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Polyacrylic resin I and preparation method thereof

A technology of polyacrylic acid resin and methacrylic acid, which is applied in the direction of pharmaceutical formulations and medical preparations of non-active ingredients, etc. It can solve the problems of easy-to-freeze products, inconvenient storage, poor film-forming solubility, etc., and achieve good release effect and convenient Easy to store and use

Active Publication Date: 2013-08-21
张绍国
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Due to the unreasonable formula of the polymer components, the latex product in the prior art has poor film-forming solubility, resulting in insufficient dissolution of the wrapped substance; at the same time, the latex is a liquid product, which is inconvenient to store, easy to mildew, and easy to freeze The product deteriorates, and the liquid product is inconvenient to transport; in addition, the limitation of the use of the latex product is that it cannot be used as a water dispersion for coating like a solid powder product, and it can also be fully mixed with raw materials and other auxiliary materials as a skeleton material for compression. tablet use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1, a kind of polyacrylic acid resin I, it is made by the raw material of following weight ratio:

[0024] Methacrylic acid 100; Ethyl acrylate 18;

[0025] Butyl acrylate 69; Potassium persulfate or ammonium persulfate 0.336;

[0026] Nonoxynyl alcohol 10 0.019; Sodium lauryl sulfate 0.729;

[0027] Tween 80 2.917; Purified water 438;

[0028] Prepared according to conventional methods of the prior art.

Embodiment 2

[0029] Embodiment 2, a kind of polyacrylic acid resin I, it is made by the raw material of following weight ratio:

[0030] Methacrylic acid 100; Ethyl acrylate 26;

[0031] Butyl acrylate 87; Potassium persulfate or ammonium persulfate 0.660;

[0032] Nonoxynyl alcohol 10 0.064; Sodium lauryl sulfate 1.512;

[0033] Tween 80 4.963; Purified water 526;

[0034] The preparation method step of described polyacrylic acid resin I is as follows:

[0035] (1) Add purified water, potassium persulfate or ammonium persulfate, nonoxynol 10, sodium lauryl sulfate and Tween 80 weighed according to the weight ratio into the reactor; stir the reactor, and The reaction kettle is heated up to 60°C;

[0036] (2) Mix methacrylic acid, ethyl acrylate, and butyl acrylate weighed according to the weight ratio into the high-level tank, and then drop them into the reaction kettle; 30 minutes; after cooling, carry out spray drying to obtain polyacrylic acid resin I powder.

Embodiment 3

[0037] Embodiment 3, a kind of polyacrylic acid resin I, it is made by the raw material of following weight ratio:

[0038] Methacrylic acid 100; Ethyl acrylate 22;

[0039] Butyl acrylate 78; Potassium persulfate 0.496;

[0040] Nonoxynol 10 0.041; Sodium Lauryl Sulfate 1.121;

[0041] Tween 80 3.940; Purified water 482;

[0042] The preparation method step of described polyacrylic acid resin I is as follows:

[0043] (1) Add purified water, potassium persulfate, nonoxynol 10, sodium lauryl sulfate and Tween 80 weighed according to the weight ratio into the reactor; stir the reactor, and heat the reactor to 90°C;

[0044] (2) Mix methacrylic acid, ethyl acrylate, and butyl acrylate weighed according to the weight ratio into the high-level tank, and then drop them into the reactor; after the addition is completed, control the temperature of the reactor at 105°C and continue 60 minutes; after cooling, carry out spray drying to obtain polyacrylic acid resin I powder.

[00...

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PUM

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Abstract

The invention discloses polyacrylic resin I. The polyacrylic resin I is characterized by comprising 100 parts by weight of methacrylic acid, 18 to 26 parts by weight of ethyl acrylate, 69 to 87 parts by weight of butyl acrylate, 0.336 to 0.660 parts by weight of potassium persulphate or ammonium persulfate, 100.019 to 0.064 parts by weight of nonoxynol, 0.729 to 1.512 parts by weight of sodium dodecyl sulfate, 802.917 to 4.963 parts by weight of tween and 438 to 526 parts by weight of purified water. The invention also relates to a preparation method of the polyacrylic resin I. The polyacrylic resin I can be utilized as an enteric coating material of a pharmaceutic solid preparation, also can be utilized as a sustained-release framework material of a solid preparation, is convenient for use, and has good release effects.

Description

technical field [0001] The present invention relates to a pharmaceutical excipient, especially a polyacrylic acid resin I; the present invention also relates to a preparation method of the polyacrylic acid resin I. Background technique [0002] Due to the unreasonable formula of the polymer components, the latex product in the prior art has poor film-forming solubility, resulting in insufficient dissolution of the wrapped substance; at the same time, the latex is a liquid product, which is inconvenient to store, easy to mildew, and easy to freeze The product deteriorates, and the liquid product is inconvenient to transport; in addition, the limitation of the use of the latex product is that it cannot be used as a water dispersion for coating like a solid powder product, and it can also be fully mixed with raw materials and other auxiliary materials as a skeleton material for compression. tablet use. Contents of the invention [0003] The technical problem to be solved by ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/06C08F220/18C08F2/30A61K47/32
Inventor 张绍国
Owner 张绍国
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