Chinese lizardtail rhizome or herb rootstock total effective fraction and preparation method and application thereof

A kind of technology of effective parts and grass rhizomes, applied in the field of traditional Chinese medicine extracts and preparations thereof

Active Publication Date: 2012-01-25
CHENGDU DIAO PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the defects of the existing insulin sensitizer drugs, the present invention provides an extract of the total effective parts of Rhizome Rhizome with insulin sensitizing effect and its preparation method. The extract can be used as an insulin sensitizer drug for insulin resistance-related disease treatment and prevention

Method used

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  • Chinese lizardtail rhizome or herb rootstock total effective fraction and preparation method and application thereof
  • Chinese lizardtail rhizome or herb rootstock total effective fraction and preparation method and application thereof
  • Chinese lizardtail rhizome or herb rootstock total effective fraction and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1: Preparation of the Extract of the Total Effective Parts of Rhizome of Sanbaicao

[0063] 1000g of rhizome of Sanbaicao, add 8L of methanol after crushing, heat and reflux for extraction for 1.5 hours, add 6 liters of methanol to the filter residue, heat and reflux for extraction for 1 hour, and filter. The two filtrates were combined and concentrated in vacuo to obtain 87 g of extract. Dissolve the extract with 2L of hot water, then extract 4 times with an equal volume of ethyl acetate, extract the extract after recovering the ethyl acetate under reduced pressure, and obtain the extract, vacuum it into a dry powder, and obtain 22g of the total effective parts of the rhizome of Sanbaicao Extract A, the sum of total lignans and total fatty acids contained in it is 90% of the total weight of the total effective parts extract (wherein total lignans account for 57%, and total fatty acids account for 33%).

Embodiment 2

[0064] Example 2: Preparation of the Extract of the Total Effective Parts of Rhizome of Sanbaicao

[0065] 1000g of rhizome of Sanbaicao, crushed, add 8L of 90% ethanol solution, extract by heating and reflux for 1.5 hours, add 6 liters of 70% ethanol solution to the filter residue, extract by heating and reflux for 1 hour, and filter. The two filtrates were combined and concentrated until there was no alcohol smell. Add an appropriate amount of water to the concentrated solution and extract it with an equal volume of ethyl acetate for 4 times. After the extract is decompressed and recovered ethyl acetate, the extract is obtained, and vacuumized into a dry powder to obtain 30 g of the total effective part extract B , the sum of total lignans and total fatty acids contained in it is 62% of the total weight of the total effective parts extract (wherein total lignans account for 39%, and total fatty acids account for 23%).

Embodiment 3

[0066] Example 3: Preparation of the Extract of the Total Effective Parts of Rhizome of Sanbaicao

[0067] 1000g rhizome of Sanbaicao, add 8L of 70% ethanol solution after crushing, heat and reflux for extraction for 1.5 hours, add 6 liters of 50% ethanol solution to the filter residue, heat and reflux for extraction for 1 hour, and filter. The two filtrates were combined and concentrated until there was no alcohol smell. Add appropriate amount of water to the concentrated solution and extract it with an equal volume of ethyl acetate for 4 times. After the extract is decompressed and recovered ethyl acetate, the extract is obtained, and vacuumized into dry powder to obtain 43g of the total effective part extract of Rhizome of Rhizoma chinensis C. , the sum of total lignans and total fatty acids contained in it is 40% of the total weight of the total effective part extract (wherein total lignans account for 24%, and total fatty acids account for 16%).

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Abstract

The invention provides a Chinese lizardtail rhizome or herb rootstock total effective fraction extract, which contains Chinese lizardtail rhizome or herb rootstock total lignan and total fatty acid and has the percentage by weight 10-90 percent. The invention further provides a preparation method and application of a Chinese lizardtail rhizome or herb rootstock total effective fraction. The Chinese lizardtail rhizome or herb rootstock total effective fraction extract can be used for preparing an insulin sensitizer medicinal preparation, has a good insulin sensitizing function, can be preparedinto various dosage forms such as oral tablets, capsules and the like, is suitable for treating insulin resistance-relevant diseases (such as type II diabetes, hypertension, obesity, nonalcoholic fatty liver and heart cerebrovascular thrombosis disease), and has the advantages of remarkable curative effect, low price, convenience for using, and the like.

Description

technical field [0001] The present invention relates to a traditional Chinese medicine extract and its preparation method and application, in particular to an extract of the total effective part of Rhizome of Rhizoma Rhizoma Rhizoma Rhizome and its preparation method, as well as its application in the preparation of insulin sensitizer pharmaceutical preparations . Background technique [0002] In the past 20 years, scientific research has found that type II diabetes, high blood pressure, obesity, non-alcoholic fatty liver, and cardiovascular and cerebrovascular thrombotic diseases belong to metabolic syndrome, and their common basis is insulin resistance. Metabolic syndrome is also known as insulin resistance syndrome. [0003] With the change of environment and lifestyle, the incidence of metabolic syndrome is high and the growth trend is rapid. For example, type II diabetes, the current incidence rate is 30% higher than that of 4 years ago. There are 250 million patients...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P3/04A61P5/50A61K31/357A61K31/201A61P7/02A61P9/12A61K36/78A61K31/20A61P3/10A61P1/16A61K125/00A61K31/341
Inventor 晏菊芳李麒麟及元乔杨腾邓玉碧杨正平何玲张燕陈欣张蔚瑜
Owner CHENGDU DIAO PHARMA GROUP
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