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Olive effervescent tablet and preparation method thereof

A technology for effervescent tablets and olives, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of rare curative effect drugs, etc., and achieves improved drug bioavailability, significant curative effect, and disintegration. quick effect

Inactive Publication Date: 2012-03-21
FUJIAN ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, there are few specific drugs with significant curative effect and convenient use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The raw materials of olive effervescent tablet and the mass parts of each raw material: 2 parts of olive, 2 parts of loquat flower, 1 part of grass coral, and 1 part of Luo Han Guo. The concrete steps of its preparation method are as follows:

[0023] (1) Weigh olives, loquat flowers, grass corals, and Luo Han Guo according to the ratio of raw materials, mix and grind them, add ethanol with the same total weight of raw materials, and conduct CO 2 Supercritical extraction for 2 hours to obtain the Chinese medicine extract;

[0024] (2) Take the traditional Chinese medicine extract obtained in step (1), add lactose and starch of the same weight, dry at 60°C for 2 hours, pulverize into 180-mesh fine powder, divide into 2 parts on average, and set aside; the weight ratio of lactose and starch is 3:2;

[0025] (3) Take 1 part of the fine powder obtained in step (2), add citric acid 0.5 times its weight, use starch slurry with a mass fraction of 10% as a binder, granulate w...

Embodiment 2

[0029] The raw materials of the olive effervescent tablet and the mass parts of each raw material are: 6 parts of olive, 6 parts of loquat flower, 5 parts of grass coral, and 3 parts of Luo Han Guo. The concrete steps of its preparation method are as follows:

[0030] (1) Weigh olives, loquat flowers, grass corals, and Luo Han Guo according to the ratio of raw materials, mix and grind them, add ethanol 3 times the total weight of raw materials, and conduct CO 2 Supercritical extraction for 4 hours to obtain the Chinese medicine extract;

[0031] (2) Take the traditional Chinese medicine extract obtained in step (1), add lactose and starch twice its weight, dry at 70°C for 3 hours, grind it into 220-mesh fine powder, divide it into 2 parts on average, and set aside; the lactose and starch The weight ratio is 3:2;

[0032] (3) Take 1 part of the fine powder obtained in step (2), add citric acid 1.5 times its weight, use starch slurry with a mass fraction of 15% as a binder, gr...

Embodiment 3

[0036] The raw materials of olive effervescent tablet and the mass parts of each raw material: 2 parts of olive, 3 parts of loquat flower, 4 parts of grass coral, and 2 parts of Luo Han Guo. The concrete steps of its preparation method are as follows:

[0037] (1) Weigh olives, loquat flowers, grass corals, and Luo Han Guo according to the ratio of raw materials, mix and grind them, add ethanol twice the total weight of raw materials, and conduct CO at 45°C and 35MPa. 2 Supercritical extraction for 3 hours to obtain the Chinese medicine extract;

[0038] (2) Take the traditional Chinese medicine extract obtained in step (1), add lactose and starch 1-2 times its weight, dry at 65°C for 2.5 hours, pulverize into 200-mesh fine powder, divide it into 2 parts on average, and set aside; the lactose The weight ratio with starch is 3:2;

[0039] (3) Take 1 portion of the fine powder obtained in step (2), add the same weight of citric acid, use starch slurry with a mass fraction of 1...

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Abstract

The invention discloses an olive effervescent tablet and a preparation method thereof. The effervescent tablet is prepared from the following raw materials in parts by weight: 2 to 6 parts of olive, 2 to 6 parts of loquat flower, 1 to 5 parts of sarcandra glabra, and 1 to 3 parts of siraitia grosvenorii. The olive effervescent tablet prepared by the method has the functions of clearing and moistening laryngopharynx, soothing chest and nourishing lung, and diminishing swelling and relieving pain; the tablet performs acid base reactions in water before administration and is disintegrated quickly, so that the bioavailability of the medicament is improved, the color and smell can be regulated flexibly. The olive effervescent tablet is suitable for various people, in particular children, old people and patients being incapable of swallowing.

Description

technical field [0001] The invention relates to a throat-clearing and throat-clearing product, in particular to an olive effervescent tablet and a preparation method thereof. Background technique [0002] Pharyngitis is a kind of common disease, can be divided into acute and chronic two big classes according to the course of disease, motherland's medical science is collectively referred to as " sore throat ". [0003] The pharynx is the main channel for the human body to communicate with the outside world, and has important functions such as defense, breathing, swallowing, and vocal resonance. The pathological changes caused by acute and chronic inflammation of the pharynx not only cause local dysfunction of the pharynx, but also affect adjacent organs and tissues, and even affect other systems in the whole body. It is a common and frequently-occurring disease that endangers human health. Occupational diseases in the industry. According to clinical reports, its incidence a...

Claims

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Application Information

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IPC IPC(8): A61K36/42A61K9/46A61P11/04
Inventor 张亚敏徐榕青林文津
Owner FUJIAN ACAD OF MEDICAL SCI
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