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Esomeprazole-containing medicinal composition

A technology of esomeprazole and composition, applied in the field of pharmaceutical composition containing esomeprazole, to achieve the effects of prolonging the action time, short course of treatment, and few adverse reactions

Inactive Publication Date: 2012-04-04
CHENGDU XINJIE HIGH TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Because esomeprazole magnesium is unstable in an acidic environment, the previously marketed esomeprazole magnesium preparations are enteric-coated preparations, which are coated with an enteric coating to protect the drug from acid degradation, but it delays the absorption of the drug and initial inhibition of gastric acid

Method used

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  • Esomeprazole-containing medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Element Composition 1 Composition 2 Composition 3 Esomeprazole Sodium 20 copies 30 copies 40 copies sodium bicarbonate 1100 copies 1150 copies 1200 copies

[0034] According to the preparation of the above-mentioned components, mix them in the stated ratio, and prepare tablets according to the prior art.

Embodiment 2

[0036] Element Composition 4 Composition 5 Composition 6 Esomeprazole Magnesium 20 copies 30 copies 40 copies sodium bicarbonate 1150 copies 1165 copies 1180 copies

[0037] According to the preparation of the above-mentioned components, mix them in the stated ratio, and prepare tablets according to the prior art. Sodium bicarbonate in the table can also be replaced by calcium carbonate.

Embodiment 3

[0039] Element Composition 7 Composition 8 Composition 9 Esomeprazole Magnesium 20 copies 30 copies 40 copies sodium bicarbonate 710 copies 750 copies 800 copies magnesium hydroxide 400 copies 420 copies 400 copies

[0040] According to the preparation of the above-mentioned components, mix them in the stated ratio, and prepare tablets according to the prior art.

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PUM

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Abstract

The invention discloses an esomeprazole-containing medicinal composition, which contains esomeprazole and a buffering agent. The problem that an esomeprazole magnesium enteric preparation is slowly absorbed is solved through the medicinal composition; and the medicinal composition is convenient to takeeat, is takeneaten for only one time everyday when a patient is in an empty belly state (at least 1 hour before meal), and can quickly reach the maximal blood concentration (within about 30 minutes) and control gastric acid very effectively.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a pharmaceutical composition containing esomeprazole. Background technique [0002] Esomeprazole Magnesium (Esomeprazole Magnesium) chemical name: 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzene Imidazol-1-yl magnesium, esomeprazole is the S-isomer of omeprazole, which reduces gastric acid secretion through a specific targeting mechanism and is a specific inhibitor of proton pumps in parietal cells. The site and mechanism of action are: esomeprazole is a weak base, which is concentrated and converted into an active form in the high-acid environment of acid-secreting microtubules in parietal cells, thereby inhibiting the H+ / K+-ATPase (proton pump) at this site ), inhibit both basal and stimulated gastric acid secretion. [0003] Esomeprazole magnesium is suitable for the treatment of gastroesophageal reflux disease (GERD) - erosive reflux esophagitis - ...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61K47/04A61K47/12A61P1/04
Inventor 关文捷梁仁兴陈果王晓玲郭瑞唐雪枫
Owner CHENGDU XINJIE HIGH TECH DEV CO LTD
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