Magnetic chitosan/doped rare earth compound particles and preparation method thereof

A rare earth composite and composite particle technology, which is used in pharmaceutical formulations, preparations for in vivo tests, and medical preparations with inactive ingredients, etc., to achieve mild conditions, good magnetic responsiveness and fluorescence characteristics, and good biocompatibility. Effect

Inactive Publication Date: 2012-01-25
WUHAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Magnetic chitosan/doped rare earth compound particles and preparation method thereof
  • Magnetic chitosan/doped rare earth compound particles and preparation method thereof
  • Magnetic chitosan/doped rare earth compound particles and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Weigh 0.2377g (0.64mmol) LaCl 3 ·7H 2 O, 0.2682g (0.72mmol) CeCl 3 ·7H 2 O, 0.0896g (0.24

[0030] mmol)TbCl 3 ·6H 2 O was dissolved in a beaker by adding 3.2mL, 3.6mL, and 1.2mL of deionized water respectively, and the obtained solutions were successively added into a three-necked flask (stirring while adding), and 32mL of deionized water was added into the three-necked flask, and fully stirred. Add 10 mL of NH to the mixed solution 4 F solution (0.222gNH 4 F, 10mL deionized water), heated to 70°C, kept for 2h, and kept stirring during the reaction. After the reaction, the obtained sample was centrifuged, washed with water, and stored at room temperature.

[0031] Add chitosan to 0.25% (V / V) acetic acid solution to make 200mL of 0.25% (W / V) chitosan acetic acid solution, add it to a 500mL three-necked flask, ultrasonicate and nitrogen gas for 30min, add 44mL iron Solution (FeCl 3 ·6H 2 O 7.2g, FeCl 2 4H 2 O 2.92g) and stirred for 1h, at 40°C, slowly added ...

Embodiment 2

[0035]Weigh 0.7056g (0.0019mol) LaCl 3 ?7H 2 O, 0.6963g (0.0019mol) EuCl 3 ?6H 2 O was dissolved in a beaker by adding 25 mL of deionized water, transferred to a three-neck flask, and stirred for 5 min. Then add 10mLNH 4 F solution (0.2109gNH 4 F, 10mL deionized water), and the mixture was heated to 75°C for 2h and kept stirring during the reaction. After the reaction, the obtained sample was centrifuged, washed with water, and stored at room temperature.

[0036] Add chitosan to 0.25% (V / V) acetic acid solution to make 200mL of 0.25% (W / V) chitosan acetic acid solution, add it to a 500mL three-necked flask, ultrasonicate and nitrogen gas for 30min, add 44mL iron Solution (FeCl 3 ·6H 2 O 7.2g, FeCl 2 4H 2 O 2.92g) and stirred for 1h, at 40°C, slowly added 40mL of 28% ammonia water dropwise, stirred rapidly, after reacting for 20min, raised the temperature to 60°C, added dropwise 6.6mL of epichlorohydrin, reacted for 5h, cooled, washed with water until neutral, and wa...

Embodiment 3

[0039] Weigh 0.1857g (0.50mmol) LaCl 3 ·7H 2 O, 0.3576g (0.96mmol) CeCl 3 ·7H 2 O, 0.0523g (0.14

[0040] mmol)TbCl 3 ·6H 2 O was dissolved in a beaker by adding 3.2mL, 3.6mL, and 1.2mL of deionized water respectively, and the obtained solutions were successively added into a three-necked flask (stirring while adding), and 32mL of deionized water was added into the three-necked flask, and fully stirred. Add 10 mL of NH to the mixed solution 4 F solution (0.222gNH 4 F, 10mL deionized water), heated to 70°C, kept for 2h, and kept stirring during the reaction. After the reaction, the obtained sample was centrifuged, washed with water, and stored at room temperature.

[0041] Add chitosan to 0.25% (V / V) acetic acid solution to make 200mL of 0.25% (W / V) chitosan acetic acid solution, add it to a 500mL three-necked flask, ultrasonicate and nitrogen gas for 30min, add 44mL iron Solution (FeCl 3 ·6H 2 O 0.72g, FeCl 2 4H 2 O 0.29g) and stirred for 1h, at 40°C, slowly added...

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Abstract

The invention relates to magnetic chitosan / doped rare earth compound particles and a preparation method thereof. The composition of the magnetic chitosan / doped rare earth compound particles is that: the weight ratio of chitosan to Fe3O4 (based on Fe) is 20:1-1:5; the weight ratio of doped rare earth compounds (based on La) to the chitosan is 2:100-50:100; and the doped rare earth compounds are LaF3-doped Eu as well as LaF3-doped Ce<3+> and Tb<3+> respectively. The preparation method comprises the following steps of: preparing magnetic chitosan (Fe3O4 / CS) and the doped rare earth compounds respectively; and preparing the magnetic chitosan / doped rare earth compound particles through ionic crosslinking by a reverse microemulsion method. The preparation method is simple. The obtained compound particles have better magnetic responsiveness and fluorescent characteristics, high biocompatibility, and low toxicity, can be used as a multi-functional biomarker probe in nuclear magnetic resonance imaging and fluorescence imaging, and are widely applied to the fields of targeted medicines, enzyme immobilization, biomolecular determination, cellular segregation and the like.

Description

technical field [0001] The invention relates to magnetic chitosan / doped rare earth composite particles and a preparation method thereof, belonging to the field of biomarkers. Background technique [0002] Multifunctional nanoparticles with good magnetic responsiveness and fluorescence properties have broad application prospects in the fields of targeted drugs, enzyme immobilization, biomolecular determination, cell separation, nuclear magnetic resonance imaging and fluorescence imaging. research hotspots. It has been reported that Fe 3 o 4 -Quantum dots, Fe 3 o 4 -Organic dyes, Fe 3 o 4 - Composite particles such as rare earth, generally Fe is prepared first 3 o 4 and quantum dots and other nanoparticles, and then use SiO 2 Or coated with polymer materials, and then introduce active groups through chemical reactions in the coating layer for modification, improve its biocompatibility, and connect with other substances. [0003] Rare earth-doped luminescent nanopar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08K3/22C08K3/16C08K3/32C08J3/24A61K47/36A61K47/02A61K49/00A61K49/12A61K49/18
Inventor 肖玲涂家薇李晓玲
Owner WUHAN UNIV
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