Preparation method and application of astragalus polysaccharide-calcium complex

A technology of astragalus polysaccharides and complexes, applied in the field of medicine, can solve the problems of poor water solubility, low absorption rate of calcium supplementation, and affecting the effect of taking, and achieve the effect of high absorption rate and good water solubility

Inactive Publication Date: 2012-02-15
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of the above situation, in order to overcome the deficiencies of the prior art, the purpose of the present invention is to provide a preparation method and application of astragalus polysaccharide calcium complex, which can effectively solve the problems of poor water solubility, low absorption rate of calcium supplementation, and affecting the effect of taking

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] In concrete implementation, the present invention is realized by the following steps:

[0012] (1) Preparation of astragalus polysaccharide solution: take 100 g of dried astragalus membranaceus, crush it, add 2000 mL of distilled water to each 100 g of astragalus membranaceus powder, extract 3 times at 85 ° C for 5 hours each time, filter to remove residues, and combine the filtrates to obtain astragalus polysaccharide solution;

[0013] (2) Preparation of CaCl 2 Ionic solution and NaOH ionic solution: CaCl 2 Add water to prepare CaCl with a concentration of 2mol / L 2 Ionic solution; add NaOH to water to prepare a NaOH ion solution with a concentration of 2mol / L;

[0014] (3) Complexation reaction: Add CaCl with a concentration of 2 mol / L prepared in step (2) dropwise to the astragalus polysaccharide solution prepared in step (1) 2 Ion solution 100mL, stirring while dropping, at the same time dropwise adding the NaOH ion solution with a concentration of 2mol / L prepare...

Embodiment 2

[0016] The present invention can also be realized by the following methods in implementation:

[0017] The procedure is the same as that in Example 1. Take 200 g of dried coarse powder of Astragalus membranaceus, add 3000 mL of water, extract 3 times in a water bath at 89 ° C, 6 hours each time, filter to remove the residue, combine the filtrates, and add 2 mol / L of CaCl 2 solution, adjust the pH value to 10 with 2mol / L NaOH solution, and place it at room temperature for 9 hours to obtain the astragalus polysaccharide calcium complex solution. Dialysis to obtain dialysate, or use nanofiltration device to concentrate and filter the astragalus polysaccharide calcium complex solution to obtain the filtrate after removing small molecules, and add mass concentration of 95% ethanol to the dialysate or the filtrate after removing small molecules The ethanol content reaches 82%, and it is allowed to stand for 18 hours. After filtering or centrifuging, the precipitate is obtained. Afte...

Embodiment 3

[0019] The present invention also is realized by following method in implementation:

[0020] Prepare according to the steps of Example 1, wherein the raw material is 50 g of Radix Astragali, add 1500 mL of water, extract twice in a water bath at 95 ° C, 7 hours each time, filter to remove the residue, combine the filtrates, and add 2 mol / L of CaCl 2 solution, and simultaneously add 2mol / L NaOH solution to adjust the pH value to 11, stir for 1 hour, and place it at room temperature for 13 hours to obtain the astragalus polysaccharide calcium complex solution, and the obtained astragalus polysaccharide calcium complex solution has a molecular weight cut-off of 8000 -14000 dialysis bag for dialysis to obtain dialysate, or use nanofiltration device to concentrate and filter astragalus polysaccharide calcium complex solution to obtain filtrate after removing small molecules, add mass concentration to dialysate or filtrate after removing small molecules 95% ethanol until the ethano...

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Abstract

The invention relates to a preparation method and application of an astragalus polysaccharide-calcium complex, and can solve the problems of poor water solubility, low calcium supplement absorptivity and influence on eating effects. The method comprises the steps of: adding astragalus medicinal material into water for extraction, and conducting filtration so as to obtain an astragalus polysaccharide solution; adding a CaCl2 ion solution drop by drop into the astragalus polysaccharide solution under stirring till saturation, and simultaneously adding a NaOH ion solution for complex reaction till the pH value of the solution in the range of 9-11, standing and stirring the solution for 0.5-2h, thus obtaining a astragalus polysaccharide-calcium complex solution, then carrying out dialysis with a dialysis bag or condensation and filtration, then adding ethanol of 95% in mass concentration till the ethanol content up to 80-85%, standing the solution for 8-24h, carrying out filtration or centrifugation so as to obtain a sediment, which is then dried and crushed into particles, i.e. the astragalus polysaccharide-calcium complex. The complex of the invention has good water solubility and high absorptivity, thus being a major innovation in traditional Chinese medicine.

Description

technical field [0001] The invention relates to medicine, in particular to a preparation method and application of astragalus polysaccharide calcium complex. Background technique [0002] Polysaccharides are natural polymers formed by glycosidic condensation of aldose and ketose. They are widely found in higher plants, algae, and microorganisms. They are the basic components of biological organisms and are closely related to many important functions of sustaining life. Astragalus polysaccharide can be used as an immune booster or regulator, and has anti-virus, anti-tumor, anti-aging, anti-radiation, anti-stress, and anti-oxidation effects. At present, the calcium source absorption form of common calcium supplement products on the market is mostly ionized calcium. Calcium ions tend to react with other anions in the gastrointestinal tract of the human body, resulting in precipitation and poor water solubility, which reduces the concentration of calcium ions, affecting absorpti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P19/10A61P37/04A61P25/00
Inventor 刘富岗杨云
Owner HENAN UNIV OF CHINESE MEDICINE
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