Method for detecting whether patient is allergic to medicine

Abstract

The invention discloses a method for detecting whether a patient is allergic to a medicine, which comprises the following steps: 1) dissolving a possibly allergic medicine to be detected, which is used as a solute, in a solvent to prepare a detection agent of which the concentration is 5-40%; and 2) carrying out allergy testing on a patient by using the obtained agent according to the medicine patch test. The possibly allergic medicine to be detected is an antitubercular agent, and a solvent is vaseline or water. The method can obviously enhance the transdermal absorptivity of the medicine. The clinical verification and in-vitro experimentation prove that the anaphylaxis of the medicine patch test is up to 68.7%, the specificity is up to 82.5%, and all cases do not have systemic adverse reaction.

Description

technical field [0001] The invention relates to a method for detecting whether a patient is allergic to drugs, and the method is specially aimed at detecting whether the patients are allergic to four common drugs in anti-tuberculosis drugs. [0002] Background technique [0003] Drug allergy is a common but unpredictable medical phenomenon. Many commonly used drugs, such as antipyretic analgesics, antibiotics, antihypertensive drugs, hypoglycemic drugs, anticonvulsants, etc., can cause damage to the skin and multiple organs, and even endanger life. Delayed drug allergy accounts for more than 80% of all drug allergies. The incubation period varies, and drug combinations are often used. Coupled with the interference of environmental factors, it is difficult to determine the sensitizing drug. At present, the determination of allergenic drugs mainly relies on the review and analysis of medical history, lacking specific detection methods. [0004] Judging from the current domes...

AI Technical Summary

Problems solved by technology

However, due to the low sensitivity of this method, the lack of standard operating methods and large-scale clinical verification, it has not been used in clinical practice, and there is no commercial kit for sale.

Moreover, the existing practical drug patch test is mainly aimed at the detection of chemical reagents and metal substance allergies, and there is no clinical application for drug allergies.

At present, only penicillin is the only drug that can be tested for allergies in medicine. The determination of other allergenic drugs mainly depends on the review and analysis of medical history, and there is no special testing method