying glycyrrhizic acid by ion-exchange fibers. The method comprises the following steps of: cleaning, drying and crushing a liquorice medicinal material, decocting and leaching, and adsorbing by using an ion exchange fiber column under conditions that the concentration of the glycyrrhizic acid stock solution is between 0.04 and 6.0g.L<-1>, temperature is between 10 and 85 DEG C, the flowing speed is between 0.3 and 8.0BV.h<-1> (BV is short for column volume), and the pH value is between 6.0 and 12.0; eluting with eluent at eluting temperature of between 10 and 90 DEG C and flowing speed of between 0.2 and 10.0BV.h<-1>, wherein the eluent is prepared from water, alcohol or mixture of water and alcohol, as well as an HCl pH regulating agent with the concentration of between 0.5 and 6.0mol.L<-1> in the volume ratio of 2-10:1; and collecting the eluent, and reclaiming organic matters to obtain glycyrrhizic acid extract powder. The method has simple process, easily available equipment, low operation cost, remarkable energy-saving effect and high product purity, and is suitable for production in scale.

Description

technical field [0001] The invention relates to a method for extracting, separating and purifying medicinal components of natural plants by using ion-exchange fibers, in particular to a method for extracting and purifying glycyrrhizic acid by using ion-exchange fibers. Background technique [0002] Ion exchange fiber (Ion Exchange Fiber, IEF) is a fibrous ion exchange adsorption material, which is composed of many fiber monofilaments with a small diameter ranging from 20 to 300 μm. It is composed of fixed ions and mobile ions with the opposite sign to the fixed ions. When in contact with a solution capable of dissociating compounds, the active ions of the ion exchange fiber are exchanged with ions of the same sign in the solution, so it is called ion exchange fiber. Compared with granular ion exchangers, ion exchange fibers have the characteristics of large specific surface, small diameter, fast adsorption and desorption, large exchange capacity, easy regeneration, and vari...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00C07H15/256C07H1/08
Inventor 刘廷岳聂素双崔成民王闯李春红
Owner BEIJING INST OF CLOTHING TECH
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