Artificial lens implantation flexible hydrosol auxiliary agent and preparation method thereof

Abstract

The invention discloses an artificial lens implantation flexible hydrosol auxiliary agent, which comprises the following components in percentage by mass: 0 to 5.0 percent of disodium hydrogen citrate, 0 to 2.5 percent of monosodium hydrogen citrate, 1.0 to 20 percent of carboxyl-propyl methylcellulose, 0.05 to 5.0 percent of sodium chondroitin sulfate, 0.1 to 10 percent of potassium chloride, 0.05 to 10 percent of magnesium chloride, 0.1 to 2.5 percent of sodium acetate, 0.1 to 1.0 percent of sodium chloride, and 44 to 99 percent of sterile double-distilled water. The artificial lens implantation flexible hydrosol auxiliary agent has excellent flow properties, can effectively reduce organism exclusion and prolong the service life of a lens, and particularly can better slow down postoperative lens turbidity, so that the artificial lens implantation flexible hydrosol auxiliary agent is expected to fundamentally reduce pains of patients and save expensive cost caused by repeated operations, and has a great expectancy of social benefits and economic benefits.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to a flexible hydrosol auxiliary agent for intraocular lens implantation and a preparation method thereof. Background technique [0002] Cataract is a common eye disease that can cause clouding of the lens in mild cases and lead to blindness in severe cases. According to the 2010 annual report of the World Health Organization, about 48% of the 18,000,000 blind people in the world are caused by cataracts caused by aging. In western developed countries, such as the United States, 42% of the population in the 52-64 age group exhibits lens changes caused by aging; in the 65-74 age group, this proportion rises to 60%; The proportion is as high as 91%. At present, China has the largest blind population in the world, about 6.6 million people, about 50% of which are caused by cataracts; and this number will increase significantly, because according to statistics, by 2020 there will be 200...

AI Technical Summary

Problems solved by technology

[0006] However, these flexible hydrosol adjuvants for intraocular lens implantation generally have the following deficiencies: 1) Due to the large number of polar carboxylic acid groups and sulfate group functional groups, the surface electron density is greatly increased and the interaction between the complex and body fluids is reduced. interface energy; at the same time, a large number of functional groups reduces the diffusion of calcium ions and phosphates and promotes the adsorption of calcium ions on the lens surface, thereby providing nucleation points to induce crystallization of impurities; 2) the presence of a large number of phosphates will induce supersaturated deposition of calcium phosphate, Directly lead to a decrease in product stability and eventually clouding of the lens

According to our clinical follow-up results, in a few cases, the intraocular lens will produce turbidity 3 to 4 months after the operation, which directly leads to product failure and the patient has to undergo surgery again

Images