Method for extracting chlorogenic acid from honeysuckle flower leaves
A technology of honeysuckle leaves and chlorogenic acid, which is applied in chemical instruments and methods, separation/purification of carboxylate, preparation of carboxylate, etc. It can solve the problems of ignoring extraction and wasting effective resources, so as to improve purity and reduce production Cost, increase the effect of economic benefits
Inactive Publication Date: 2012-03-28
重庆市秀山红星中药材开发有限公司
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[0002] Honeysuckle belongs to Lonicera, and the whole plant can be used as medicine. The buds contain volatile aromatic oils, inositol, saponins, chlorogenic acid, flavonoids, cinnamic acid, nerolidol, jasmonal, etc. The stems contain alkaloids. It contains honeysuckle and luteolin, etc. It is one of the traditional Chinese medicinal materials, and it is also a raw material for both medicine and food. It has the effects of clearing away heat and detoxifying, cooling wind and heat, protecting the liver and promoting gallbladder. It has been used in the field of traditional Chinese medicine for carbuncles and boils. , sore throat, erysipelas, pyretic blood dysentery, wind-heat cold, and treatment of warm-heat diseases; especially honeysuckle buds, stems, and leaves contain chlorogenic acid, which can prevent and treat upper respiratory tract infections, wind-heat cold and It has a good effect on gastrointestinal diseases, and has a good effect on scavenging free radicals, delaying aging, and improving human immune function; therefore, the extraction of chlorogenic acid is an important topic in the pharmaceutical field. Most of the traditional chlorogenic acid extraction processes only The extraction of chlorogenic acid ignores the extraction of chlorogenic acid in stems and leaves, which seriously wastes effective resources
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[0017] The present invention will be further described below in conjunction with embodiment.
[0018] Grind 10kg of dried honeysuckle leaves after rough processing, and pass through a No. 4 sieve; then soak the powder in 100L ethanol solution, the ethanol concentration is 70%, and the soaking time is 50min, filter to obtain the extract, and leave the filter residue; then add the filter residue to The concentration is 110L of 70% ethanol, soak for 40min, filter to obtain the extract, and leave the filter residue; then add the second filter residue to 90L of 70% ethanol, soak for 35min, filter to obtain the extract; then combine the three extracts for use.
[0019] Add a clarifier to the extract, stir it well and let it stand for 12 hours, separate the supernatant and sediment, and then filter to obtain the supernatant filtrate; then use a macroporous resin with a particle size of 0.8mm to adsorb the supernatant Clear liquid filtrate, the flow rate is 500L / hr; then elute with pu...
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The invention relates to a method for extracting chlorogenic acid from honeysuckle flower leaves. The method comprises the following steps of: crushing, soaking, filtering, eluting, concentrating, drying, packaging in separate bags and the like. By the method, effective resources are utilized to a maximum limit, economic benefit is increased, food grade ethanol is used as an extractant and a purifying agent in the production process, and the chlorogenic acid is extracted at normal temperature, so the production cost is reduced, and the chlorogenic acid is prevented from being decomposed; the honeysuckle flower leaves are soaked for multiple times in the soaking process, and extraction solution is obtained, so the purity is improved effectively; and purification and elution are performed by using macroporous resin, so that the purity of the chlorogenic acid is improved greatly to 35 to 95 percent according to requirements.
Description
technical field [0001] The invention relates to a method for extracting chlorogenic acid, in particular to a method for extracting chlorogenic acid from honeysuckle leaves. Background technique [0002] Honeysuckle belongs to Lonicera, and the whole plant can be used as medicine. The buds contain volatile aromatic oils, inositol, saponins, chlorogenic acid, flavonoids, cinnamic acid, nerolidol, jasmonal, etc. The stems contain alkaloids. It contains honeysuckle and luteolin, etc. It is one of the traditional Chinese medicinal materials, and it is also a raw material for both medicine and food. It has the effects of clearing away heat and detoxifying, cooling wind and heat, protecting the liver and promoting gallbladder. It has been used in the field of traditional Chinese medicine for carbuncles and boils. , sore throat, erysipelas, pyretic blood dysentery, wind-heat cold, and treatment of warm-heat diseases; especially honeysuckle buds, stems, and leaves contain chlorogenic...
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IPC IPC(8): C07C69/732C07C67/48C07C67/56
Inventor 祝利赵勇彪杨再江向延军何全慧
Owner 重庆市秀山红星中药材开发有限公司