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Method for detecting whether patient is allergic to medicine

A drug and allergy technology, applied in the field of detecting whether a patient is allergic to drugs, can solve the problems of lack of standard operating methods for large-sample clinical verification, low sensitivity, and no commercial kits for sale.

Inactive Publication Date: 2012-03-21
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the low sensitivity of this method, the lack of standard operating methods and large-scale clinical verification, it has not been used in clinical practice, and there is no commercial kit for sale.
Moreover, the existing practical drug patch test is mainly aimed at the detection of chemical reagents and metal substance allergies, and there is no clinical application for drug allergies.
At present, only penicillin is the only drug that can be tested for allergies in medicine. The determination of other allergenic drugs mainly depends on the review and analysis of medical history, and there is no special testing method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0023] A 27-year-old male was taking quadruple anti-tuberculosis therapy of rifampicin, isoniazid, pyrazinamide and ethambutol for left upper pulmonary tuberculosis. Two weeks after taking the medicine, measles-like erythema appeared on the trunk and extremities, accompanied by obvious itching. After being diagnosed as "drug eruption", all drugs were stopped and the rash subsided after 1 week of antiallergic treatment. According to this method, it was confirmed by drug skin patch test that among the four drugs, they were allergic to rifampicin. After taking isoniazid, pyrazinamide and ethambutol to continue anti-tuberculosis treatment, no rash appeared again.

[0024] case two

[0025] Female, 44 years old, took rifampicin, isoniazid, pyrazinamide, ethambutol anti-tuberculosis treatment for tuberculous pleurisy. One month after taking the medicine, measles-like erythema appeared on the trunk and extremities, and later developed into erythroderma with abnormal liver function...

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PUM

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Abstract

The invention discloses a method for detecting whether a patient is allergic to a medicine, which comprises the following steps: 1) dissolving a possibly allergic medicine to be detected, which is used as a solute, in a solvent to prepare a detection agent of which the concentration is 5-40%; and 2) carrying out allergy testing on a patient by using the obtained agent according to the medicine patch test. The possibly allergic medicine to be detected is an antitubercular agent, and a solvent is vaseline or water. The method can obviously enhance the transdermal absorptivity of the medicine. The clinical verification and in-vitro experimentation prove that the anaphylaxis of the medicine patch test is up to 68.7%, the specificity is up to 82.5%, and all cases do not have systemic adverse reaction.

Description

technical field [0001] The invention relates to a method for detecting whether a patient is allergic to drugs, and the method is specially aimed at detecting whether the patients are allergic to four common drugs in anti-tuberculosis drugs. [0002] Background technique [0003] Drug allergy is a common but unpredictable medical phenomenon. Many commonly used drugs, such as antipyretic analgesics, antibiotics, antihypertensive drugs, hypoglycemic drugs, anticonvulsants, etc., can cause damage to the skin and multiple organs, and even endanger life. Delayed drug allergy accounts for more than 80% of all drug allergies. The incubation period varies, and drug combinations are often used. Coupled with the interference of environmental factors, it is difficult to determine the sensitizing drug. At present, the determination of allergenic drugs mainly relies on the review and analysis of medical history, lacking specific detection methods. [0004] Judging from the current domes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
Inventor 钟华宋志强郝飞
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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