Application of alginate oligosaccharide to preparation of medicament for facilitating postnatal uterine contraction

A technology of alginate oligosaccharide and uterine contraction, which is applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve the problems of unreported uterine contraction effect and the like

Inactive Publication Date: 2012-03-14
QINGDAO UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Alginate oligosaccharides have been reported in terms of hemostasis (see CN12

Method used

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  • Application of alginate oligosaccharide to preparation of medicament for facilitating postnatal uterine contraction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Effect of Alginate Oligosaccharides on Uterine Contraction of Isolated Mice

[0014] Preparation of isolated mouse uteri: 2 days before the experiment, non-pregnant female mice were injected intraperitoneally with diethylstilbestrol every day to increase the sensitivity of the uterus to drugs; the mice were killed quickly by cervical dislocation, and the uterus was removed by laparotomy to make a length of about 1.0cm. uterine smooth muscle strips. Put the uterus ligated with silk thread into a Maxwellian bath filled with 20ml, fix one end of the silk thread ligated to the specimen fixing hook in the bath, and connect the other end to the tension transducer, and give the uterus a load of 1g. After the uterine contraction is stable, the normal contraction curve is recorded. For each group, the motherwort aqueous solution (the concentration is expressed by the amount of crude drug contained in each milliliter of the solution) and various concentrations of algi...

Embodiment 2

[0018] Example 2: Acute Toxicity Study of Alginate Oligosaccharide Extract

[0019] Take alginate oligosaccharides at 900mg / 20g (1000 times greater than the clinical dosage) to 30 Kunming female mice (body weight 18-22g) orally, for 7 consecutive days, and observe the acute toxicity of the mice. Results: There was little difference in normal body weight, none of them died, and no obvious pathological damage was found by naked eye autopsy after execution.

Embodiment 3

[0020] Embodiment 3: the preparation of alginate oligosaccharide tablet

[0021] prescription:

[0022] Alginate oligosaccharides 100mg

[0023] Lactose 100mg

[0024] Starch 295mg

[0025] Magnesium Stearate 5mg

[0026] Total 500mg

[0027] Weigh out the main ingredients respectively, mix alginate oligosaccharide powder through 80-mesh sieve, lactose, and starch, granulate by wet method, dry, mix with magnesium stearate after integration, press into tablets, and press into 500mg per tablet tablet.

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Abstract

The invention discloses application of an alginate oligosaccharide to the preparation of a medicament for facilitating postnatal uterine contraction. The alginate oligosaccharide is obtained by oxidizing and degrading polysaccharide alginate extracted from kelp, and the viscosity is 1-20 cps. The alginate oligosaccharide has the effect of forcibly contracting the uterus, can be prepared into a plurality of dosage forms, is suitable for facilitating postnatal uterine contraction, is used for treating postnatal hemorrhage, postnatal infection as well as subinvolution after medical abortion and induced abortion, and has the advantages and characteristics of remarkable curative effect, low price, safety, convenience and no side effect.

Description

technical field [0001] The present invention relates to the application of marine active substance alginate oligosaccharide in the preparation of medicine for uterine contraction. Background technique [0002] Alginate is a general term for alginic acid and salts (sodium alginate, potassium alginate), which is a natural substance extracted from kelp, wild brown algae Sargassum, wakame, hijiki, kelp, ascophyllum and other algae High molecular polysaccharide polymer. Alginate has been widely used in medicine, food, chemical industry and other fields, and several patents have disclosed its extraction and production process. The inventors have proved that alginate is more active at low molecular weight. In this paper, alginate is oxidized and degraded by an oxidizing agent to obtain alginate oligosaccharides with a viscosity of 1-20 cps. Alginate oligosaccharides have been reported in terms of hemostasis (see CN1280828A), but the effect of promoting uterine contraction has not...

Claims

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Application Information

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IPC IPC(8): A61K31/702A61P15/04
Inventor 岳旺石振艳杨志宏李静
Owner QINGDAO UNIV
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