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Preparation method of paederia scandens glucoside

A kind of technology of Galloside and Gallanthin, which is applied in the field of medicine and achieves the effects of low cost, reduced energy consumption and good effect.

Inactive Publication Date: 2012-02-08
苏州宝泽堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are few relevant reports on the extraction process of gallinacein

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 1kg of the medicinal material of Gallus chinensis, crush it, add 12 times the amount of distilled water for microwave extraction twice, each time for 0.5h, and the microwave power is 700w, filter to obtain the extract, add HZ806 macroporous resin column for adsorption, and first elute with distilled water to The column solution is colorless, and then eluted with 7BV60% ethanol solution to obtain the eluate, which is concentrated until it has no alcohol smell, added to a polyamide column, eluted with distilled water and 30% ethanol in turn, collected the eluate, and concentrated to a small volume , place the crystals, filter out the crystals, reflux with ethanol to dissolve, add petroleum ether dropwise to recrystallize, filter out and dry in vacuum at low temperature to obtain 2.1 g of gallizine, the content of which is 84.6% by high-phase liquid phase detection.

[0020]

Embodiment 2

[0022] Take 1kg of the medicinal material of Chickweed, crush it, add 10 times the amount of distilled water for microwave extraction twice, each time for 2 hours, and the microwave power is 300w, filter to obtain the extract, add D101 macroporous resin column for adsorption, and first elute with distilled water to the bottom The column liquid was colorless, and then eluted with 4BV40% ethanol solution to obtain the eluate, which was concentrated until it had no alcohol smell, added to a polyamide column, eluted with distilled water and 30% ethanol in turn, collected the eluate, concentrated to a small volume, Place the crystals on place, filter out the crystals, dissolve them under reflux with ethanol, add petroleum ether dropwise to recrystallize, filter out and dry in vacuum at low temperature to obtain 1.9 g of gallinacein, the content of which was 85.7% as detected by the high-phase liquid phase.

[0023]

Embodiment 3

[0025] Take 2kg of the medicinal material of Gallus chinensis, crush it, add 12 times the amount of distilled water for microwave extraction twice, each time for 0.5h, and the microwave power is 500w, filter to obtain the extract, add S-8 macroporous resin column for adsorption, and wash with distilled water first Remove until the column liquid is colorless, then elute with 4BV50% ethanol solution to obtain the eluate, concentrate until it has no alcohol smell, add it to a polyamide column, elute with distilled water and 30% ethanol successively, collect the eluate, and concentrate to Small volume, place the crystals, filter out the crystals, reflux with ethanol to dissolve, add petroleum ether dropwise to recrystallize, filter out and vacuum dry at low temperature to obtain 4.3g of gallinacein, the content of which is 88.1% by high-phase liquid phase detection.

[0026]

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PUM

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Abstract

The invention relates to a preparation method of paederia scandens glucoside. Paederia scandens is used as a raw material and is crushed, distilled water is added for microwave extraction, and the extract is purified through macroporous resin, then is separated through polyamide columns and is recrystallized to obtain a paederia scandens glucoside product. The method disclosed by the invention has the advantages of large preparation amount and high product purity, the adopted macroporous resin and the polyamide columns can used repeatedly, and the cost is low.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a preparation method of gallizine. Background technique [0002] Glycyrrhizae is the whole herb and root of the perennial herbaceous vine of the genus Glycyrrhizae of Rubiaceae. It has the effects of expelling wind and dampness, digesting food and accumulation, detoxifying and reducing swelling, promoting blood circulation and relieving pain. Indications for infantile malnutrition, diarrhea, dysentery, heatstroke, jaundice, hepatitis, hepatosplenomegaly, cough, scrofula, intestinal fistula, unknown swelling, wet and swollen feet, burns, eczema, dermatitis, bruises, snakes Scorpion sting embolism. As a traditional folk herbal medicine and food, Gallus chinensis has a long history of thousands of years, especially in the treatment of toothache, chest pain, pain caused by hemorrhoids, rheumatoid arthritis, spleen inflammation and bacillary dysentery. [0003] Galloside contains iri...

Claims

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Application Information

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IPC IPC(8): C07H17/04C07H1/08
Inventor 李法庆刘东锋
Owner 苏州宝泽堂医药科技有限公司
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